Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tryptophan Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.65 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.58 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.58 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.58 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.58 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.58 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.58 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.58 |
| ▸ | HTR1E known ✓ | P28566 | 1/20 | 0.58 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.58 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.58 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.58 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.58 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.58 |
| ▸ | HCRTR1 known ✓ | O43613 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan Methyl Ester SCHEMBL29398306 | 1.00 | MEN1 (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL378072 | 1.00 | MEN1 (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL475266 | 1.00 | MEN1 (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL29401004 | 1.00 | MEN1 (0.68) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL31291573 | 0.99 | MEN1 (0.67) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL1195735 | 0.99 | MEN1 (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL19161138 | 0.99 | MEN1 (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL475267 | 0.99 | MEN1 (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL122907 | 0.99 | MEN1 (0.70) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan Methyl Ester SCHEMBL30180690 | 0.99 | MEN1 (0.70) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874660-A | Amino acid derivative-rhodamine B conjugate, preparation method thereof and application thereof as fluorescent tracer | 内蒙古农业大学 | 2025-04-25 | — | — | CN | claimed |
| CN-119776848-A | Green corrosion inhibitor and preparation method and application thereof | 三峡金沙江云川水电开发有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119409588-A | Caffeoyl amino acid methyl ester derivative and preparation method and application thereof | 西北大学 | 2025-02-11 | — | — | CN | claimed |
| CN-119080775-A | Preparation method of tadalafil | 威胜生物医药(苏州)股份有限公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118666841-A | Indole-tetramic acid compound, preparation and medical application thereof | 中国医学科学院药物研究所 | 2024-09-20 | — | — | CN | claimed |
| CN-117886816-A | Beta-carboline chalcone compound and preparation method and application thereof | 五邑大学 | 2024-04-16 | — | — | CN | claimed |
| CN-117801004-A | Method for alkynyl at four-position of indole carbon based on C-H bond activation | 上海交通大学 | 2024-04-02 | — | — | CN | claimed |
| CN-113912524-B | Polypeptide compound containing sulfur amide and synthesis method thereof | 华东师范大学 | 2023-12-01 | — | — | CN | claimed |
| CN-113527399-B | Ginsenoside CK derivative and application thereof in preparation of antitumor drugs | 陕西巨子生物技术有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-114671955-A | Cell activation energy protein and preparation method thereof | 上海艾苛密进出口有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-104274412-A | Pharmaceutical preparation containing temozolomide, pharmaceutically acceptable salts or other derivatives thereof | BEIJING HENGRUI KANGDA PHARMACEUTICAL SCI & TECH DEV CO LTD | 2015-01-14 | — | — | CN | claimed |
| CN-103467359-A | Cinnamon amides histone deacetylase inhibitor with benzpyrole and preparation method and application of same | UNIV SHANDONG | 2013-12-25 | — | — | CN | claimed |
| CN-102671637-B | Biomimetic specific immune adsorption material with PAMAM (Polyamidoamine) as spacer arm, and preparation method and application thereof | UNIV SOUTH CHINA TECH | 2013-10-30 | — | — | CN | claimed |
| CN-103159827-A | Synthesis, anti-thrombotic activity, and application of (1R, 3S) -1-p-nitrophenyl-1,2,3,4-tetrahydro-beta-carboline acyl amino acid | UNIV CAPITAL MEDICAL | 2013-06-19 | — | — | CN | claimed |
| CN-103159758-A | (1S,3S)-1-p-nitrophenyl-1,2,3,4-tetrahydro-beta-carboline acyl amino acid, and synthesis, antithrombotic activity and application as antithrombotic agent thereof | UNIV CAPITAL MEDICAL | 2013-06-19 | — | — | CN | claimed |
| CN-101654426-B | Method for preparing ilomastat | INST PHARM & TOXICOLOGY AMMS | 2013-04-17 | — | — | CN | claimed |
| CN-102746213-A | Cinnamamide histone deacetylase inhibitor, preparation method thereof, and application thereof | WEIFANG BOCHUANG INTERNAT BIOLOG MEDICAL RES INST | 2012-10-24 | — | — | CN | claimed |
| CN-102671637-A | Biomimetic specific immune adsorption material with PAMAM (Polyamidoamine) as spacer arm, and preparation method and application thereof | UNIV SOUTH CHINA TECH | 2012-09-19 | — | — | CN | claimed |
| CN-101654426-A | Method for preparing ilomastat | POISON MED INST PLA MED ACAD | 2010-02-24 | — | — | CN | claimed |
| WO-2007052283-A1 | AN IMPROVED PROCESS FOR PREPARING TADALAFIL AND ITS INTERMEDIATE | ALEMBIC LIMITED (IN) | 2007-05-10 | — | — | WO | claimed |