Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.60 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.60 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.60 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.60 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.60 |
| ▸ | HTR1E known ✓ | P28566 | 1/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.60 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.60 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.60 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.60 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.60 |
| ▸ | SCN9A known ✓ | Q15858 | 2/20 | 0.59 |
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.57 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.53 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL901447 | 1.00 | KDM4E (0.76) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL8403649 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL29865910 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL358778 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL29400974 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL29382126 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL2726806 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL617181 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL8403647 | 0.98 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| Acetic Acid SCHEMBL25253475 | 0.93 | KDM4E (0.74) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119112883-A | Use of L-tryptophanamide hydrochloride and antimicrobial compositions | 华南农业大学 | 2024-12-13 | — | — | CN | disclosed |
| EP-2260022-B1 | SUBSTITUTED CYCLOHEXYLDIAMINES | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| WO-2014154871-A1 | DYEING PROCESS USING AN IRIDOID COMPOUND AND DEVICES FOR THE SAME | L'OREAL (FR) | 2014-10-02 | — | — | WO | disclosed |
| WO-2013045702-A2 | DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A SPECIFIC NUCLEOPHILE OR AN AMINO OR THIO POLYMER, DYEING PROCESS, AND DEVICE THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045704-A2 | DYE COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICES THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045701-A2 | DYEING PROCESS USING A COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A NUCLEOPHILE OR AN AMINO OR THIO POLYMER, COMPOSITION AND DEVICES THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045703-A1 | DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| US-8357705-B2 | Substituted cyclohexyldiamines | GRUENENTHAL GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| CN-102046596-A | Substituted cyclohexanediamines | GRUENENTHAL GMBH | 2011-05-04 | — | — | CN | disclosed |
| EP-2260022-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | Grünenthal GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| US-6030983-A | ANTITUMOR AND -CARCINOGENIC AGENTS; ANTIBIOTICS; BACTERICIDES; VIRICIDES; PARACITICIDES; ENZYME INHIBITORS; POLYMERASES; FARNESYL-PROTEIN TRANSFERASE; RAS PROTEINS | BALL STATE UNIVERSITY (US) | 2000-02-29 | — | — | US | disclosed |
| US-5712289-A | ANTITUMOR AGENTS, INTERMEDIATES FOR LAVENDAMYCINS | BALL STATE UNIVERSITY (US) | 1998-01-27 | — | — | US | disclosed |
| CN-1155883-A | Substituted alkyldiamine derivatives and their use as tachykinin antagonists | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | CN | disclosed |
| US-5646150-A | ADMINISTERING AS ANTITUMOR AGENT, ANTIPROTOZOA AGENT, VIRICIDE, PARASITICIDE, OR BACTERICIDE | BALL STATE UNIVERSITY (US) | 1997-07-08 | — | — | US | disclosed |
| US-5525611-A | ANTITUMOR AGENT, BACTERICIDES, VIRICIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1996-06-11 | — | — | US | disclosed |
| US-5166136-A | SPIROLACTAM CONTAINING PEPTIDES | GLAXO GROUP LIMITED (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0449884-A4 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0449884-A1 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | ABBOTT LABORATORIES (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990006937-A1 | DERIVATIVES OF TETRAPEPTIDES AS CCK AGONISTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |
| EP-0360390-A1 | Spirolactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-03-28 | — | — | EP | disclosed |