Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 7/20 | 0.75 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.58 |
| ▸ | HSP90AB1 known ✓ | P08238 | 1/20 | 0.58 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | MPO | P05164 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.58 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.58 |
| ▸ | NMBR | P28336 | 2/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28897384 | 1.00 | TACR1 (0.75) | TACR1MAPTMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL29401056 | 1.00 | TACR1 (0.75) | TACR1MAPTMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL29401116 | 1.00 | TACR1 (0.75) | TACR1MAPTMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL4685036 | 1.00 | TACR1 (0.75) | TACR1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL1167913 | 0.99 | TACR1 (0.77) | TACR1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8025702 | 0.99 | TACR1 (0.77) | TACR1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL1167914 | 0.99 | TACR1 (0.77) | TACR1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL31119836 | 0.99 | TACR1 (0.77) | TACR1MAPTMEN1KMT2AKDM4E | |
| Phosphoric Acid SCHEMBL27857626 | 0.94 | TACR1 (0.71) | TACR1MAPTMEN1KMT2AKDM4E | |
| Trifluoroacetic Acid SCHEMBL8787543 | 0.92 | TACR1 (0.68) | TACR1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574710-B | Dendritic tryptophan compound, preparation method thereof and application thereof as antibacterial agent | 威海晨源分子新材料有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-111518275-B | Dendritic tryptophan compound, preparation method thereof and application thereof as virus invasion inhibitor | 威海晨源分子新材料有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-111574710-A | Dendritic tryptophan compound, preparation method thereof and application thereof as antibacterial agent | 威海晨源分子新材料有限公司 | 2020-08-25 | — | — | CN | claimed |
| CN-111518275-A | Dendritic tryptophan compound, preparation method thereof and application thereof as virus invasion inhibitor | 威海晨源分子新材料有限公司 | 2020-08-11 | — | — | CN | claimed |
| JP-11228573-A | — | — | None | — | — | JP | disclosed |
| JP-4327592-A | — | — | None | — | — | JP | disclosed |
| CN-115477656-B | Dioxahexacyclic-tetrahydrocarboline-3-formylamino acid targeting P-selectin, preparation and application | 首都医科大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-114644583-B | Indole derivative and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-02-06 | — | — | CN | disclosed |
| CN-115477656-A | Dioxane-tetrahydro carboline-3-formylamino acid with P-selectin as target and preparation and application thereof | 首都医科大学 | 2022-12-16 | — | — | CN | disclosed |
| CN-111574710-B | Dendritic tryptophan compound, preparation method thereof and application thereof as antibacterial agent | 威海晨源分子新材料有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-111518275-B | Dendritic tryptophan compound, preparation method thereof and application thereof as virus invasion inhibitor | 威海晨源分子新材料有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-114644583-A | Indole derivative and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-06-21 | — | — | CN | disclosed |
| JP-H04327592-A | PHOSPHONIC ACID AMIDE DERIVATIVE | NIPPON CHEMIPHAR CO LTD | 1992-11-17 | — | — | JP | disclosed |
| WO-1992013545-A1 | ENDOTHELIN CONVERTING ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1992-08-20 | — | — | WO | disclosed |
| WO-1991012267-A1 | ANTI-OXIDATIVE AND ANTI-INFLAMMATORY METAL:PEPTIDE COMPLEXES AND USES THEREOF | PROCYTE CORPORATION (US) | 1991-08-22 | — | — | WO | disclosed |
| US-4978669-A | ALTERING MACRONUTRIENT PREFERENCE | NEUREX CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| WO-1990014827-A1 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO-β-CARBOLINE DERIVATIVES | NEUREX CORPORATION (US) | 1990-12-13 | — | — | WO | disclosed |
| EP-0190588-A1 | Quinazolino-1,4-benzodiazepin-6,9-diones, processes for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | disclosed |
| US-4554272-A | CHOLECYSTOKININ INHIBITORS | MERCK & CO., INC. (US) | 1985-11-19 | — | — | US | disclosed |
| US-3953416-A | Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same | FOLKERS KARL | 1976-04-27 | — | — | US | disclosed |