Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenetole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 known ✓ | P22001 | 1/20 | 0.55 |
| ▸ | CHRNB4 known ✓ | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 known ✓ | P32297 | 2/20 | 0.50 |
| ▸ | CHRNA7 known ✓ | P36544 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 4/20 | 0.77 |
| ▸ | NQO1 | P15559 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenetole SCHEMBL14953870 | 0.97 | LTA4H (0.74) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL14953956 | 0.97 | LTA4H (0.74) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL499918 | 0.97 | LTA4H (0.81) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL18492 | 0.97 | — | — | |
| Phenetole SCHEMBL10779391 | 0.97 | LTA4H (0.81) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL11651346 | 0.95 | LTA4H (0.71) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL28200795 | 0.95 | LTA4H (0.71) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL11659651 | 0.95 | LTA4H (0.71) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL11569608 | 0.94 | LTA4H (0.77) | LTA4HNQO1RELAKCNA3TSHR | |
| Phenetole SCHEMBL14954246 | 0.94 | LTA4H (0.77) | LTA4HNQO1RELAKCNA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105695322-B | Style refuse fermenter and its fermentation process that a kind of aerobic-anaerobic is combined | 徐州工程学院 | 2017-10-13 | — | — | CN | claimed |
| CN-105695322-B | Style refuse fermenter and its fermentation process that a kind of aerobic-anaerobic is combined | 徐州工程学院 | 2017-10-13 | — | — | CN | disclosed |
| WO-2009078029-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF TRANS 3,4- DIARYLCHROMAN AND THEIR DERIVATIVES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-06-25 | — | — | WO | disclosed |
| EP-2061421-A2 | POLYMER THICKENED HAIR COLOURING AND BLEACHING COMPOSITIONS | The Procter and Gamble Company (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008015646-A2 | POLYMER THICKENED HAIR COLOURING AND BLEACHING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-07 | — | — | WO | disclosed |
| EP-1879541-A1 | COMPOSITIONS COMPRISING DISCRETE PARTICLE AGGREGATES AND/OR AGGLOMERATE FOR APPLICATION TO KERATIN FIBERS | The Procter and Gamble Company (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006118940-A1 | COMPOSITIONS COMPRISING DISCRETE PARTICLE AGGREGATES AND/OR AGGLOMERATE FOR APPLICATION TO KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006118879-A1 | MICELLE THICKENING SYSTEMS FOR HAIR COLOURANT AND BLEACHING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006060567-A2 | HAIR COLOURING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006060569-A2 | POLYMER THICKENED HAIR COLOURING AND BLEACHING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006060565-A2 | HIGH LEVEL CARBONATE AND/OR OXIDANT HAIR COLOURING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006060568-A1 | THICKENED HAIR COLOURANT AND BLEACHING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2006-06-08 | — | — | WO | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |