Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 known ✓ | P03952 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 14/20 | 0.56 |
| ▸ | F10 | P00742 | 12/20 | 0.56 |
| ▸ | PLG | P00747 | 12/20 | 0.56 |
| ▸ | PLAU | P00749 | 12/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.56 |
| ▸ | PLAT | P00750 | 9/20 | 0.56 |
| ▸ | HPN | P05981 | 3/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.56 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29614824 | 0.99 | F2 (0.58) | F2F10PLGPLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL688900 | 0.99 | F2 (0.58) | F2F10PLGPLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL1256806 | 0.99 | F2 (0.58) | F2F10PLGPLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL29692564 | 0.99 | F2 (0.58) | F2F10PLGPLAUPRSS1 | |
| SCHEMBL419839 | 0.97 | F2 (0.59) | F2F10PLGPLAUPRSS1 | |
| SCHEMBL29429330 | 0.97 | F2 (0.59) | F2F10PLGPLAUPRSS1 | |
| SCHEMBL2874094 | 0.81 | F2 (0.59) | F2F10PLGPLAUPRSS1 | |
| SCHEMBL29493199 | 0.77 | F2 (0.70) | F2F10PLGPLAUPRSS1 | |
| SCHEMBL2864097 | 0.75 | PLAU (0.52) | F2F10PLGPLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL6785673 | 0.74 | F2 (0.62) | F2F10PLGPLAUPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034093-B1 | COMPOSITIONS AND METHODS OF TREATING TUMORS | UNIV PENNSYLVANIA (US) | 2019-03-13 | — | — | EP | disclosed |
| US-10227658-B2 | Methods for the analysis of spitz tumor samples | ABBOTT MOLECULAR INC. (US) | 2019-03-12 | — | — | US | disclosed |
| EP-3272882-B1 | MATERIALS AND METHODS FOR PROGNOSIS OF PROGRESSION OF BARRETT'S ESOPHAGUS | ACAD MEDISCH CT (NL) | 2019-02-20 | — | — | EP | disclosed |
| EP-2798080-B1 | MATERIALS AND METHODS FOR DIAGNOSIS, AND PROGNOSIS OF PANCREATOBILIARY CANCER | ABBOTT MOLECULAR INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3399053-A1 | CELL PREPARATIONS AND CELL SUPPORTS AND THEIR USE IN THERANOSIS | Abbott Molecular Inc. (US) | 2018-11-07 | — | — | EP | disclosed |
| US-20180291465-A1 | MATERIALS AND METHODS FOR ASSESSMENT OF COLORECTAL ADENOMA | ABBOTT MOLECULAR INC (US) | 2018-10-11 | — | — | US | disclosed |
| US-9994908-B2 | Materials and methods for assessment of colorectal adenoma | ABBOTT MOLECULAR INC. (US) | 2018-06-12 | — | — | US | disclosed |
| EP-3272882-A1 | MATERIALS AND METHODS FOR PROGNOSIS OF PROGRESSION OF BARRETT'S ESOPHAGUS | Academisch Medisch Centrum (NL) | 2018-01-24 | — | — | EP | disclosed |
| EP-2758544-B1 | MATERIALS AND METHODS FOR PROGNOSIS OF PROGRESSION OF BARRETT'S ESOPHAGUS | ACAD MEDISCH CT (NL) | 2017-10-18 | — | — | EP | disclosed |
| EP-3211099-A1 | MATERIALS AND METHODS FOR DIAGNOSIS OF MALIGNANT MELANOMA AND PROGNOSIS OF METASTASIS OF MALIGNANT MELANOMA | Abbott Molecular Inc. (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20130149704-A1 | MATERIALS AND METHODS FOR DIAGNOSIS OF MALIGNANT MELANOMA AND PROGNOSIS OF METASTASIS OF MALIGNANT MELANOMA | ABBOTT MOLECULAR INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20130078632-A1 | MATERIALS AND METHODS FOR PROGNOSIS OF PROGRESSION OF BARRETT'S ESOPHAGUS | ACADEMISCH MEDISCH CENTRUM (NL) | 2013-03-28 | — | — | US | disclosed |
| WO-2013041684-A1 | MATERIALS AND METHODS FOR PROGNOSIS OF PROGRESSION OF BARRETT'S ESOPHAGUS | ACADEMISCH MEDISCH CENTRUM (NL) | 2013-03-28 | — | — | WO | disclosed |
| US-7625558-B2 | Anticancer agents; administering nucleic acid which dimerizes with protein | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-12-01 | — | — | US | disclosed |
| US-20090010935-A1 | Compositions and Methods of Treating Tumors | NIH - DEITR | 2009-01-08 | — | — | US | disclosed |
| EP-1745799-A2 | Compositions and methods of treating tumors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1058562-B1 | COMPOSITIONS AND METHODS OF TREATING TUMORS | UNIV PENNSYLVANIA (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1058562-A4 | COMPOSITIONS AND METHODS OF TREATING TUMORS | UNIV PENNSYLVANIA (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-1058562-A1 | COMPOSITIONS AND METHODS OF TREATING TUMORS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999044645-A1 | COMPOSITIONS AND METHODS OF TREATING TUMORS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-09-10 | — | — | WO | disclosed |