Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Norspermidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.86 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.67 |
| ▸ | UBE2N | P61088 | 1/20 | 0.93 |
| ▸ | MAPT | P10636 | 1/20 | 0.93 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.93 |
| ▸ | LMNA | P02545 | 3/20 | 0.87 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.87 |
| ▸ | CA12 | O43570 | 5/20 | 0.86 |
| ▸ | CA6 | P23280 | 5/20 | 0.86 |
| ▸ | CA7 | P43166 | 5/20 | 0.86 |
| ▸ | CA9 | Q16790 | 5/20 | 0.86 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.86 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.86 |
| ▸ | CA4 | P22748 | 4/20 | 0.86 |
| ▸ | CA5A | P35218 | 4/20 | 0.86 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.86 |
| ▸ | CASP2 | P42575 | 2/20 | 0.86 |
| ▸ | F13A1 | P00488 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | THPO | P40225 | 2/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norspermidine SCHEMBL10444207 | 1.00 | UBE2N (0.93) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Thermine SCHEMBL30083114 | 0.96 | UBE2N (0.87) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8977288 | 0.96 | CASP2 (0.93) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Spermine SCHEMBL15300022 | 0.96 | UBE2N (1.00) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Spermine SCHEMBL7709508 | 0.96 | UBE2N (1.00) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Spermine SCHEMBL348192 | 0.96 | UBE2N (1.00) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Spermine SCHEMBL1167355 | 0.96 | UBE2N (1.00) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Spermine SCHEMBL348194 | 0.96 | UBE2N (1.00) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Norspermidine SCHEMBL22129782 | 0.96 | CA12 (0.92) | UBE2NMAPTPMP22LMNASMN1; SMN2 | |
| Norspermidine SCHEMBL15387 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4155855-A | INCLUDING FABRIC SUBSTANTIVE AGENT; STORAGE STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1979-05-22 | — | — | US | claimed |
| EP-0000406-A1 | Concentrated liquid fabric softener containing mixed active system | Procter & Gamble European Technical Center (BE) | 1979-01-24 | — | — | EP | claimed |
| EP-1922397-B1 | FABRIC CONDITIONING COMPOSITION | UNILEVER PLC (GB) | 2013-12-25 | — | — | EP | disclosed |
| US-20090036346-A1 | Fabric Conditioning Composition | Henkel IP & Holding GmbH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-20050075266-A1 | Polymers and process for controlling rheology of aqueous compositions | CHANG CHING-JEN (US) | 2005-04-07 | — | — | US | disclosed |
| EP-1520909-A1 | Polymers and process for controlling rheology of aqueous compositions | Rohm and Haas Company (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1175484-B1 | LAUNDRY COMPOSITIONS | UNILEVER NV (NL) | 2004-06-30 | — | — | EP | disclosed |
| EP-1175484-A1 | LAUNDRY COMPOSITIONS | UNILEVER N.V. (NL) | 2002-01-30 | — | — | EP | disclosed |
| EP-0695166-B1 | PERFUME COMPOSITION | QUEST INTERNAT NEDERLAND BV (NL) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000068352-A1 | LAUNDRY COMPOSITIONS | UNILEVER N.V. (NL) | 2000-11-16 | — | — | WO | disclosed |
| EP-0695166-A1 | PERFUME COMPOSITION | QUEST INTERNATIONAL NEDERLAND BV (NL) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024999-A2 | PERFUME COMPOSITION | QUEST INTERNATIONAL B.V. (NL) | 1994-11-10 | — | — | WO | disclosed |
| EP-0018039-B2 | FABRIC SOFTENING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 1988-08-24 | — | — | EP | disclosed |
| EP-0043622-B1 | FABRIC SOFTENING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 1984-11-21 | — | — | EP | disclosed |
| EP-0018039-B1 | FABRIC SOFTENING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4386000-A | IMPROVED VISCOSITY AND STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1983-05-31 | — | — | US | disclosed |
| EP-0043622-A1 | Fabric softening composition | THE PROCTER & GAMBLE COMPANY (US) | 1982-01-13 | — | — | EP | disclosed |
| US-4155855-A | INCLUDING FABRIC SUBSTANTIVE AGENT; STORAGE STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4149978-A | CATIONIC FABRIC SOFTENER AND A HYDROCARBON | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-17 | — | — | US | disclosed |
| EP-0000406-A1 | Concentrated liquid fabric softener containing mixed active system | Procter & Gamble European Technical Center (BE) | 1979-01-24 | — | — | EP | disclosed |