SCHEMBL4411275

SCHEMBL4411275

COC(C(=O)c1ccccc1)C(=O)c1ccc(C(C)(C)C)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TNF P01375 1/20 0.50
KLF5 Q13887 1/20 0.50
NOD1 Q9Y239 1/20 0.50
KCNK9 Q9NPC2 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
SRD5A2 P31213 1/20 0.47
RAB9A P51151 4/20 0.46
LMNA P02545 2/20 0.46
NPC1 O15118 3/20 0.44
HDAC1 Q13547 1/20 0.44
POLB P06746 1/20 0.44
CASP3 P42574 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
ALDH1A1 P00352 4/20 0.44
RECQL P46063 2/20 0.44
ESRRG P62508 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL146504 0.86 TSHR (0.52) MAPTTDP1L3MBTL1MEN1KMT2A
Avobenzone SCHEMBL19717690 0.85 ALDH1A1 (0.71) MAPTTDP1L3MBTL1MEN1KMT2A
SCHEMBL7930303 0.81 KMT2A (0.55) MAPTTDP1L3MBTL1TNFKLF5
SCHEMBL7162385 0.80 MAPT (0.60) MAPTTDP1L3MBTL1KCNK9MEN1
SCHEMBL28567268 0.79 MAPT (0.50) MAPTTDP1L3MBTL1MEN1KMT2A
SCHEMBL27285922 0.78 TSHR (0.48) MAPTTDP1L3MBTL1MEN1KMT2A
SCHEMBL4907654 0.78 PLK1 (0.49) L3MBTL1MEN1KMT2ARAB9ALMNA
SCHEMBL28783553 0.77 ALDH1A1 (0.49) MAPTTDP1L3MBTL1MEN1KMT2A
SCHEMBL8665164 0.77 ALDH1A1 (0.49) MAPTTDP1L3MBTL1MEN1KMT2A
SCHEMBL14947050 0.76 CES2 (0.65) MAPTTDP1L3MBTL1TNFKLF5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3315138-B1 STICK-SHAPED SUBSTRATE CONTAINING LIPID-PEPTIDE-TYPE COMPOUND NISSAN CHEMICAL CORP (JP) 2020-05-27 EP disclosed
EP-3311797-B1 STICK-SHAPED SUBSTRATE CONTAINING LIPID-PEPTIDE-TYPE COMPOUND NISSAN CHEMICAL CORP (JP) 2020-02-26 EP disclosed
EP-3185850-B1 SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR SHOWA DENKO KK (JP) 2019-10-09 EP disclosed
EP-3536308-A1 SKIN CARE PREPARATIONS Nisshinbo Holdings Inc. (JP) 2019-09-11 EP disclosed
US-20190254938-A1 SKIN COSMETICS NISSHINBO HOLDINGS INC. (JP) 2019-08-22 US disclosed
US-20180200173-A1 STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-07-19 US disclosed
US-20180169243-A1 STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-06-21 US disclosed
EP-3315138-A1 STICK-SHAPED SUBSTRATE CONTAINING LIPID-PEPTIDE-TYPE COMPOUND Nissan Chemical Industries, Ltd. (JP) 2018-05-02 EP disclosed
EP-3311797-A1 STICK-SHAPED SUBSTRATE CONTAINING LIPID-PEPTIDE-TYPE COMPOUND Nissan Chemical Industries, Ltd. (JP) 2018-04-25 EP disclosed
US-20170312207-A1 MOISTURIZING AGENT SHOWA DENKO K.K. (JP) 2017-11-02 US disclosed
EP-3213753-A1 SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION Showa Denko K.K. (JP) 2017-09-06 EP disclosed
EP-3185850-A1 SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR Showa Denko K.K. (JP) 2017-07-05 EP disclosed
US-20170143608-A1 SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR SHOWA DENKO K.K. (JP) 2017-05-25 US disclosed
WO-2016031634-A1 SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR SHOWA DENKO K. K. (JP) 2016-03-03 WO disclosed
US-20090053155-A1 Cosmetic Compositions Containing Silicone/Organic Copolymer REVLON CONSUMER PRODUCTS CORPORATION (US) 2009-02-26 US disclosed
US-20080152606-A1 Compositions for Treating Keratinous Surfaces REVLON CONSUMER PRODUCTS CORPORATION (US) 2008-06-26 US disclosed
US-20070071700-A1 Cosmetic compositions containing silicone/organic copolymers CITICORP USA, INC. 2007-03-29 US disclosed
US-20070041922-A1 Compositions for Treating Keratinous Surfaces CITICORP USA, INC. 2007-02-22 US disclosed
US-20070020216-A1 Compositions for Treating Keratinous Surfaces REVLON CONSUMER PRODUCTS CORPORATION 2007-01-25 US disclosed
US-20050118124-A1 A foundation makeup, concealer, powder, eyeshadow, mascara, eyeliner, or blush with Acetyl Hexapeptide-3 as a primary ingredient; improved aging and wrinkle resistances CITICORP USA, INC. 2005-06-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070020216-A1 Compositions for Treating Keratinous Surfaces KRT18, FN1, HKDC1 MAPT 1288/4885TDP1 957/4885L3MBTL1 874/4885
US-20170143608-A1 SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR RBP4, RBP1, RARA MAPT 4130/4885TDP1 1959/4885L3MBTL1 2523/4885
US-20070071700-A1 Cosmetic compositions containing silicone/organic copolymers CUTA, LAGE3, SMURF1 MAPT 961/4885TDP1 577/4885L3MBTL1 1817/4885
US-20050118124-A1 A foundation makeup, concealer, powder, eyeshadow, mascara, eyeliner, or blush with Acetyl Hexapeptide-3 as a primary ingredient; improved aging and wrinkle resistances IGFBP3, MC3R, MC1R MAPT 2384/4885TDP1 4024/4885L3MBTL1 1196/4885
US-20070041922-A1 Compositions for Treating Keratinous Surfaces CUTA, KRT18, MCOLN2 MAPT 215/4885TDP1 2405/4885L3MBTL1 1528/4885
US-20080152606-A1 Compositions for Treating Keratinous Surfaces KRT18, PLOD3, GLA MAPT 1670/4885TDP1 3033/4885L3MBTL1 2223/4885
US-20180200173-A1 STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND CUTA, BDKRB2, C9 MAPT 3956/4885TDP1 3785/4885L3MBTL1 514/4885
US-20090053155-A1 Cosmetic Compositions Containing Silicone/Organic Copolymer LAGE3, CUTA, SMURF1 MAPT 928/4885TDP1 601/4885L3MBTL1 2159/4885
US-20180169243-A1 STICK-SHAPED BASE MATERIAL COMPRISING LIPID PEPTIDE COMPOUND CUTA, CFH, C9 MAPT 2720/4885TDP1 4156/4885L3MBTL1 282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.