Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A known ✓ | P35499 | 2/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.41 |
| ▸ | TACR1 known ✓ | P25103 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.40 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138049 | 0.98 | EPHX1 (0.47) | EPHX1SCN4AANPEPSIGMAR1TACR1 | |
| SCHEMBL614446 | 0.80 | EPHX1 (0.53) | EPHX1SCN4AANPEPSIGMAR1TACR1 | |
| Benzylamine SCHEMBL8464424 | 0.79 | LOXL2 (0.52) | SIGMAR1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL5567986 | 0.79 | EPHX1 (0.73) | EPHX1SCN4AANPEPSIGMAR1SLC6A2 | |
| Hydrochloric Acid SCHEMBL18547947 | 0.79 | EPHX1 (0.73) | EPHX1SCN4AANPEPSIGMAR1SLC6A2 | |
| Benzylamine SCHEMBL18151475 | 0.78 | LOXL2 (0.50) | SIGMAR1SLC6A2TAAR1MAOASLC6A4 | |
| Hydrochloric Acid SCHEMBL20896980 | 0.78 | EPHX1 (0.47) | EPHX1SCN4AANPEPSIGMAR1TACR1 | |
| SCHEMBL137074 | 0.77 | EPHX1 (0.76) | EPHX1SCN4AANPEPSIGMAR1SLC6A2 | |
| SCHEMBL3441656 | 0.77 | EPHX1 (0.76) | EPHX1SCN4AANPEPSIGMAR1SLC6A2 | |
| SCHEMBL243771 | 0.77 | EPHX1 (0.76) | EPHX1SCN4AANPEPSIGMAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853546-B1 | Modified starch compositions, starch composite foam materials and method for preparing the starch composite foam material | IND TECH RES INST (TW) | 2016-05-25 | — | — | EP | claimed |
| EP-2853546-A1 | Modified starch compositions, starch composite foam materials and method for preparing the starch composite foam material | Industrial Technology Research Institute (TW) | 2015-04-01 | — | — | EP | claimed |
| US-20150065591-A1 | MODIFIED STARCH COMPOSITIONS, STARCH COMPOSITE FOAM MATERIALS AND METHOD FOR PREPARING THE STARCH COMPOSITE FOAM MATERIAL | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2015-03-05 | — | — | US | claimed |
| EP-1945750-A2 | MICROARRAY HAVING A BASE CLEAVABLE SUCINATE LINKER | Combimatrix Corporation (US) | 2008-07-23 | — | — | EP | claimed |
| US-20080125327-A1 | Bonding amino moieties to solid surface with reactive hydroxyl groups, bonding succinate moieties to the amine groups through amide bonds to form cleavable linkers attached to the solid surface, bonding a succinate group, a sugar group and a base group, synthesizing oligonucleotides | CUSTOMARRAY, INC. | 2008-05-29 | — | — | US | claimed |
| WO-2007035500-A2 | MICROARRAY HAVING A BASE CLEAVABLE SUCCINATE LINKER | COMBIMATRIX CORPORATION (US) | 2007-03-29 | — | — | WO | claimed |
| US-20070065877-A1 | Microarray having a base cleavable succinate linker | COMBIMATRIX CORPORATION | 2007-03-22 | — | — | US | claimed |
| US-10428265-B2 | Selective acidizing of a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190227060-A1 | MICROARRAY HAVING A BASE CLEAVABLE LINKER | CUSTOMARRAY, INC. (US) | 2019-07-25 | — | — | US | disclosed |
| US-10261075-B2 | Microarray having a base cleavable linker | CUSTOMARRAY, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180267032-A1 | Microarray Having a Base Cleavable Linker | CUSTOMARRAY, INC. (US) | 2018-09-20 | — | — | US | disclosed |
| US-9983204-B2 | Microarray having a base cleavable linker | CUSTOMARRAY, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9850362-B2 | Modified starch compositions, starch composite foam materials and method for preparing the starch composite foam material | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2017-12-26 | — | — | US | disclosed |
| US-7461697-B2 | Methods of modifying particulate surfaces to affect acidic sites thereon | HALLIBURTON ENERGY SERVICES, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| EP-1945750-A2 | MICROARRAY HAVING A BASE CLEAVABLE SUCINATE LINKER | Combimatrix Corporation (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20080125327-A1 | Bonding amino moieties to solid surface with reactive hydroxyl groups, bonding succinate moieties to the amine groups through amide bonds to form cleavable linkers attached to the solid surface, bonding a succinate group, a sugar group and a base group, synthesizing oligonucleotides | CUSTOMARRAY, INC. | 2008-05-29 | — | — | US | disclosed |
| US-20070114030-A1 | Methods of modifying particulate surfaces to affect acidic sites thereon | HALLIBURTON ENERGY SERVICES, INC. | 2007-05-24 | — | — | US | disclosed |
| WO-2007057700-A1 | METHODS OF MODIFYING PARTICULATE SURFACES TO AFFECT ACIDIC SITES THEREON | HALLIBURTON ENERGY SERVICE, INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007035500-A2 | MICROARRAY HAVING A BASE CLEAVABLE SUCCINATE LINKER | COMBIMATRIX CORPORATION (US) | 2007-03-29 | — | — | WO | disclosed |
| US-20070065877-A1 | Microarray having a base cleavable succinate linker | COMBIMATRIX CORPORATION | 2007-03-22 | — | — | US | disclosed |