Barbituric Acid

Barbituric Acid

SCHEMBL4663533

Cl.O=C1CC(=O)NC(=O)N1.[NaH]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Barbituric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN known ✓ Q96SW2 4/20 0.39
ITGB3 known ✓ P05106 1/20 0.35
SRC known ✓ P12931 1/20 0.30
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
HPGD P15428 1/20 0.50
HIF1A Q16665 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KDM4E B2RXH2 1/20 0.35
OGT O15294 1/20 0.35
USP2 O75604 1/20 0.35
MAPT P10636 1/20 0.35
RECQL P46063 1/20 0.35
BLM P54132 1/20 0.35
ITGB1 P05556 1/20 0.35
ITGAV P06756 1/20 0.35
ITGA4 P13612 1/20 0.35
AHR P35869 1/20 0.33
PDK2 Q15119 1/20 0.33
TDP2 O95551 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Barbituric Acid SCHEMBL1974368 0.97 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL28610609 0.97 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL28362335 0.97 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL4560317 0.93 ALDH1A1 (0.55) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL9941322 0.93
Barbituric Acid SCHEMBL38707 0.93
Barbituric Acid SCHEMBL1972516 0.90 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL29254329 0.90 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL1973830 0.90 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10
Barbituric Acid SCHEMBL28943815 0.90 ALDH1A1 (0.52) ALDH1A1CYP1A2HPGDHIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112129934-A Ferritin detection kit and preparation method thereof 上海捷门生物技术有限公司 2020-12-25 CN claimed
CN-107167356-B Coloring agent capable of quickly developing color after cells in urine are colored and using method thereof 迪瑞医疗科技股份有限公司 2020-02-04 CN claimed
CN-114874299-A Polypeptide for generating silicon dioxide and application and composition thereof 温州大学 2022-08-09 CN disclosed
EP-1925937-A1 Method for assaying antigen related to disorders caused by mental stress Suntory Limited (JP) 2008-05-28 EP disclosed
EP-0907080-B1 METHOD FOR ASSAYING ANTIGEN RELATING TO MENTAL STRESS DISORDERS SUNTORY LTD (JP) 2008-03-12 EP disclosed
US-6265227-B1 IMMUNOASSAY DIAGNOSIS BY CONTACTING MENTAL STRESS-RELATED PROTEIN WITH ANTIBODY OR FRAGMENT, DETECTING PRESENCE OF IMMUNOCOMPLEXES, AND CORRELATING WITH CONTROL STANDARD TO CALCULATE CONCENTRATION SUNTORY LIMITED (JP) 2001-07-24 US disclosed
EP-0907080-A1 METHOD FOR ASSAYING ANTIGEN RELATING TO MENTAL STRESS DISORDERS SUNTORY LIMITED (JP) 1999-04-07 EP disclosed