Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ciaftalan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.32 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.32 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciaftalan SCHEMBL9317824 | 1.00 | MEN1 (0.44) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL18587431 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL14691323 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL31085 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL1160674 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL31084 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL14691039 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL1024190 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL23270396 | 0.96 | MEN1 (0.44) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL1023666 | 0.96 | MEN1 (0.44) | MEN1KMT2ATDP1RECQLTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727503-A2 | INCREASING ADHESION BETWEEN VITREOUS AND RETINA | The Regents of the University of California (US) | 2026-04-22 | — | — | EP | claimed |
| US-20260058190-A1 | High Voltage Battery Cell, Module or Pack Having a Rolled Structure and Production Method | HONEYCOMB BATTERY COMPANY (US) | 2026-02-26 | — | — | US | claimed |
| US-12476244-B2 | Surface-stabilized cathode active material particles, lithium secondary batteries containing same, and method of manufacturing | HONEYCOMB BATTERY COMPANY (US) | 2025-11-18 | — | — | US | claimed |
| CN-119371384-A | Catalyst, system and method for preparing succinic anhydride by oxo-oxidation of ethylene oxide | 上海交通大学 | 2025-01-28 | — | — | CN | claimed |
| US-12211998-B2 | Method and system for aromatic macrocyclic compounds (phthalocyanines) as cathode additives for inhibition of transition metal dissolution and stable solid electrolyte interphase formation | ENEVATE CORPORATION (US) | 2025-01-28 | — | — | US | claimed |
| WO-2024259148-A2 | INCREASING ADHESION BETWEEN VITREOUS AND RETINA | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-12-19 | — | — | WO | claimed |
| CN-110915049-B | Polymer layer for protecting lithium anode of lithium metal secondary battery and manufacturing method thereof | 纳米技术仪器公司 | 2024-10-25 | — | — | CN | claimed |
| US-12057548-B2 | Continuous process for producing electrochemical cells | HONEYCOMB BATTERY COMPANY (US) | 2024-08-06 | — | — | US | claimed |
| CN-110710023-B | Lithium metal secondary battery comprising anode-protecting polymer layer and method for manufacturing same | 纳米技术仪器公司 | 2023-11-03 | — | — | CN | claimed |
| CN-110612633-B | Non-combustible quasi-solid electrolyte and lithium secondary battery containing same | 纳米技术仪器公司 | 2023-09-12 | — | — | CN | claimed |
| EP-0786820-A2 | Organic thin film transistor with enhanced carrier mobility | MOTOROLA, INC. (US) | 1997-07-30 | — | — | EP | claimed |
| US-5120649-A | Contacting with photoreactive compound, light and oxygen | NEW YORK BLOOD CENTER, INC. (US) | 1992-06-09 | — | — | US | claimed |
| US-5035968-A | Electrography, sensitivity, durability | FUJI PHOTO FILM CO., LTD. (JP) | 1991-07-30 | — | — | US | claimed |
| US-4973536-A | LAMINATED STRUCTURE OF CHARGE GENERATING AND CHARGE TRANSPORTING LAYERS | FUJI PHOTO FILM CO., LTD. (JP) | 1990-11-27 | — | — | US | claimed |
| EP-0183570-B1 | OPTICAL RECORDING MEDIUM AND OPTICAL DISC | NEC CORPORATION (JP) | 1989-08-02 | — | — | EP | claimed |
| US-4814245-A | HIGH PHOTOSENSITIVITY; EXCELLENT DURABILITY; COPIERS; PRINTERS USING LASERS OR CATHODE RAY TUBES | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-21 | — | — | US | claimed |
| US-4740447-A | SUBSTRATE, TWO SPACER LAYERS HAVING DIFFERENT REFRACTIVE INDICES, RECORDING LAYER | NEC CORPORATION (JP) | 1988-04-26 | — | — | US | claimed |
| EP-0183570-A2 | Optical recording medium and optical disc | NEC CORPORATION (JP) | 1986-06-04 | — | — | EP | claimed |
| US-4535043-A | ALUMINUM CHLORIDE PHTHALOCYANINE AND A HYDRAZONE COMPOUND FOR CHARGE GENERATION AND TRANSPORT | CANON KABUSHIKI KAISHA (JP) | 1985-08-13 | — | — | US | claimed |
| US-4251607-A | HAVING A PHTHALOCYANINE OR PORPHIN FUNCTION AND AN ANODE OF A GROUP 1A METAL | NIPPON TELEGRAPH AND TELEPHONE PUBLIC CORPORATION (JP) | 1981-02-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260058190-A1 | High Voltage Battery Cell, Module or Pack Having a Rolled Structure and Production Method | ITGB1, CACNA2D1, ITGA1 | PARP1 349/4885GLA 1296/4885GAA 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.