Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307808 | 0.93 | — | — | |
| Fluoride SCHEMBL4618711 | 0.86 | — | — | |
| Iodide SCHEMBL2585 | 0.86 | — | — | |
| SCHEMBL7588846 | 0.86 | — | — | |
| Bromide SCHEMBL543270 | 0.86 | — | — | |
| Iodide SCHEMBL1592185 | 0.80 | — | — | |
| SCHEMBL11120742 | 0.77 | — | — | |
| SCHEMBL7520910 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL7153143 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL7156321 | 0.76 | CA2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 645 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377302-A1 | METHODS FOR SYNTHESIS OF RACEMIC, SCALEMIC, AND CHIRAL ALPHA-TOCOTRIENOL QUINONE | PTC Therapeutics, Inc. (US) | 2024-06-05 | — | — | EP | claimed |
| WO-2023009610-A1 | METHODS FOR SYNTHESIS OF RACEMIC, SCALEMIC, AND CHIRAL ALPHA-TOCOTRIENOL QUINONE | PTC THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | claimed |
| CN-108368121-B | Process for the preparation of imidazo [1,2-a ] pyrrolo [2,3-e ] pyrazines | 艾伯维公司（US） | 2023-01-13 | — | — | CN | claimed |
| US-20210363149-A1 | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF | ABBVIE INC (US) | 2021-11-25 | — | — | US | claimed |
| EP-3376865-B1 | 4-((6-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H | DOW AGROSCIENCES LLC (US) | 2021-04-14 | — | — | EP | claimed |
| US-20200291040-A1 | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF | ABBVIE INC (US) | 2020-09-17 | — | — | US | claimed |
| US-20190330185-A1 | 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION | DOW AGROSCIENCES LLC (IN) | 2019-10-31 | — | — | US | claimed |
| US-20190023714-A1 | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF | AbbVie Deutschland GmbH & Co. KG (DE) | 2019-01-24 | — | — | US | claimed |
| US-20180370946-A1 | 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION | DOW AGROSCIENCES LLC (US) | 2018-12-27 | — | — | US | claimed |
| US-20180354928-A1 | 4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION | DOW AGROSCIENCES LLC (US) | 2018-12-13 | — | — | US | claimed |
| EP-1394174-A1 | PROCESS FOR PRODUCING METHYLCOBALAMIN | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | claimed |
| EP-1394161-A1 | L−ASCORBIC ACID−2−O−MALEIC ACID−A−TOCOPHEROL DIESTER 1−PROPANOL ADDUCT AND PROCESS FOR PRODUCING THE SAME | Senju Pharmaceutical Co., Ltd. (JP) | 2004-03-03 | — | — | EP | claimed |
| US-6657057-B2 | Generation of methylcobalamin; obtain cyanocobalamin or hydroxycobalamin, incubate with reducing agent and water-soluble methylating agent, recover methylcobalamin | EISAI CO., LTD. (JP) | 2003-12-02 | — | — | US | claimed |
| EP-1339667-A1 | PROCESS FOR THE PREPARATION OF PROTECTED 1-(1-AMINOALKYL)-OXIRANES | Clariant Life Science Molecules (Italia) S.p.A. (IT) | 2003-09-03 | — | — | EP | claimed |
| US-20020183511-A1 | Process for production of methylcobalamin | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2002-12-05 | — | — | US | claimed |
| EP-1236737-A1 | PROCESS FOR PRODUCTION OF METHYLCOBALAMIN | Eisai Co., Ltd. (JP) | 2002-09-04 | — | — | EP | claimed |
| WO-2002040441-A1 | PROCESS FOR THE PREPARATION OF PROTECTED 1-(1-AMINOALKYL)-OXIRANES | CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. (IT) | 2002-05-23 | — | — | WO | claimed |
| US-5194636-A | Preparation of benzyl ketones and an oxirane | BAYER AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | claimed |
| EP-0117337-B1 | METHOD FOR PREPARATION OF SALTS OF N-PHOSPHONOMETHYLGLYCINE | STAUFFER CHEMICAL COMPANY (US) | 1988-09-07 | — | — | EP | claimed |
| US-4431594-A | REACTING THE GLYCINE DEPIVATIVE WITH AN ONIUM SALT IN WATER CONTAINING A TERTIARY AMINE AND PHASE TRANSFER AGENT | STAUFFER CHEMICAL COMPANY (US) | 1984-02-14 | — | — | US | claimed |