Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60469 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL13167192 | 0.73 | — | — | |
| SCHEMBL21954835 | 0.69 | SMN1; SMN2 (0.41) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18871426 | 0.69 | SMN1; SMN2 (0.46) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL21675668 | 0.61 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL581954 | 0.58 | ALDH1A1 (0.46) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18871416 | 0.58 | ALDH1A1 (0.46) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3650457 | 0.58 | — | — | |
| SCHEMBL23332523 | 0.57 | CA1 (0.36) | ALDH1A1L3MBTL1 | |
| SCHEMBL13615467 | 0.57 | MAPT (0.45) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4780319-A | DRUG DELIVERY USING POLYORTHOESTERS COATINGS | MERCK & CO., INC. (US) | 1988-10-25 | — | — | US | claimed |
| US-11357756-B2 | Anesthetic compositions and methods comprising imidazoline compounds | WARSAW ORTHOPEDIC, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-RE48948-E1 | Clonidine compounds in a biodegradable polymer | WARSAW ORTHOPEDIC, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| EP-2945568-B1 | CLONIDINE COMPOUNDS IN A BIODEGRADABLE FIBER | WARSAW ORTHOPEDIC INC (US) | 2020-08-19 | — | — | EP | disclosed |
| US-10363238-B2 | Methods and compositions to enhance bone growth comprising a statin | WARSAW ORTHOPEDIC, INC. (US) | 2019-07-30 | — | — | US | disclosed |
| EP-2276467-B1 | ALPHA AND BETA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF PAIN AND/OR INFLAMMATION | WARSAW ORTHOPEDIC INC (US) | 2018-11-07 | — | — | EP | disclosed |
| WO-2018136787-A1 | ANESTHETIC COMPOSITIONS AND METHODS COMPRISING IMIDAZOLINE COMPOUNDS | WARSAW ORTHOPEDIC, INC. (US) | 2018-07-26 | — | — | WO | disclosed |
| US-20180207133-A1 | ANESTHETIC COMPOSITIONS AND METHODS COMPRISING IMIDAZOLINE COMPOUNDS | WARSAW ORTHOPEDIC, INC. | 2018-07-26 | — | — | US | disclosed |
| US-9968572-B2 | Clonidine and GABA compounds in a biodegradable polymer carrier | WARSAW ORTHOPEDIC, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9867910-B2 | Clonidine compounds in a biodegradable fiber | WARSAW ORTHOPEDIC, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20090263448-A1 | Clonidine Formulation in a Polyorthoester Carrier | WARSAW ORTHOPEDIC, INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090263461-A1 | ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE DISC DISEASE | WARSAW ORTHOPEDIC, INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090264490-A1 | CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER | WARSAW ORTHOPEDIC, INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090263462-A1 | Methods for Treating Conditions Such as Dystonia and Post-Stroke Spasticity with Clonidine | WARSAW ORTHOPEDIC, INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-20090208554-A1 | Baclofen Formulation in a Polyorthoester Carrier | MEDTRONIC, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090202604-A1 | Benzodiazepine Formulation in a Polyorthoester Carrier | MEDTRONIC, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090202436-A1 | Bupivacaine Formulation in a Polyorthoester Carrier | MEDTRONIC, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| EP-2042538-A1 | Amphiphilic copolymers and compositions containing such polymers | Nirvana's Tree House (NL) | 2009-04-01 | — | — | EP | disclosed |
| WO-2009037313-A1 | AMPHIPHILIC COPOLYMERS AND COMPOSITIONS CONTAINING SUCH POLYMERS | NIRVANA'S TREE HOUSE B.V. (NL) | 2009-03-26 | — | — | WO | disclosed |
| US-4549010-A | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal | MERCK & CO., INC. (US) | 1985-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202436-A1 | Bupivacaine Formulation in a Polyorthoester Carrier | SBDS, SPAST, PRPH | ALDH1A1 840/4885MAPT 1659/4885L3MBTL1 571/4885 |
| US-20090208554-A1 | Baclofen Formulation in a Polyorthoester Carrier | SLC6A13, SUCNR1, GABBR2 | ALDH1A1 417/4885MAPT 1776/4885L3MBTL1 1055/4885 |
| US-20090263462-A1 | Methods for Treating Conditions Such as Dystonia and Post-Stroke Spasticity with Clonidine | GABRA5, SMN1; SMN2, MUSK | ALDH1A1 3177/4885MAPT 500/4885L3MBTL1 2250/4885 |
| US-11357756-B2 | Anesthetic compositions and methods comprising imidazoline compounds | OPRK1, ADRA2C, ADRB2 | ALDH1A1 2483/4885MAPT 1892/4885L3MBTL1 1640/4885 |
| US-20090263448-A1 | Clonidine Formulation in a Polyorthoester Carrier | SNCA, SMN1; SMN2, SPAST | ALDH1A1 1043/4885MAPT 1239/4885L3MBTL1 513/4885 |
| US-20090264490-A1 | CLONIDINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER | SMN1; SMN2, SNCA, NGF | ALDH1A1 1408/4885MAPT 617/4885L3MBTL1 861/4885 |
| US-20180207133-A1 | ANESTHETIC COMPOSITIONS AND METHODS COMPRISING IMIDAZOLINE COMPOUNDS | OPRK1, ADRA2C, ADRB2 | ALDH1A1 2483/4885MAPT 1892/4885L3MBTL1 1640/4885 |
| US-20090202604-A1 | Benzodiazepine Formulation in a Polyorthoester Carrier | GABRD, GABRA1, GABRA2 | ALDH1A1 552/4885MAPT 2053/4885L3MBTL1 1520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.