Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ly-294002. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 1/20 | 0.97 |
| ▸ | PDE5A known ✓ | O76074 | 1/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.97 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.97 |
| ▸ | PDE3B known ✓ | Q13370 | 1/20 | 0.97 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | PRKDC | P78527 | 18/20 | 0.97 |
| ▸ | BRD4 | O60885 | 2/20 | 0.97 |
| ▸ | BRD2 | P25440 | 2/20 | 0.97 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.97 |
| ▸ | PDE2A | O00408 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ly-294002 SCHEMBL29424167 | 0.99 | PRKDC (1.00) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| Ly-294002 SCHEMBL94377 | 0.99 | PRKDC (1.00) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL13496867 | 0.97 | PRKDC (0.97) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL31061056 | 0.94 | PRKDC (1.00) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL14041172 | 0.93 | PRKDC (1.00) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL5261685 | 0.89 | PRKDC (0.81) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL5260468 | 0.89 | PRKDC (0.81) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL4423159 | 0.89 | PRKDC (0.81) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL31060584 | 0.88 | PRKDC (1.00) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL13700043 | 0.88 | PRKDC (0.80) | ALDH1A1KDM4ESMN1; SMN2GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4416268-A1 | METHODS FOR PRODUCING CARTILAGE AND BONES | Murdoch Children's Research Institute (AU) | 2024-08-21 | — | — | EP | claimed |
| CN-118355110-A | Method for producing cartilage and bone | 默多克儿童研究所 | 2024-07-16 | — | — | CN | claimed |
| CN-118291390-A | Construction method of zebra fish bone loss model | 华芯微鱼(苏州)生物科技有限公司 | 2024-07-05 | — | — | CN | claimed |
| WO-2023060322-A1 | METHODS FOR PRODUCING CARTILAGE AND BONES | MURDOCH CHILDREN'S RESEARCH INSTITUTE (AU) | 2023-04-20 | — | — | WO | claimed |
| US-20140024663-A1 | ATB(0,+) AMINO ACID TRANSPORTER AS A DRUG TARGET FOR TREATMENT OF ESTROGEN RECEPTOR-POSITIVE BREAST CANCER | GEORGIA HEALTH SCIENCES UNIVERSITY RES INST INC (US) | 2014-01-23 | — | — | US | claimed |
| EP-2943564-B1 | SL327 FOR USE IN SKIN REGENERATION | INT STEM CELL CORPORATION (US) | 2026-03-25 | — | — | EP | disclosed |
| EP-4680255-A1 | METHODS FOR PRODUCING STABLE HUMAN CHONDROCTYES AND THEIR USE FOR PROMOTING CARTILLAGE GROWTH AND REPAIR | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2026-01-21 | — | — | EP | disclosed |
| EP-4677064-A1 | METHODS AND COMPOSITIONS FOR IN VITRO HAEMATOPOIESIS AND LYMPHOPOIESIS | Murdoch Children's Research Institute (AU) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024254483-A9 | GENERATING POPULATIONS OF HUMAN BLOOD AND BLOOD VESSEL PROGENITORS FROM PLURIPOTENT STEM CELLS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2025-11-06 | — | — | WO | disclosed |
| US-20250270507-A1 | METHODS FOR PRODUCING CARTILAGE AND BONES | MURDOCH CHILDREN'S RESEARCH INSTITUTE OF THE ROYAL CHILDREN'S HOSPITAL (AU) | 2025-08-28 | — | — | US | disclosed |
| US-20250154467-A1 | CREATION OF VASCULARIZED BIOLOGICAL STRUCTURES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-05-15 | — | — | US | disclosed |
| WO-2024254483-A2 | GENERATING POPULATIONS OF HUMAN BLOOD AND BLOOD VESSEL PROGENITORS FROM PLURIPOTENT STEM CELLS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2024-12-12 | — | — | WO | disclosed |
| US-20140308743-A1 | METHOD FOR CULTURING STEM CELL | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-10-16 | — | — | US | disclosed |
| EP-2774983-A1 | METHOD FOR CULTURING STEM CELL | Riken (JP) | 2014-09-10 | — | — | EP | disclosed |
| WO-2014039994-A2 | TARGETING CHEMOTHERAPY AGENT RESISTANCE IN CANCER | CORDON-CARDO CARLOS (US) | 2014-03-13 | — | — | WO | disclosed |
| US-20140024663-A1 | ATB(0,+) AMINO ACID TRANSPORTER AS A DRUG TARGET FOR TREATMENT OF ESTROGEN RECEPTOR-POSITIVE BREAST CANCER | GEORGIA HEALTH SCIENCES UNIVERSITY RES INST INC (US) | 2014-01-23 | — | — | US | disclosed |
| WO-2013119518-A1 | SMALL MOLECULES FOR ISLET EXPANSION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-08-15 | — | — | WO | disclosed |
| US-20080139457-A1 | Therapeutic compositions comprising chorionic gonadotropins and HMG CoA reductase inhibitors | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2007035395-A9 | THERAPEUTIC COMPOSITIONS COMPRISING CHORIONIC GONADOTROPINS AND HMG COA REDUCTASE INHIBITORS | UNIV VIRGINIA COMMONWEALTH (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007035395-A2 | THERAPEUTIC COMPOSITIONS COMPRISING CHORIONIC GONADOTROPINS AND HMG COA REDUCTASE INHIBITORS | VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION (US) | 2007-03-29 | — | — | WO | disclosed |