Hydrochloric Acid

Hydrochloric Acid

SCHEMBL5141967

CCCC=C(C)C(N)=O.Cl.N

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.36
GRIK2 Q13002 1/20 0.36
FAAH O00519 3/20 0.33
BACE1 P56817 1/20 0.33
POLB P06746 1/20 0.32
MEN1 O00255 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
SOAT1 P35610 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CNR1 P21554 1/20 0.31
LMNA P02545 1/20 0.30
ALOX15 P16050 1/20 0.30
BLM P54132 1/20 0.30
PMP22 Q01453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1534217 0.98 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB
Ammonia Solution, Strong SCHEMBL5144020 0.98 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB
SCHEMBL554467 0.95
SCHEMBL554468 0.95
Trimethylammonium SCHEMBL28199924 0.94 GRIK1 (0.33) GRIK1GRIK2FAAHBACE1
Iodide SCHEMBL32659710 0.93 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB
Acetamide SCHEMBL6358174 0.93 LMNA (0.38) GRIK1GRIK2FAAHBACE1POLB
Bromide SCHEMBL29726696 0.93 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB
Bromide SCHEMBL29726693 0.93 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB
Methylamine SCHEMBL4365894 0.93 GRIK1 (0.37) GRIK1GRIK2FAAHBACE1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102428157-B The water-soluble polymers of single mixed thing and the new formulation of stabilization additives that chemistry improves oil recovery injection fluid is can be used for for injecting S.P.C.M. S.A. (FR) 2015-09-09 CN disclosed
US-7250245-B2 Switchable polymer printing plates with carbon bearing ionic and steric stabilizing groups EASTMAN KODAK COMPANY (US) 2007-07-31 US disclosed
US-7077516-B2 Inkjet printing method EASTMAN KODAK COMPANY (US) 2006-07-18 US disclosed
EP-1611213-A1 INKJET INK COMPOSITION AND INK/RECEIVER COMBINATION EASTMAN KODAK COMPANY (US) 2006-01-04 EP disclosed
US-20050260509-A1 Switchable polymer printing plates with carbon bearing ionic and steric stabilizing groups KODAK REALTY INC. 2005-11-24 US disclosed
EP-1413432-B1 Heat-sensitive imaging element for providing lithographic printing plates KODAK POLYCHROME GRAPHICS CO (US) 2005-10-12 EP disclosed
EP-1550551-A2 Method for reducing start up blinding in no-process lithographic printing plates Kodak Polychrome Graphics, LLC (US) 2005-07-06 EP disclosed
US-6908186-B2 Inkjet ink composition and an ink/receiver combination EASTMAN KODAK COMPANY (US) 2005-06-21 US disclosed
US-6844140-B1 Method for reducing start up blinding in no-process lithographic printing plates KODAK POLYCHROME GRAPHICS LLC (US) 2005-01-18 US disclosed
US-6832554-B2 applying to cylinder, imageable coating comprising copolymer of methyl methacrylate, trimethylammoniummethyl methacrylic chloride, and N-(3-aminopropyl)methacrylamide hydrochloride, which changes affinity for printing fluid upon infrared exposure KODAK POLYCHROME GRAPHICS LLC 2004-12-21 US disclosed
US-20030113653-A1 Imaging member containing carbon black and methods of imaging and printing EASTMAN KODAK COMPANY 2003-06-19 US disclosed
EP-1304221-A1 Imaging members containing carbon black and methods of imaging and printing EASTMAN KODAK COMPANY (US) 2003-04-23 EP disclosed
EP-1244548-A2 HEAT-SENSITIVE IMAGING ELEMENT FOR PROVIDING LITHOGRAPHIC PRINTING PLATES Kodak Polychrome Graphics Company Ltd. (US) 2002-10-02 EP disclosed
US-6451500-B1 Imaging member containing heat switchable carboxylate polymer and method of use KODAK POLYCHROME GRAPHICS LLC 2002-09-17 US disclosed
US-6447978-B1 LITHOGRAPHIC PRINTING PLATES THAT REQUIRE NO WET PROCESSING AFTER IMAGING; EXPOSED AREAS ARE RENDERED MORE OLEOPHILIC THAN SAID UNEXPOSED AREAS BY HEAT PROVIDED BY IMAGEWISE EXPOSING KODAK POLYCHROME GRAPHICS LLC 2002-09-10 US disclosed
WO-2001039985-A2 HEAT-SENSITIVE IMAGING ELEMENT FOR PROVIDING LITHOGRAPHIC PRINTING PLATES KODAK POLYCHROME GRAPHICS CO. LTD. (US) 2001-06-07 WO disclosed
EP-0476117-B1 THERMOREVERSIBLE HEAT-THICKENING POLYACRYLAMIDES EASTMAN KODAK CO (US) 1997-02-19 EP disclosed
US-5432245-A Casting layer of aqueous solution of polymer with hydrophobic units of N-/1,1-dimethyl-3-oxobutyl/acrylamide or an N-alkylacrylamide and hydrophilic units of another acrylamide, and heating to thicken and gel the layer EASTMAN KODAK COMPANY (US) 1995-07-11 US disclosed
EP-0476117-A1 THERMOREVERSIBLE HEAT-THICKENING POLYACRYLAMIDES. EASTMAN KODAK CO (US) 1992-03-25 EP disclosed
WO-1991015526-A2 THERMOREVERSIBLE HEAT-THICKENING POLYACRYLAMIDES EASTMAN KODAK COMPANY (US) 1991-10-17 WO disclosed