Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167815 | 0.76 | ALDH1A1 (0.43) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11276340 | 0.72 | CA2 (0.38) | LMNAMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL7252297 | 0.70 | POLB (0.55) | MAPK1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17263340 | 0.68 | ALDH1A1 (0.53) | LMNAMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL480278 | 0.67 | ALDH1A1 (0.73) | LMNAMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL2795967 | 0.67 | ALDH1A1 (0.54) | LMNAMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL23009248 | 0.65 | KDM4E (0.63) | LMNAMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL4760288 | 0.65 | ALDH1A1 (0.53) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11272848 | 0.65 | MTNR1A (0.47) | MAPK1ALDH1A1POLBGAAKDM4E | |
| SCHEMBL25429949 | 0.65 | MEN1 (0.37) | LMNAMAPK1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070078175-A1 | Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof | L'OREAL (FR) | 2007-04-05 | — | — | US | claimed |
| US-20070077215-A1 | Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | L'OREAL (FR) | 2007-04-05 | — | — | US | claimed |
| US-12616681-B2 | Compositions and methods for treating renal injury | CASE WESTERN RESERVE UNIVERSITY (US) | 2026-05-05 | — | — | US | disclosed |
| EP-3883577-B1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | UNIV CASE WESTERN RESERVE (US) | 2026-04-08 | — | — | EP | disclosed |
| US-20260007642-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | UNIV CASE WESTERN RESERVE (US) | 2026-01-08 | — | — | US | disclosed |
| US-20250325524-A1 | COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY | UNIV CASE WESTERN RESERVE (US) | 2025-10-23 | — | — | US | disclosed |
| EP-3267995-B1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | UNIV CASE WESTERN RESERVE (US) | 2025-10-08 | — | — | EP | disclosed |
| US-20250304597-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-10-02 | — | — | US | disclosed |
| US-20250295640-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY | 2025-09-25 | — | — | US | disclosed |
| US-20250243217-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2025-07-31 | — | — | US | disclosed |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | RODEO THERAPEUTICS CORPORATION (US) | 2025-06-24 | — | — | US | disclosed |
| EP-1774958-A1 | Use of phenylfurylmethylthiazolidine-2,4-dione or phenylthienylmethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | L'Oréal (FR) | 2007-04-18 | — | — | EP | disclosed |
| EP-1774958-A1 | Use of phenylfurylmethylthiazolidine-2,4-dione or phenylthienylmethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | L'Oréal (FR) | 2007-04-18 | — | — | EP | disclosed |
| EP-1775294-A1 | Phenyl-furyl-methyl-thiazolidine-2,4-dione or phenyl-thienyl-methyl-thiazolidine-2,4-dione compounds; use for stimulating or inducing keratin fibre growth and/or slowing down their loss; compostions thereof | L'Oréal (FR) | 2007-04-18 | — | — | EP | disclosed |
| EP-1775294-A1 | Phenyl-furyl-methyl-thiazolidine-2,4-dione or phenyl-thienyl-methyl-thiazolidine-2,4-dione compounds; use for stimulating or inducing keratin fibre growth and/or slowing down their loss; compostions thereof | L'Oréal (FR) | 2007-04-18 | — | — | EP | disclosed |
| US-20070078175-A1 | Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof | L'OREAL (FR) | 2007-04-05 | — | — | US | disclosed |
| US-20070078175-A1 | Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof | L'OREAL (FR) | 2007-04-05 | — | — | US | disclosed |
| US-20070078175-A1 | Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof | L'OREAL (FR) | 2007-04-05 | — | — | US | disclosed |
| US-20070077215-A1 | Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | L'OREAL (FR) | 2007-04-05 | — | — | US | disclosed |
| US-20070077215-A1 | Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | L'OREAL (FR) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070077215-A1 | Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening | TYR, KRT18, MITF | LMNA 1994/4885MAPK1 91/4885ALDH1A1 64/4885 |
| US-20250304597-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | LMNA 1481/4885MAPK1 3373/4885ALDH1A1 126/4885 |
| US-12336982-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | HPGD, GCDH, HPGDS | LMNA 1481/4885MAPK1 3373/4885ALDH1A1 126/4885 |
| US-12616681-B2 | Compositions and methods for treating renal injury | PTGIS, PTGS1, PTGS2 | LMNA 2413/4885MAPK1 1486/4885ALDH1A1 145/4885 |
| US-20250295640-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | GCDH, HPGD, UGDH | LMNA 1656/4885MAPK1 3429/4885ALDH1A1 28/4885 |
| US-20070078175-A1 | Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof | KRT18, NGF, FGF1 | LMNA 2000/4885MAPK1 41/4885ALDH1A1 2150/4885 |
| US-20260007642-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | PTGDR, HPGD, PTGDR2 | LMNA 2911/4885MAPK1 731/4885ALDH1A1 110/4885 |
| US-20250243217-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | LMNA 1481/4885MAPK1 3373/4885ALDH1A1 126/4885 |
| US-20250325524-A1 | COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY | PTGS1, GLS, PTGS2 | LMNA 2612/4885MAPK1 3895/4885ALDH1A1 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.