Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21357686 | 1.00 | CYP3A4 (0.36) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Hydrochloric Acid SCHEMBL28977209 | 1.00 | CYP3A4 (0.36) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Water SCHEMBL28537381 | 0.98 | CYP3A4 (0.37) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Hydrochloric Acid SCHEMBL3286109 | 0.98 | CYP3A4 (0.37) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Hydrochloric Acid SCHEMBL71899 | 0.98 | CYP3A4 (0.37) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| SCHEMBL41543 | 0.96 | CYP3A4 (0.39) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Hydrogen Peroxide SCHEMBL3706944 | 0.93 | CYP3A4 (0.36) | CYP3A4TDP1ALDH1A1TP53TAAR1 | |
| Carbon Tetrachloride SCHEMBL29029110 | 0.89 | ALDH1A1 (0.33) | CYP3A4TDP1ALDH1A1TP53 | |
| SCHEMBL5803242 | 0.81 | CYP3A4 (0.49) | CYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL28449243 | 0.80 | CYP3A4 (0.34) | CYP3A4TDP1ALDH1A1TP53TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116130727-A | Preparation method and application of proton exchange membrane of high-temperature fuel cell | 东华大学 | 2023-05-16 | — | — | CN | claimed |
| US-20240082261-A1 | COMPOSITIONS AND USES THEREOF FOR TREATMENT OF IDIOPATHIC PRETERM BIRTH | UNIVERSITY OF SOUTH FLORIDA | 2024-03-14 | — | — | US | disclosed |
| US-11806356-B2 | Compositions and uses thereof for treatment of idiopathic preterm birth | UNIVERSITY OF SOUTH FLORIDA (US) | 2023-11-07 | — | — | US | disclosed |
| EP-4212177-A1 | COMPOSITIONS FOR PROLONGING THE SURVIVAL AFTER ORTHOPIC AND HETEROPIC XENOGENEIC HEART TRANSPLANTATIONS | Reichart, Bruno (DE) | 2023-07-19 | — | — | EP | disclosed |
| CN-116130727-A | Preparation method and application of proton exchange membrane of high-temperature fuel cell | 东华大学 | 2023-05-16 | — | — | CN | disclosed |
| EP-4154912-A1 | DONOR ORGANISM FOR XENOGENEIC ORGAN TRANSPLANTS | Reichart, Bruno (DE) | 2023-03-29 | — | — | EP | disclosed |
| US-20210105999-A1 | COMPOSITIONS FOR PROLONGING THE SURVIVAL AFTER ORTHOTOPIC AND HETEROTOPIC XENOGENEIC HEART, KIDNEY, LUNG OR LIVER TRANSPLANTATIONS | REICHART, BRUNO (DE) | 2021-04-15 | — | — | US | disclosed |
| EP-3773570-A2 | COMPOSITIONS FOR PROLONGING THE SURVIVAL AFTER ORTHOPIC AND HETEROPIC XENOGENEIC HEART, KIDNEY, LUNG OR LIVER TRANSPLANTATIONS | Reichart, Bruno (DE) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019185936-A2 | METHODS AND COMPOSITIONS FOR PROLONGING THE SURVIVAL AFTER ORTHOTOPIC AND HETEROTOPIC XENOGENEIC HEART, KIDNEY, LUNG OR LIVER TRANSPLANTATIONS | REICHART BRUNO (DE) | 2019-10-03 | — | — | WO | disclosed |
| US-8702924-B2 | Electrode for an electrochemical device and method for detecting hydrogen peroxide using the electrode | CHANG GUNG UNIVERSITY (TW) | 2014-04-22 | — | — | US | disclosed |
| US-8653203-B2 | Method for preparing carboxylic polybenzimidazole | CHANG GUNG UNIVERSITY (TW) | 2014-02-18 | — | — | US | disclosed |
| US-8653204-B2 | Carboxylic polybenzimidazole | CHANG GUNG UNIVERSITY (TW) | 2014-02-18 | — | — | US | disclosed |
| US-20120031774-A1 | ELECTRODE FOR AN ELECTROCHEMICAL DEVICE AND METHOD FOR DETECTING HYDROGEN PEROXIDE USING THE ELECTRODE | CHANG GUNG UNIVERSITY (TW) | 2012-02-09 | — | — | US | disclosed |
| US-20120035333-A1 | CARBOXYLIC POLYBENZIMIDAZOLE | CHANG GUNG UNIVERSITY (TW) | 2012-02-09 | — | — | US | disclosed |
| US-20120035334-A1 | METHOD FOR PREPARING CARBOXYLIC POLYBENZIMIDAZOLE | CHANG GUNG UNIVERSITY (TW) | 2012-02-09 | — | — | US | disclosed |
| EP-0973895-A1 | TRANSCRIPTION FACTOR ISLET-BRAIN 1 (IB1) | Nicod, Pascal (CH) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998044106-A1 | TRANSCRIPTION FACTOR ISLET-BRAIN 1 (IB1) | NICOD, PASCAL (CH) | 1998-10-08 | — | — | WO | disclosed |