Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN known ✓ | Q96SW2 | 1/20 | 0.30 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.30 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.30 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL5694442 | 1.00 | — | — | |
| Acrylamide SCHEMBL659888 | 0.97 | — | — | |
| Acrylamide SCHEMBL20561989 | 0.94 | TSHR (0.69) | TSHRALDH1A1FGFR4LMNATDP1 | |
| Acrylic Acid SCHEMBL28227634 | 0.92 | ALDH1A1 (0.58) | TSHRALDH1A1FGFR4LMNAALOX15 | |
| Acrylamide SCHEMBL20515124 | 0.91 | ALDH1A1 (0.65) | TSHRALDH1A1FGFR4LMNATDP1 | |
| Acrylic Acid SCHEMBL27675250 | 0.88 | ALDH1A1 (0.61) | TSHRALDH1A1FGFR4LMNATDP1 | |
| Acrylamide SCHEMBL28037683 | 0.87 | — | — | |
| Acrylamide SCHEMBL5739810 | 0.87 | — | — | |
| Acrylamide SCHEMBL2515155 | 0.87 | — | — | |
| Acrylamide SCHEMBL332483 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278505-B1 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2006-04-19 | — | — | EP | claimed |
| US-6696053-B1 | FREE OF LARGE AMOUNTS OF FATTY ALCOHOL; STYLING | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-02-24 | — | — | US | claimed |
| EP-1278505-A2 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2003-01-29 | — | — | EP | claimed |
| WO-2001082879-A2 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2001-11-08 | — | — | WO | claimed |
| CN-108472930-B | Three-dimensional metal insulation component | 哈金森公司 | 2020-07-21 | — | — | CN | disclosed |
| EP-1278505-B1 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2006-04-19 | — | — | EP | disclosed |
| US-6696053-B1 | FREE OF LARGE AMOUNTS OF FATTY ALCOHOL; STYLING | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2004-02-24 | — | — | US | disclosed |
| CN-1462184-A | Hair dye composition for dressing hair | COSOBEAUTY LTD (JP) | 2003-12-17 | — | — | CN | disclosed |
| US-20030145395-A1 | Hair dye compositions for dressing the hair | COSMOBEAUTY CO., LTD. (JP) | 2003-08-07 | — | — | US | disclosed |
| EP-1278505-A2 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001082879-A2 | LEAVE-ON OR RINSE-OUT HAIR CARE CONDITIONER COMPOSITIONS CONTAINING SILICONE QUATERNARY COMPOUNDS AND THICKENERS | UNILEVER PLC (GB) | 2001-11-08 | — | — | WO | disclosed |
| US-3920599-A | Latices of dially dimethyl ammonium chloride/acrylamide polymers | NALCO CHEMICAL CO | 1975-11-18 | — | — | US | disclosed |