Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 16/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.39 |
| ▸ | FAP | Q12884 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5079153 | 1.00 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| Hydrochloric Acid SCHEMBL27529254 | 1.00 | DPP4 (0.40) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL353690 | 0.98 | DPP4 (0.41) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL1445688 | 0.98 | DPP4 (0.41) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL354706 | 0.98 | DPP4 (0.41) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL4955812 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL4948911 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9DPP7FAP | |
| Fumaric Acid SCHEMBL27529255 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL27755779 | 0.86 | DPP4 (0.49) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL7056083 | 0.83 | DPP4 (0.35) | DPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1332954-C | Effector of dipeptidyl peptidase IV | PROBIODRUG GES FUER ARZNEIM (GB) | 2007-08-22 | — | — | CN | disclosed |
| EP-1398030-B1 | Dipeptidyl peptidase IV effectors | PROSIDION LTD (GB) | 2006-09-06 | — | — | EP | disclosed |
| EP-1428533-B1 | Use of thiazolidine-derivatives as antihyperglycemic agents | PROSIDION LTD (GB) | 2006-08-16 | — | — | EP | disclosed |
| CN-1637018-A | Novel effectors of dipeptidyl peptidase IV | PROSIDION LTD (GB) | 2005-07-13 | — | — | CN | disclosed |
| EP-1304327-B1 | Glutamine-thiazolidide and -pyrrolidide and their use as dipeptidylpeptidase IV inhibitors | PROSIDION LTD (GB) | 2005-02-23 | — | — | EP | disclosed |
| EP-1215207-B1 | Organic Salts of isoleucyl-thiazolidine and -pyrrolidine and their use as dipeptidylpeptidase inhibitors | PROBIODRUG AG (DE) | 2004-07-28 | — | — | EP | disclosed |
| EP-1214936-B1 | Use of thiazolidin- or pyrrolidin-derivatives of aminoacids as antihyperglycemic agents | PROBIODRUG AG (DE) | 2004-07-28 | — | — | EP | disclosed |
| EP-1428533-A2 | Use of thiazolidine- or pyrrolidine-derivatives of aminoacids as antihyperglycemic agents | Probiodrug AG (DE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1398030-A2 | Dipeptidyl peptidase IV effectors | Probiodrug AG (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1082314-B1 | NEW DIPEPTIDYL PEPTIDASE IV EFFECTORS | PROBIODRUG AG (DE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1304327-A2 | Glutamine-thiazolidide and -pyrrolidide and their use as dipeptidylpeptidase IV inhibitors | Probiodrug AG (DE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1215207-A2 | Salts of isoleucyl-thiazolidine and -pyrrolidine and their use as dipeptidylpeptidase inhibitors | Probiodrug AG (DE) | 2002-06-19 | — | — | EP | disclosed |
| EP-1214936-A2 | Use of thiazolidin- or pyrrolidin-derivatives of aminoacids as antihyperglycemic agents | Probiodrug AG (DE) | 2002-06-19 | — | — | EP | disclosed |
| CN-1303381-A | Novel effectors of dipeptidyl peptidase IV | PROBIODRUG GES FUER ARZNEIM (DE) | 2001-07-11 | — | — | CN | disclosed |