Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Buformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buformin SCHEMBL3644254 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL749659 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL15669256 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL4235633 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL4656049 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL3455307 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL8432153 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL1048416 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL22436277 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL5483046 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 1215191 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086659-A1 | TILTING AID FOR ROLLING WALKERS | GRONEN MARKUS (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018077653-A1 | VIRTUAL ARTICULATOR | SICAT GMBH & CO. KG (DE) | 2018-05-03 | — | — | WO | claimed |
| WO-2018077419-A1 | SHEAR BLADE FOR A CUTTING DEVICE | LUKAS HYDRAULIK GMBH (DE) | 2018-05-03 | — | — | WO | claimed |
| WO-2018077418-A1 | SHEAR BLADE AND CUTTING DEVICE | LUKAS HYDRAULIK GMBH (DE) | 2018-05-03 | — | — | WO | claimed |
| WO-2018078549-A1 | METHOD AND DEVICE FOR PRODUCING A ROTISSERIE MEAT PRODUCT, A MEAT PRODUCT OF THIS TYPE AND DEVICE FOR CUTTING OFF PIECES THEREOF | PIRES DE SOUSA JOAO MANUEL (CH) | 2018-05-03 | — | — | WO | claimed |
| WO-2018077769-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2018-05-03 | — | — | WO | claimed |
| EP-3311979-A1 | BLOW-MOULDING MACHINE WITH CHANGING ROBOT AND METHOD FOR THE OPERATION OF SAME | Krones AG (DE) | 2018-04-25 | — | — | EP | claimed |
| EP-3312250-A1 | SINGLE-SIDED PRESSURE-SENSITIVE ADHESIVE VAPOUR BARRIER | Uzin Tyro AG (CH) | 2018-04-25 | — | — | EP | claimed |
| EP-3054081-B1 | LOCK RING | WEATHERFORD TECH HOLDINGS LLC (US) | 2018-04-25 | — | — | EP | claimed |
| EP-3312848-A1 | METHOD FOR MANUFACTURING A FLAT CONDUCTOR ASSEMBLY | ALANOD GmbH & Co. KG (DE) | 2018-04-25 | — | — | EP | claimed |
| EP-0001593-A1 | Process for the preparation of butenediol diacetate | BASF Aktiengesellschaft (DE) | 1979-05-02 | — | — | EP | claimed |
| EP-0001444-A1 | Disconnecting switch for high tension | BROWN, BOVERI & CIE Aktiengesellschaft Mannheim (DE) | 1979-04-18 | — | — | EP | claimed |
| EP-0001279-A1 | Imidazole derivatives their synthesis and their pharmaceutical formulations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-04-04 | — | — | EP | claimed |
| EP-0001227-A1 | Device for processing films in consecutive steps | Imperial Foto Industries Ltd. (IE) | 1979-04-04 | — | — | EP | claimed |
| EP-0001050-A1 | Liquid level measuring device | VDO Adolf Schindling AG (DE) | 1979-03-21 | — | — | EP | claimed |
| EP-0000960-A1 | Shifting device for multistage gear boxes in motor vehicles | ROBERT BOSCH GMBH (DE) | 1979-03-07 | — | — | EP | claimed |
| EP-0000549-A1 | Endoprosthesis | BAYER AG (DE) | 1979-02-07 | — | — | EP | claimed |
| EP-0000608-A1 | Process for the preparation of copolymers and coating compositions, such as binders for lacquers, that are dissolvable in organic solvents and that contain hydroxyl groups | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-02-07 | — | — | EP | claimed |
| EP-0000193-A1 | Coating compositions | BAYER AG (DE) | 1979-01-10 | — | — | EP | claimed |
| EP-0000117-A1 | Apparatus for foaming or spraying liquids | Wella Aktiengesellschaft (DE) | 1979-01-10 | — | — | EP | claimed |