Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Buformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buformin SCHEMBL3644254 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL6018 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL15669256 | 1.00 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL4235633 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL4656049 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL3455307 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL8432153 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL1048416 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL22436277 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL5483046 | 0.98 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3949791-B1 | BIODEGRADABLE HOOK-TYPE MOLDED SURFACE FASTENER WITH OUTSTANDING MOLDABILITY | KURARAY FASTENING CO LTD (JP) | 2023-11-01 | — | — | EP | claimed |
| EP-3768557-B1 | WING FOLDING MECHANISM FOR A DEVICE ATTACHED OUTSIDE A VEHICLE | VOLVO TRUCK CORP (SE) | 2022-09-07 | — | — | EP | claimed |
| EP-2666032-B1 | METHODS AND ARRANGEMENTS FOR DETECTING WEAK SIGNALS | RADAREAL OY (FI) | 2016-07-13 | — | — | EP | claimed |
| EP-2293943-B1 | IMAGE PROCESSING METHOD, IMAGE PROCESSING APPARATUS, IMAGE FORMING APPARATUS, IMAGE FORMING SYSTEM, AND STORAGE MEDIUM | RICOH CO LTD (JP) | 2015-07-29 | — | — | EP | claimed |
| EP-0938390-B1 | DEVICE AND METHOD FOR STRAIGHTENING OUT DAMAGED METAL AND PLASTIC ELEMENTS | SARRION SANCHEZ CHRISTIAN (FR) | 2000-07-12 | — | — | EP | claimed |
| EP-0406856-B1 | Stabilized FGF composition and production thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-03-02 | — | — | EP | claimed |
| EP-0054303-B1 | SEMICONDUCTOR INTEGRATED CIRCUIT | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1986-06-11 | — | — | EP | claimed |
| EP-4143393-B1 | REPLACEABLE OUTLET FILTER | EXPRESS INSTALLATEUR E U (AT) | 2024-06-05 | — | — | EP | disclosed |
| EP-4172546-B1 | METHOD OF MANUFACTURING A FIN PLATE HEAT EXCHANGER AND FIN PLATE HEAT EXCHANGER | LINDE GMBH (DE) | 2024-06-05 | — | — | EP | disclosed |
| EP-4172546-A1 | METHOD FOR PRODUCING A PLATE-FIN HEAT EXCHANGER, AND PLATE-FIN HEAT EXCHANGER | Linde GmbH (DE) | 2023-05-03 | — | — | EP | disclosed |
| EP-4143393-A1 | EXCHANGEABLE DRAIN SIEVE | Express Installateur E.U. (AT) | 2023-03-08 | — | — | EP | disclosed |
| EP-4104035-A1 | OPERATING DEVICE AND METHOD FOR OPERATING AN OPERATING DEVICE | INVENTUS Engineering GmbH (AT) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021259516-A1 | METHOD FOR PRODUCING A PLATE-FIN HEAT EXCHANGER, AND PLATE-FIN HEAT EXCHANGER | LINDE GMBH (DE) | 2021-12-30 | — | — | WO | disclosed |
| EP-1256169-A2 | CIRCUIT CONFIGURATION FOR THE DISCHARGE CONTROLLED BY MEANS OF A CONTROL UNIT OF A CAPACITOR FROM A HIGH VOLTAGE TO A LOW VOLTAGE | Infineon Technologies AG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001061851-A2 | CIRCUIT CONFIGURATION FOR THE DISCHARGE CONTROLLED BY MEANS OF A CONTROL UNIT OF A CAPACITOR FROM A HIGH VOLTAGE TO A LOW VOLTAGE | INFINEON TECHNOLOGIES AG (DE) | 2001-08-23 | — | — | WO | disclosed |
| EP-0709611-A1 | Insertion device for a gas pipe in a building | Jeschke, Immanuel (DE) | 1996-05-01 | — | — | EP | disclosed |
| EP-0586793-B1 | Half-bridge configuration | GRUENDL & HOFFMANN (DE) | 1996-02-07 | — | — | EP | disclosed |
| EP-0589390-A1 | Receiver for phase shift modulated carrier signals | SIEMENS AKTIENGESELLSCHAFT (DE) | 1994-03-30 | — | — | EP | disclosed |
| EP-0586793-A2 | Half-bridge configuration | GRÜNDL UND HOFFMANN GmbH GESELLSCHAFT FÜR ELEKTROTECHNISCHE ENTWICKLUNGEN (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0243805-A2 | Process for the production of shaped articles from granules based on silicon, germanium or mixed crystals of these elements | HELIOTRONIC Forschungs- und Entwicklungsgesellschaft für Solarzellen-Grundstoffe mbH (DE) | 1987-11-04 | — | — | EP | disclosed |