Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Bunitrolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.97 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.97 |
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.97 |
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.65 |
| ▸ | CASR known ✓ | P41180 | 4/20 | 0.65 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.65 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.65 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.65 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.65 |
| ▸ | ADRB3 known ✓ | P13945 | 1/20 | 0.65 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.61 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.56 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.56 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.56 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bunitrolol SCHEMBL142695 | 1.00 | HTR1A (0.97) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Bunitrolol SCHEMBL142696 | 1.00 | HTR1A (0.97) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Bunitrolol SCHEMBL6506350 | 0.99 | HTR1A (1.00) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Bunitrolol SCHEMBL34721 | 0.99 | HTR1A (1.00) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Bunitrolol SCHEMBL29354749 | 0.99 | HTR1A (1.00) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Bunitrolol SCHEMBL34720 | 0.99 | HTR1A (1.00) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10650914 | 0.88 | HTR1A (0.81) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| Penirolol SCHEMBL1254596 | 0.87 | HTR1A (0.79) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL11747215 | 0.87 | HTR1A (0.79) | HTR1AADRA2AADRA2BMAOAHTR2B | |
| SCHEMBL10592687 | 0.87 | HTR1A (0.78) | HTR1AADRA2AADRA2BMAOAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1322 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122040175-A | Advanced pressure relief method for parallel drilling of roadway | 济宁市煤矿安全生产监测监控中心 | 2026-05-15 | — | — | CN | claimed |
| CN-122046824-A | Method and system for representing aircraft panel assembly stress distribution balance sub-region | 北京科技大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122048856-A | Damaged tray detection and identification method, system and device | 深圳粤十冷链机器人有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-121723117-B | Pipeline displacement stress prediction method, device, storage medium and equipment | 大唐东北电力试验研究院有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122014722-A | Multi-source sensing oil cylinder clamping stress non-uniformity prevention control method | 深圳市博硕科技股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-121580589-A | Shear-resistant-slip constitutive calculation method for split bolts in double-steel-plate shear wall | 天津大学 | 2026-02-27 | — | — | CN | claimed |
| US-12387956-B2 | Systems and methods for controlling non-uniformity | APPLIED MATERIALS, INC. (US) | 2025-08-12 | — | — | US | claimed |
| CN-120163324-A | Efficient and accurate construction system for curve inclined bridge based on intelligent perception and cooperative control | 盐城市交通投资建设控股集团有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-120028486-A | Method for evaluating drought resistance and drought resistance gene effect of transgenic corn field | 新疆维吾尔自治区农业科学院 | 2025-05-23 | — | — | CN | claimed |
| CN-120007253-A | Explosion pre-pressure relief and anti-impact method for island working face of mine with high gas rock burst | 安徽理工大学 | 2025-05-16 | — | — | CN | claimed |
| CN-114459648-A | Multi-mode Lamb wave data fusion-based baseline-free stress online monitoring system and monitoring method | 哈尔滨工业大学 | 2022-05-10 | — | — | CN | claimed |
| CN-114320293-A | Coal pillar type rock burst control method based on electric pulse | 辽宁工程技术大学 | 2022-04-12 | — | — | CN | claimed |
| CN-114216583-A | SH guided wave-based temperature stress online monitoring system and monitoring method thereof | 北京大学 | 2022-03-22 | — | — | CN | claimed |
| CN-114215183-A | Construction method for realizing space special-shaped structure pouring by using UHPC material | 中交第三航务工程局有限公司 | 2022-03-22 | — | — | CN | claimed |
| CN-114092293-A | Mine rock and soil industry emergency linkage monitoring system and method based on precise positioning | 山东泽明能源科技有限公司 | 2022-02-25 | — | — | CN | claimed |
| CN-114008335-A | Washer fastening structure | 株式会社松尾工业所 | 2022-02-01 | — | — | CN | claimed |
| CN-215678149-U | Glass internal stress on-line measuring device | 江苏华东耀皮玻璃有限公司 | 2022-01-28 | — | — | CN | claimed |
| CN-113967106-A | Orbital defect prosthesis and processing technology thereof | 苏州诺普再生医学有限公司 | 2022-01-25 | — | — | CN | claimed |
| CN-113962837-A | Mine geotechnical engineering monitoring and evaluation emergency feedback system and method | 山东泽明能源科技有限公司 | 2022-01-21 | — | — | CN | claimed |
| CN-110683424-B | Uneven stress eliminating device for textile tows | 神马实业股份有限公司 | 2022-01-21 | — | — | CN | claimed |