Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6131227

Cl.N=CN(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB known ✓ P27338 1/20 0.32
GAA known ✓ P10253 1/20 0.31
HSP90AA1 known ✓ P07900 1/20 0.30
ALDH1A1 P00352 5/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ALOX15 P16050 1/20 0.35
CYP3A4 P08684 2/20 0.33
MAPT P10636 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HTT P42858 2/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HPGD P15428 2/20 0.31
LTA4H P09960 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL304901 0.97 ALDH1A1 (0.36) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL10706531 0.73 ALDH1A1 (0.39) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL17151499 0.70 NPSR1 (0.39) ALDH1A1NPSR1ALOX15MAPTL3MBTL1
SCHEMBL5637953 0.70 ALDH1A1 (0.37) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL14289162 0.70 MEN1 (0.42) ALDH1A1NPSR1ALOX15MAPTL3MBTL1
SCHEMBL2960795 0.69 MEN1 (0.40) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL5516786 0.69 ALDH1A1 (0.42) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL43388 0.69 ALDH1A1 (0.42) ALDH1A1NPSR1ALOX15CYP3A4MAPT
Benzene SCHEMBL988303 0.69 ALDH1A1 (0.41) ALDH1A1NPSR1ALOX15CYP3A4MAPT
SCHEMBL152112 0.69 ALDH1A1 (0.41) ALDH1A1NPSR1ALOX15CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050106502-A1 Information recording medium and oxonol compound FUJI PHOTO FILM CO., LTD. 2005-05-19 US disclosed
US-6849316-B2 Information recording medium FUJI PHOTO FILM CO., LTD. (JP) 2005-02-01 US disclosed
US-20040115560-A1 Information recording medium FUJI PHOTO FILM CO., LTD. 2004-06-17 US disclosed
US-20040043326-A1 Information recording medium and oxonol compound FUJI PHOTO FILM CO. , LTD. 2004-03-04 US disclosed
US-6685767-B2 GOOD HUE AS WELL AS EXCELLENT COLORFASTNESS TO LIGHT, HUMIDITY, HEAT, AND OXIDATION FUJI PHOTO FILM CO., LTD. (JP) 2004-02-03 US disclosed
US-6670475-B2 A new oxonol dye compound; high heat and light resistance FUJI PHOTO FILM CO., LTD. (JP) 2003-12-30 US disclosed
US-6611367-B1 Dielectric block, silver film, photo-functional film with change in refractive index upon light exposure, and oxygen cut film FUJI PHOTO FILM CO., LTD. (JP) 2003-08-26 US disclosed
US-20030078421-A1 INFORMATION RECORDING MEDIUM FUJIFILM CORPORATION (JP) 2003-04-24 US disclosed
EP-0833314-B1 Information recording medium FUJI PHOTO FILM CO LTD (JP) 2003-01-22 EP disclosed
US-6437887-B1 Optical logic device and optical memory device FUJI PHOTO FILM CO., LTD. (JP) 2002-08-20 US disclosed
US-20020046680-A1 Methine compound, a recording liquid for ink jet, and an ink jet recording method FUJIFILM CORPORATION (JP) 2002-04-25 US disclosed
EP-1035428-A2 Optical logic device and optical memory device Fuji Photo Film Co., Ltd. (JP) 2000-09-13 EP disclosed
US-6060228-A BACKING LAYER CONTAINS A METHINE DYE HAVING SPECIFIC MAXIMUM ABSORPTION WAVELENGTH FUJI PHOTO FILM CO., LTD. (JP) 2000-05-09 US disclosed
US-6020105-A CONTAINING ORGANIC DYE AND QUATERNARY AMMONIUM SALT; DISCOLORATION INHIBITION FUJI PHOTO FILM CO., LTD. (JP) 2000-02-01 US disclosed
EP-0833314-A2 Information recording medium FUJI PHOTO FILM CO., LTD. (JP) 1998-04-01 EP disclosed
US-4179294-A POLYMER MORDANT, ACIDIC PYRAZOLONE-CONTAINING OXONOL DYE, READILY DECOLORIZED BY IMMOBILIZATION FUJI PHOTO FILM CO., LTD. (JP) 1979-12-18 US disclosed
US-4130430-A OXONOL DYE FUJI PHOTO FILM CO., LTD. (JP) 1978-12-19 US disclosed
US-4078933-A OXONOL DYE FUJI PHOTO FILM CO., LTD. (JA) 1978-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030078421-A1 INFORMATION RECORDING MEDIUM CHRM1, CACNA1S, GRIN1 MAOB 412/4885GAA 4841/4885HSP90AA1 4813/4885
US-20040043326-A1 Information recording medium and oxonol compound KCNH2, KCNN4, KCNN2 MAOB 548/4885GAA 4785/4885HSP90AA1 4884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.