Hydrochloric Acid

Hydrochloric Acid

SCHEMBL618578

Cl.c1ccc(C2CCCCCC2)nc1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA known ✓ P10253 1/20 0.44
DRD4 known ✓ P21917 1/20 0.41
DDB1 known ✓ Q16531 1/20 0.41
CRBN known ✓ Q96SW2 1/20 0.41
OPRM1 known ✓ P35372 1/20 0.41
OPRD1 known ✓ P41143 1/20 0.41
OPRK1 known ✓ P41145 1/20 0.41
CCR5 known ✓ P51681 1/20 0.41
ALDH1A1 P00352 6/20 0.49
MAPK1 P28482 2/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TP53 P04637 1/20 0.49
KDM4E B2RXH2 4/20 0.47
CYP1A2 P05177 2/20 0.44
GRM5 P41594 1/20 0.44
MAPT P10636 2/20 0.42
LMNA P02545 2/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29743227 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29507637 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29743225 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL2056505 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29742299 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL60671 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29507617 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL29742285 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL30853689 0.98 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL1481510 0.96 ALDH1A1 (0.50) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008027350-A2 ACETAMINOPHEN PHARMACEUTICAL COMPOSITIONS AAIPHARMA INC. (US) 2008-03-06 WO claimed
US-5700410-A Method of manufacturing wax matrices NIPPON SHINYAKU CO., LTD. (JP) 1997-12-23 US claimed
EP-2397161-B1 DISINTEGRATING PARTICLE COMPOSITION AND RAPIDLY DISINTEGRATING COMPRESSION-MOLDED MATERIAL COMPRISING SAME FUJI CHEM IND CO LTD (JP) 2019-09-25 EP disclosed
EP-1660050-B1 Ibuprofen-containing fast dissolving tablet WYETH LLC (US) 2016-11-23 EP disclosed
EP-2604256-B1 Multi layer coatings HEXAL AG (DE) 2016-04-13 EP disclosed
US-20140249190-A1 Fast Dissolving Tablet WYETH LLC (US) 2014-09-04 US disclosed
US-20130296385-A1 Fast Dissolving Tablet WYETH LLC (US) 2013-11-07 US disclosed
EP-2604256-A1 Multi layer coatings Hexal AG (DE) 2013-06-19 EP disclosed
US-8202538-B2 Orally disintegrating layered compositions CAPRICORN PHARMA, INC. (US) 2012-06-19 US disclosed
US-20120082721-A1 Enteric coating H E X A L AKTIENGESELLSCHAFT (DE) 2012-04-05 US disclosed
US-20120040001-A1 DISINTEGRATING PARTICLE COMPOSITION AND RAPIDLY DISINTEGRATING COMPRESSION-MOLDED MATERIAL USED THE SAME FUJI CHEMICAL INDUSTRY CO., LTD. (JP) 2012-02-16 US disclosed
EP-1101490-A1 PREPARATION CAPABLE OF RELEASING DRUG AT TARGET SITE IN INTESTINE TANABE SEIYAKU CO., LTD. (JP) 2001-05-23 EP disclosed
EP-1008353-A1 SACCHARIDE-CONTAINING COMPOSITIONS FUJI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-06-14 EP disclosed
US-5837285-A COMPRESSED, SHAPED; XYLITOL AND LACTOSE OR MANNITOL; INFANTS, ELDERLY; STABILITY; CHEMICAL RESISTANCE NIPPON SHINYAKU CO., LTD. (JP) 1998-11-17 US disclosed
US-5700410-A Method of manufacturing wax matrices NIPPON SHINYAKU CO., LTD. (JP) 1997-12-23 US disclosed
EP-0665010-A1 METHOD OF MANUFACTURING WAX MATRICES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1995-08-02 EP disclosed
EP-0497977-B1 GASTRIC PREPARATION NIPPON SHINYAKU CO LTD (JP) 1995-03-15 EP disclosed
EP-0627218-A1 FAST SOLUBLE TABLET NIPPON SHINYAKU COMPANY, LIMITED (JP) 1994-12-07 EP disclosed
US-5368861-A Gastric preparation with sustained release NIPPON SHINYAKU CO., LTD. (JP) 1994-11-29 US disclosed
EP-0497977-A1 GASTRIC PREPARATION NIPPON SHINYAKU COMPANY, LIMITED (JP) 1992-08-12 EP disclosed