Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.32 |
| ▸ | DRD4 known ✓ | P21917 | 4/20 | 0.32 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206866 | 0.98 | CYP11B1 (0.31) | DRD2DRD4CYP11B1CYP11B2 | |
| SCHEMBL7589663 | 0.96 | CYP11B1 (0.31) | DRD2DRD4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL6229776 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL6231455 | 0.81 | DRD2 (0.33) | DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6230236 | 0.77 | CYP19A1 (0.31) | DRD2DRD4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL6231604 | 0.77 | CYP11B1 (0.34) | DRD2DRD4CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL6229737 | 0.76 | HTR2C (0.30) | HTR2C | |
| Hydrochloric Acid SCHEMBL7639893 | 0.75 | MEN1 (0.37) | MEN1KMT2AHTR2C | |
| Hydrochloric Acid SCHEMBL6228693 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL6232298 | 0.75 | CYP11B1 (0.33) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313747-B1 | METHOD FOR PRODUCING ALKYL-BRIDGED LIGAND SYSTEMS AND TRANSITION METAL COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| EP-0745606-B1 | Process for the preparation of bridged metallocene complexes | BASELL POLYOLEFINE GMBH (DE) | 2004-07-28 | — | — | EP | disclosed |
| EP-0643100-B2 | Low temperature impact-resistant composition of semicrystalline propylene homopolymers | BASELL POLYOLEFINE GMBH (DE) | 2003-01-29 | — | — | EP | disclosed |
| EP-1026176-A1 | CATALYST FOR OLEFIN POLYMER PRODUCTION, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING OLEFIN POLYMER | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2000-08-09 | — | — | EP | disclosed |
| EP-0643084-B1 | Process for producing multi-phase homo- or copolymers of C2-C10-alkenes in one reaction zone | BASF AG (DE) | 1999-03-10 | — | — | EP | disclosed |
| EP-0674668-B1 | PROPYLENE HOMOPOLYMERS | BASF AG (DE) | 1997-08-20 | — | — | EP | disclosed |
| EP-0643100-B1 | Low temperature impact-resistant composition of semicrystalline propylene homopolymers | BASF AG (DE) | 1997-07-30 | — | — | EP | disclosed |
| EP-0700406-B1 | RANDOM COPOLYMERS OF PROPYLENE | BASF AG (DE) | 1997-04-16 | — | — | EP | disclosed |
| EP-0755971-A2 | Molding resin, composition containing the same, and processes for producing them | Tosoh Corporation (JP) | 1997-01-29 | — | — | EP | disclosed |
| EP-0745606-A2 | Process for the preparation of bridged metallocene complexes | BASF AKTIENGESELLSCHAFT (DE) | 1996-12-04 | — | — | EP | disclosed |
| EP-0703932-A1 | MULTIPHASE BLOCK COPOLYMERS OF PROPYLENE | BASF Aktiengesellschaft (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0643100-A1 | Low temperature impact-resistant composition of semicrystalline propylene homopolymers | BASF Aktiengesellschaft (DE) | 1995-03-15 | — | — | EP | disclosed |
| EP-0643084-A2 | Process for producing multi-phase homo- or copolymers of C2-C10-alcenes in one reaction zone | BASF Aktiengesellschaft (DE) | 1995-03-15 | — | — | EP | disclosed |
| WO-1994028042-A1 | MULTIPHASE BLOCK COPOLYMERS OF PROPYLENE | BASF AKTIENGESELLSCHAFT (DE) | 1994-12-08 | — | — | WO | disclosed |