Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.45 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.40 |
| ▸ | NR3C1 known ✓ | P04150 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 6/20 | 0.96 |
| ▸ | FABP3 | P05413 | 2/20 | 0.96 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL86091 | 0.98 | FABP4 (1.00) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL28511172 | 0.96 | FABP4 (0.96) | FABP4FABP3FABP5GABRA1GABRB2 | |
| Ammonia Solution, Strong SCHEMBL17985319 | 0.96 | FABP4 (0.96) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL2322601 | 0.96 | FABP4 (0.96) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL28654070 | 0.96 | FABP4 (0.96) | FABP4FABP3FABP5GABRA1GABRB2 | |
| Tetramethylammonium Ion SCHEMBL592343 | 0.92 | FABP4 (0.89) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL12162268 | 0.90 | FABP4 (0.85) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL14022220 | 0.89 | FABP4 (0.82) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL12982857 | 0.89 | FABP4 (0.82) | FABP4FABP3FABP5GABRA1GABRB2 | |
| SCHEMBL2607717 | 0.87 | FABP4 (0.79) | FABP4FABP3FABP5GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229040-B1 | Nucleoside monophosphate derivative, a processor for their production and their use as immunosuppressive drugs | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2003-09-10 | — | — | EP | claimed |
| EP-0763049-B1 | NUCLEOSIDE MONOPHOSPHATE DERIVATIVES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS | HEIDELBERG PHARMA HOLDING GMBH (DE) | 2003-04-02 | — | — | EP | claimed |
| EP-1229040-A2 | Nucleoside monophosphate derivative, a processor for their production and their use as immunosuppressive drugs | Heidelberg Pharma Holding GmbH (DE) | 2002-08-07 | — | — | EP | claimed |
| US-5734042-A | Process for the production of asymmetrical phosphoric acid diesters | BOEHRINGER MANNHEIM GMBH (DE) | 1998-03-31 | — | — | US | claimed |
| EP-0763049-A1 | NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS | Roche Diagnostics GmbH (DE) | 1997-03-19 | — | — | EP | claimed |
| WO-1995032984-A1 | NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS | BOEHRINGER MANNHEIM GMBH (DE) | 1995-12-07 | — | — | WO | claimed |
| US-20250179547-A1 | METHODS AND COMPOSITIONS FOR THE ENZYMATIC PRODUCTION OF PSEUDOURIDINE TRIPHOSPHATE | NATURE'S TOOLBOX, INC. | 2025-06-05 | — | — | US | disclosed |
| US-12247236-B2 | Methods and compositions for the enzymatic production of pseudouridine triphosphate | NATURE'S TOOLBOX, INC. (US) | 2025-03-11 | — | — | US | disclosed |
| EP-4499856-A2 | METHODS AND COMPOSITIONS FOR THE ENZYMATIC PRODUCTION OF PSEUDOURIDINE TRIPHOSPHATE | Nature's Toolbox, Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| US-20240247294-A1 | METHODS AND COMPOSITIONS FOR THE ENZYMATIC PRODUCTION OF PSEUDOURIDINE TRIPHOSPHATE | NATURE'S TOOLBOX, INC. | 2024-07-25 | — | — | US | disclosed |
| US-11959117-B2 | Methods and compositions for the enzymatic production of pseudouridine triphosphate | NATURE'S TOOLBOX, INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230383328-A1 | METHODS AND COMPOSITIONS FOR THE ENZYMATIC PRODUCTION OF PSEUDOURIDINE TRIPHOSPHATE | NATURE'S TOOLBOX, INC. | 2023-11-30 | — | — | US | disclosed |
| WO-2023183921-A2 | METHODS AND COMPOSITIONS FOR THE ENZYMATIC PRODUCTION OF PSEUDOURIDINE TRIPHOSPHATE | NATURE'S TOOLBOX, INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| US-6025343-A | Lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs | ROCHE DIAGNOSTICS GMBH (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5734042-A | Process for the production of asymmetrical phosphoric acid diesters | BOEHRINGER MANNHEIM GMBH (DE) | 1998-03-31 | — | — | US | disclosed |
| US-5679652-A | THERAPY FOR CANCER, INFECTIONS | SCHOTT HERBERT (DE) | 1997-10-21 | — | — | US | disclosed |
| EP-0763049-A1 | NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS | Roche Diagnostics GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995032984-A1 | NEW LIPID ESTERS OF NUCLEOSIDE MONOPHOSPHATES AND THEIR USE AS IMMUNOSUPPRESSIVE DRUGS | BOEHRINGER MANNHEIM GMBH (DE) | 1995-12-07 | — | — | WO | disclosed |
| CN-1028714-C | Herbicidal composition containing pyrimidine derivative as active ingredient | SUMITOMO CHEMICAL CO (JP) | 1995-06-07 | — | — | CN | disclosed |
| US-4788182-A | VIRICIDES | CIBA-GEIGY CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |