Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.40 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.33 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.31 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9066834 | 1.00 | HTR2A (0.40) | HTR2ACA1CA2GPR3ACHE | |
| SCHEMBL8439620 | 0.98 | HTR2A (0.41) | HTR2ACA1CA2GPR3ACHE | |
| SCHEMBL3994179 | 0.97 | HTR2A (0.42) | HTR2ACA1CA2GPR3ACHE | |
| Hydrochloric Acid SCHEMBL6065450 | 0.93 | HTR2A (0.40) | HTR2ACA1CA2GPR3ACHE | |
| Hydrochloric Acid SCHEMBL7642652 | 0.93 | HTR2A (0.40) | HTR2ACA1CA2GPR3ACHE | |
| Hydrochloric Acid SCHEMBL7939927 | 0.93 | HTR2A (0.40) | HTR2ACA1CA2GPR3ACHE | |
| SCHEMBL7642438 | 0.82 | ALDH1A1 (0.37) | HTR2A | |
| Hydrochloric Acid SCHEMBL9163410 | 0.81 | NPC1 (0.36) | HTR2A | |
| SCHEMBL6673853 | 0.80 | HTR2A (0.40) | HTR2ACA1CA2GPR3ACHE | |
| Hydrochloric Acid SCHEMBL9166987 | 0.80 | HTR2A (0.33) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1243838-A | Organic aluminum oxide and use-thereof | PHILIP PETROLEUM CORP (US) | 2000-02-09 | — | — | CN | claimed |
| US-6005061-A | COCATALYST WHICH IS A REACTION PRODUCT OF ALUMINOXANE AND ORGANOBOROXINE AND TRANSITION METAL CONTAINING CATALYST | GEERTS ROLF L (US) | 1999-12-21 | — | — | US | claimed |
| EP-0612753-B1 | Organo-Aluminoxy product and use | PHILLIPS PETROLEUM CO (US) | 1999-06-09 | — | — | EP | claimed |
| EP-0729978-A1 | Polyethylene and method for production thereof | PHILLIPS PETROLEUM COMPANY (US) | 1996-09-04 | — | — | EP | claimed |
| EP-0612753-A1 | Organo-Aluminoxy product and use | PHILLIPS PETROLEUM COMPANY (US) | 1994-08-31 | — | — | EP | claimed |
| US-6683016-B1 | SLURRYING METALLOCENE AND ACTIVATOR, APPLYING SONIC WAVES OR VIBRATION WAVES, WASHING WITH HYDROCARBON SOLVENT, DRYING; EVEN PENETRATION INTO PORE SPACE OF SUPPORT | DAELIM INDUSTRIAL CO., LTD. (KR) | 2004-01-27 | — | — | US | disclosed |
| EP-1042375-B1 | SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH | DAELIM IND CO LTD (KR) | 2004-01-02 | — | — | EP | disclosed |
| US-6509427-B1 | Cocatalyst and Group 4B, 5, or 6 metal complex comprising unsaturated compound with cyclopentadienyl, indenyl, or fluorenyl substituent; addition polymerization of olefins | PHILLIPS PETROLEUM COMPANY | 2003-01-21 | — | — | US | disclosed |
| EP-1042375-A1 | SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH | DAELIM INDUSTRIAL CO., LTD. (KR) | 2000-10-11 | — | — | EP | disclosed |
| WO-2000023483-A1 | SUPPORTED METALLOCENE CATALYST, ITS PREPARATION METHOD AND OLEFIN POLYMERIZATION THEREWITH | DAELIM INDUSTRIAL CO., LTD. (KR) | 2000-04-27 | — | — | WO | disclosed |
| US-5583189-A | USING A CATALYST SYSTEM COMPRISING THE REACTION PRODUCT OF A METALLOCENE COMPOUND, A SOLID ORGANOALUMINOXY PRODUCT AND AN ORGANOMETAL COMPOUND | PHILLIPS PETROLEUM COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| US-5496781-A | OLEFIN POLYMERIZATION | PHILLIPS PETROLEUM COMPANY (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0683179-A1 | Metallocene catalyst systems, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |