Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132755 | 0.98 | NPC1 (0.31) | NPC1HPGDMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL28064771 | 0.94 | PTGS2 (0.34) | — | |
| Hydrochloric Acid SCHEMBL6675000 | 0.94 | PTGS2 (0.34) | — | |
| SCHEMBL27446595 | 0.92 | PTGS2 (0.35) | — | |
| Hydrochloric Acid SCHEMBL7578590 | 0.88 | — | — | |
| SCHEMBL27622482 | 0.85 | — | — | |
| Fluoride SCHEMBL27638227 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL2805247 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL20972490 | 0.76 | NPC1 (0.31) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL1539590 | 0.75 | NPC1 (0.36) | NPC1HPGDMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111448223-B | Polyethylene compositions and articles made therefrom | 埃克森美孚化学专利公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-111372954-B | Preparation of polyethylene (bis) silicon-bridged metallocenes with broad molecular weight distribution and molecular weight | 埃克森美孚化学专利公司 | 2022-06-28 | — | — | CN | disclosed |
| US-11214631-B2 | (Di)silicon bridged metallocenes that produce polyethylene with broad molecular weight distribution and high molecular weight | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2022-01-04 | — | — | US | disclosed |
| US-11130827-B2 | Polyethylene compositions and articles made therefrom | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2021-09-28 | — | — | US | disclosed |
| EP-3877430-A1 | POLYETHYLENE COMPOSITIONS AND ARTICLES MADE THEREFROM | ExxonMobil Chemical Patents Inc. (US) | 2021-09-15 | — | — | EP | disclosed |
| EP-3710491-A1 | (DI)SILICON BRIDGED METALLOCENES THAT PRODUCE POLYETHYLENE BROAD MOLECULAR WEIGHT DISTRIBUTION AND MOLECULAR WEIGHT | ExxonMobil Chemical Patents Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| CN-111448223-A | Polyethylene compositions and articles made therefrom | 埃克森美孚化学专利公司 | 2020-07-24 | — | — | CN | disclosed |
| CN-111372954-A | Preparation of polyethylene (bis) silicon-bridged metallocenes with broad molecular weight distribution and molecular weight | 埃克森美孚化学专利公司 | 2020-07-03 | — | — | CN | disclosed |
| US-20190263953-A1 | Polyethylene Compositions and Articles Made Therefrom | EXXONMOBIL CHEMICAL PATENTS INC. | 2019-08-29 | — | — | US | disclosed |
| US-20190144571-A1 | (Di)Silicon Bridged Metallocenes that Produce Polyethylene with Broad Molecular Weight Distribution and High Molecular Weight | EXXONMOBIL CHEMICAL PATENTS INC. | 2019-05-16 | — | — | US | disclosed |
| EP-1425345-A1 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENES OR LINEAR LOWDENSITY POLYETHYLENES AS IMPACT MODIFIERS | Exxonmobil Chemical Patents Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003033585-A1 | POLYMERIC MEMBRANE COMPOSITIONS | EXXONMOBILE CHEMICAL PATENTS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003000790-A1 | METALLOCENE-PRODUCED VERY LOW DENSITY POLYETHYLENES OR LINEAR LOWDENSITY POLYETHYLENES AS IMPACT MODIFIERS | EXXONMOBIL CHEMICAL PATENTS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144571-A1 | (Di)Silicon Bridged Metallocenes that Produce Polyethylene with Broad Molecular Weight Distribution and High Molecular Weight | MDM4, MAL2, MSI2 | NPC1 4568/4885HPGD 3427/4885MAPK1 1653/4885 |
| US-11214631-B2 | (Di)silicon bridged metallocenes that produce polyethylene with broad molecular weight distribution and high molecular weight | MDM4, MAL2, MSI2 | NPC1 4568/4885HPGD 3427/4885MAPK1 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.