Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CPA3 | P15088 | 3/20 | 0.75 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.70 |
| ▸ | CPA1 | P15085 | 7/20 | 0.68 |
| ▸ | CPB1 | P15086 | 1/20 | 0.68 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.68 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.61 |
| ▸ | MME | P08473 | 1/20 | 0.58 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724759 | 0.98 | CYP1A2 (0.83) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL19821208 | 0.98 | CYP1A2 (0.83) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12494233 | 0.98 | CYP1A2 (0.83) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL11664393 | 0.89 | FOLH1 (0.79) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL4664822 | 0.89 | CYP1A2 (1.00) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12494839 | 0.88 | CYP1A2 (0.68) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12494636 | 0.88 | CYP1A2 (0.68) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12494703 | 0.88 | CYP1A2 (0.68) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL3276235 | 0.88 | CYP1A2 (0.68) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12493651 | 0.88 | CYP1A2 (0.74) | CYP1A2CPA3FOLH1CPA1CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673880-B2 | ETHYLENE (CO)POLYMERS HAVING LOW MOLECULAR WEIGHTS AND NARROW MOLECULAR WEIGHT DISTRIBUTIONS | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2004-01-06 | — | — | US | disclosed |
| EP-0942011-B1 | Multi-stage process for the polymerization of olefins | BASELL POLIOLEFINE SPA (IT) | 2003-05-14 | — | — | EP | disclosed |
| EP-0941997-B1 | Bridged zirconocene compounds, process for their preparation, and their use as catalyst components in the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2002-12-18 | — | — | EP | disclosed |
| US-6479609-B1 | Multi-stage process for the polymerization of olefins | BASELL TECHNOLOGY COMPANY BV (NL) | 2002-11-12 | — | — | US | disclosed |
| US-20020039962-A1 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymerization of olefins | MONTELL TECHNOLOGY COMPANY B.V. | 2002-04-04 | — | — | US | disclosed |
| US-6306791-B2 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymerization of olefins | BASELL TECHNOLOGY COMPANY BV (NL) | 2001-10-23 | — | — | US | disclosed |
| US-20010014751-A1 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymeriaztion of olefins | MONTELL TECHNOLOGY COMPANY B.V. | 2001-08-16 | — | — | US | disclosed |
| US-6262195-B1 | POLYMERIZING ETHYLENE OPTIONALLY WITH ALPHA-OLEFIN IN PRESENCE OF TITANIUM OR VANADIUM COMPOUND CATALYST; CONTACTING PRODUCT WITH COMPOUND TO DEACTIVATE CATALYST, ZIRCOCENE CATALYST AND COCATALYST TO FURTHER POLYMERIZE | MONTELL TECHNOLOGY COMPANY BV (NL) | 2001-07-17 | — | — | US | disclosed |
| US-6232484-B1 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymerization of olefins | MONTELL TECHNOLOGY B.V. (NL) | 2001-05-15 | — | — | US | disclosed |
| EP-0941997-A2 | Bridged zirconocene compounds, process for their preparation, and their use as catalyst components in the polymerization of olefins | Montell Technology Company bv (NL) | 1999-09-15 | — | — | EP | disclosed |
| EP-0942011-A1 | Multi-stage process for the polymerization of olefins | Montell Technology Company bv (NL) | 1999-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020039962-A1 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymerization of olefins | ZRANB2, ZKSCAN2, ZCCHC8 | PTGS1 2639/4885CYP1A2 3435/4885CPA3 4615/4885 |
| US-20010014751-A1 | Bridged zirconocene compounds, process for their preparation and their use as catalyst components in the polymeriaztion of olefins | ZRANB2, ZKSCAN2, ZNF787 | PTGS1 1668/4885CYP1A2 2297/4885CPA3 3697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.