Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 known ✓ | O14649 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411114 | 0.99 | ALDH1A1 (0.42) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| Trifluoromethanesulfonic Acid SCHEMBL16108734 | 0.90 | CYP2C9 (0.36) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL28417957 | 0.87 | ALDH1A1 (0.38) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| Hydrochloric Acid SCHEMBL29110628 | 0.84 | TSHR (0.43) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL28415923 | 0.82 | TSHR (0.44) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| Hydrochloric Acid SCHEMBL2784441 | 0.82 | KDM4E (0.33) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| SCHEMBL9020652 | 0.78 | ALDH1A1 (0.40) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| Hydrochloric Acid SCHEMBL28361068 | 0.77 | CYP2C19 (0.35) | ALDH1A1CYP2C19CYP3A4CYP2C9TSHR | |
| Hydrochloric Acid SCHEMBL28443023 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL9539665 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108690171-B | Water-in-water type cationic polyacrylamide emulsion and preparation method and application thereof | 东营市诺尔化工有限责任公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-114834114-A | Coating film for protecting optical member | 三菱化学株式会社 | 2022-08-02 | — | — | CN | disclosed |
| CN-107531029-B | Active energy ray-curable resin composition, antifogging and antifouling laminate, article and method for producing same, and antifouling method | 迪睿合株式会社 | 2021-04-20 | — | — | CN | disclosed |
| CN-108136746-B | Antifogging laminate, article, method for producing same, and antifogging method | 迪睿合株式会社 | 2020-12-08 | — | — | CN | disclosed |
| EP-0943628-B1 | PROCESS FOR THE PREPARATION OF DISPERSIONS OF WATER-SOLUBLE POLYMERS | HYMO CORP (JP) | 2003-04-23 | — | — | EP | disclosed |
| US-5708071-A | FLOCCULATION, SEWAGE TREATMENT | HYMO CORPORATION (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0183466-B2 | Process for the production of a water-soluble polymer dispersion | HYMO CORP (JP) | 1997-08-20 | — | — | EP | disclosed |
| US-5435922-A | Acrylic quaternary ammonium polymer | NALCO CHEMICAL COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629583-A2 | Method of removing colour from waste water using an aqueous dispersion polymer | NALCO CHEMICAL COMPANY (US) | 1994-12-21 | — | — | EP | disclosed |
| EP-0364175-B1 | Process for the preparation of water-soluble cationic polymer | KYORITSU YUKI CO LTD (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5006590-A | Process for the preparation of dispersion of water-soluble cationic polymer | KYORITSU YUKI CO., LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0183466-B1 | PROCESS FOR THE PRODUCTION OF A WATER-SOLUBLE POLYMER DISPERSION | HYMO CORPORATION (JP) | 1990-08-29 | — | — | EP | disclosed |
| US-4929655-A | CATIONIC POLYMERS, HIGH MOLECULAR WEIGHT, FLOCCULANTS | KYORITSU YUKI CO., LTD. (JP) | 1990-05-29 | — | — | US | disclosed |
| EP-0364175-A2 | Process for the preparation of water-soluble cationic polymer | HYMO CORPORATION (JP) | 1990-04-18 | — | — | EP | disclosed |