Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dabigatran Ethyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.74 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.74 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.74 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.74 |
| ▸ | NQO2 | P16083 | 2/20 | 0.99 |
| ▸ | F2 | P00734 | 19/20 | 0.82 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.82 |
| ▸ | F10 | P00742 | 1/20 | 0.82 |
| ▸ | PLG | P00747 | 1/20 | 0.82 |
| ▸ | PLAT | P00750 | 1/20 | 0.82 |
| ▸ | PROC | P04070 | 1/20 | 0.82 |
| ▸ | HPN | P05981 | 1/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.82 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.82 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.82 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.82 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dabigatran Ethyl Ester SCHEMBL29943506 | 1.00 | NQO2 (0.99) | NQO2F2SLC22A2F10PLG | |
| Dabigatran Ethyl Ester SCHEMBL16912888 | 0.99 | NQO2 (0.97) | NQO2F2SLC22A2F10PLG | |
| Dabigatran Ethyl Ester SCHEMBL29943705 | 0.99 | NQO2 (1.00) | NQO2F2SLC22A2F10PLG | |
| Dabigatran Ethyl Ester SCHEMBL3027080 | 0.99 | NQO2 (1.00) | NQO2F2SLC22A2F10PLG | |
| Dabigatran Ethyl Ester SCHEMBL9901841 | 0.97 | NQO2 (0.96) | NQO2F2SLC22A2F10PLG | |
| Dabigatran Ethyl Ester SCHEMBL16583204 | 0.96 | NQO2 (0.94) | NQO2F2SLC22A2F10PLG | |
| SCHEMBL14696907 | 0.94 | NQO2 (0.90) | NQO2F2SLC22A2F10PLG | |
| SCHEMBL10048254 | 0.93 | NQO2 (0.89) | NQO2F2SLC22A2F10PLG | |
| SCHEMBL4757949 | 0.93 | NQO2 (0.89) | NQO2F2SLC22A2F10PLG | |
| Hydrochloric Acid SCHEMBL6776498 | 0.93 | NQO2 (0.86) | NQO2F2SLC22A2F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150203470-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DABIGATRAN ETEXILATE, AND CRYSTALLINE FORMS OF SAID INTERMEDIATES | INTERQUIM, S.A. (ES) | 2015-07-23 | — | — | US | claimed |
| US-20150011589-A1 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2015-01-08 | — | — | US | claimed |
| WO-2014020555-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2014-02-06 | — | — | WO | claimed |
| WO-2013111163-A2 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2013-08-01 | — | — | WO | claimed |
| WO-2013024384-A1 | IMPROVED PROCESS FOR PREPARATION OF DABIGATRAN ETEXILATE AND ITS NOVEL INTERMEDIATE | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2013-02-21 | — | — | WO | claimed |
| US-10538507-B2 | Preparation process for high-purity dabigatran etexilate | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2020-01-21 | — | — | US | disclosed |
| US-20190152945-A1 | PREPARATION PROCESS FOR HIGH-PURITY DABIGATRAN ETEXILATE | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2019-05-23 | — | — | US | disclosed |
| EP-2834224-B1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES AND SALTS THEREOF | MSN LAB LTD (IN) | 2018-06-06 | — | — | EP | disclosed |
| EP-2649060-B1 | PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES AND ITS SALTS | MSN LAB LTD (IN) | 2017-04-05 | — | — | EP | disclosed |
| US-9365544-B2 | Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates | INTERQUIM, S.A. (ES) | 2016-06-14 | — | — | US | disclosed |
| US-9273030-B2 | Process for the preparation of benzimidazole derivatives and salts thereof | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-03-01 | — | — | US | disclosed |
| US-9212166-B2 | Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof | CADILA HEALTHCARE LIMITED (IN) | 2015-12-15 | — | — | US | disclosed |
| WO-2013111163-A2 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2013-08-01 | — | — | WO | disclosed |
| WO-2013024384-A1 | IMPROVED PROCESS FOR PREPARATION OF DABIGATRAN ETEXILATE AND ITS NOVEL INTERMEDIATE | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2013-02-21 | — | — | WO | disclosed |
| WO-2012027543-A1 | SOLID STATE FORMS OF DABIGATRAN ETEXILATE, DABIGATRAN ETEXILATE MESYLATE AND PROCESSES FOR PREPARATION THEREOF | TEVA PHARMACEUTICALS USA, INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| US-6710055-B2 | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBO QUINOLINE-8-SULFONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG (DE) | 2004-03-23 | — | — | US | disclosed |
| US-20030004181-A1 | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-02 | — | — | US | disclosed |
| US-6469039-B1 | BENZIMIDAZOLES; THROMBIN- INHIBITING ACTIVITY AND THE EFFECT OF EXTENDING THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-10-22 | — | — | US | disclosed |
| US-6414008-B1 | CYNAO- OR AMIDINE-SUBSTITUTED BENZIMIDAZOLES, BENOTHIAZOLES, OR BENZOXAZOLES; 2-(N-(4-AMIDINOPHENYL)AMINOMETHYL)BENZOTHIAZOLES; 2-((4-CYANOPHENYL)OXYMETHYL)IMIDAZOL(4,5-B)PYRIDINES; ANTITHROMBOTICS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-07-02 | — | — | US | disclosed |
| US-6087380-A | ANTITHROMBOTIC BENZIMIDAZOLES; ANTICOAGULANTS; 2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-BENZIMIDAZOL-5-YL-CARBOXYLIC ACIDS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10538507-B2 | Preparation process for high-purity dabigatran etexilate | VKORC1, F2, TFPI | SLC6A2 4655/4885AGTR1 2800/4885SLC6A3 3693/4885 |
| US-20030004181-A1 | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions | F2, TFPI, FGB | SLC6A2 4563/4885AGTR1 773/4885SLC6A3 4850/4885 |
| US-20150203470-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DABIGATRAN ETEXILATE, AND CRYSTALLINE FORMS OF SAID INTERMEDIATES | VKORC1, CYP3A4, TFPI | SLC6A2 4564/4885AGTR1 2186/4885SLC6A3 3045/4885 |
| US-20150011589-A1 | PROCESS FOR THE PREPARATION OF DABIGATRAN ETEXILATE MESYLATE AND POLYMORPHS OF INTERMEDIATES THEREOF | CYP1A2, CYP3A4, CYP2C9 | SLC6A2 2530/4885AGTR1 737/4885SLC6A3 2397/4885 |
| US-20190152945-A1 | PREPARATION PROCESS FOR HIGH-PURITY DABIGATRAN ETEXILATE | VKORC1, F2, TFPI | SLC6A2 4655/4885AGTR1 2800/4885SLC6A3 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.