Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.69 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.67 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.61 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.52 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.50 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL199811 | 1.00 | MAOA (0.69) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2790069 | 1.00 | MAOA (0.69) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2789724 | 1.00 | MAOA (0.69) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28399413 | 1.00 | MAOA (0.69) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10584193 | 1.00 | MAOA (0.69) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2365614 | 0.98 | MAOA (0.67) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL7861380 | 0.98 | MAOA (0.71) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL29380563 | 0.98 | MAOA (0.71) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL372804 | 0.98 | MAOA (0.71) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL640522 | 0.98 | MAOA (0.71) | MAOACHRM2SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050036904-A1 | Methods for eradication of nanobacteria | KAJANDER OLAVI E (FI) | 2005-02-17 | — | — | US | claimed |
| US-6827959-B1 | Quaternary onium having long chain alkyl and aromatic functionality modified phyllosilicates; purifying cereals, grains and animal feeds; adsorbs both aflatoxins and nonaflatoxins; low cost | SUD-CHEMIE AG (DE) | 2004-12-07 | — | — | US | claimed |
| EP-1094711-B1 | METHODS FOR ERADICATION OF NANOBACTERIA | NANOBAC OY (FI) | 2004-11-24 | — | — | EP | claimed |
| US-6706290-B1 | CALCIUM CHELATION DEMINERALIZATION THEN DISINFECTING; PREVENTING KIDNEY, SALIVARY GLAND AND DENTAL PULP STONES AND ATHEROSCLEROSIS | CIFTCIOGLU, NEVA DR. | 2004-03-16 | — | — | US | claimed |
| EP-1094711-A1 | METHODS FOR ERADICATION OF NANOBACTERIA | Kajander, E. Olavi (FI) | 2001-05-02 | — | — | EP | claimed |
| WO-2000001238-A1 | METHODS FOR ERADICATION OF NANOBACTERIA | KAJANDER E OLAVI (FI) | 2000-01-13 | — | — | WO | claimed |
| US-5243110-A | DEHYDROCHLORINATION OF 1,1-BIS(R-PHENYL)-2,2,2-TRICHLOROETHANES | ELF ATOCHEM S.A. (FR) | 1993-09-07 | — | — | US | claimed |
| JP-9316776-A | — | — | None | — | — | JP | disclosed |
| JP-58076517-A | — | — | None | — | — | JP | disclosed |
| EP-2363498-B1 | METHOD FOR QUANTITATIVELY DETERMINING CHOLESTEROL IN LOW-DENSITY LIPOPROTEINS, REAGENT FOR QUANTITATIVE DETERMINATION, AND QUANTITATIVE DETERMINATION KIT | KYOWA MEDEX CO LTD (JP) | 2016-05-25 | — | — | EP | disclosed |
| US-8344175-B2 | Liquid crystal compositions, polymer networks derived therefrom and process for making the same | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-01 | — | — | US | disclosed |
| US-8334393-B2 | Chiral compounds and liquid crystal compositions and polymer networks derived therefrom | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-18 | — | — | US | disclosed |
| US-20120219683-A1 | TOXIN ADSORBENT | SUD-CHEMIE AG (DE) | 2012-08-30 | — | — | US | disclosed |
| EP-0003835-B1 | A HYDROXY-UREA, PROCESS FOR PRODUCING THE SAME AND A PROCESS FOR PRODUCING A PHENYL-SUBSTITUTED N-METHOXY-N-METHYL-UREA | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-03-02 | — | — | EP | disclosed |
| EP-0063872-A1 | Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-03 | — | — | EP | disclosed |
| US-4328166-A | Production of substituted phenylurea | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-05-04 | — | — | US | disclosed |
| US-4263219-A | METHYLATION IN TWO-PHASE REACTION MEDIUM | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-04-21 | — | — | US | disclosed |
| US-4172782-A | ORGANIC QUATERNARY AMMONIUM SALT USED IN ALKULATION OF BENZYLNITRILE WITH AN ORGANIC HALIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-10-30 | — | — | US | disclosed |
| US-4159994-A | AMMONIUM OR ALKALI METAL CARBOXYLATE | UNIBRA SOCIETE ANONYME (BE) | 1979-07-03 | — | — | US | disclosed |
| US-4153624-A | FROM A UREA AND NITROUS ACID, SOLVENTS, PHASE TRANSFER AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |