Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Naphthoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.59 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.95 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.95 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.95 |
| ▸ | CDC25B | P30305 | 2/20 | 0.74 |
| ▸ | LDHA | P00338 | 1/20 | 0.64 |
| ▸ | WDR5 | P61964 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthoic Acid SCHEMBL27641446 | 1.00 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL28110155 | 0.98 | NR4A1 (1.00) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL30233567 | 0.98 | NR4A1 (1.00) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL29352220 | 0.98 | NR4A1 (1.00) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL17258 | 0.98 | NR4A1 (1.00) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL6912565 | 0.95 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL3823412 | 0.95 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL1407017 | 0.95 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL20591191 | 0.95 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA | |
| Naphthoic Acid SCHEMBL9178942 | 0.95 | NR4A1 (0.95) | NR4A1NR4A2NR4A3CDC25BLDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567210-A | 4-ACYL-2-PHENYL-1-OXA-3,4-DIAZOL-5-ONES AS BLOWING AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-28 | — | — | US | claimed |
| EP-0059596-B1 | N-NAPHTHOYLGLYCINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-04-24 | — | — | EP | claimed |
| EP-0059596-A1 | N-Naphthoylglycine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-09-08 | — | — | EP | claimed |
| US-4331613-A | Process for the preparation of trifluoromethylnaphthalenes | BAYER AKTIENGESELLSCHAFT (DE) | 1982-05-25 | — | — | US | claimed |
| US-4272502-A | Process for preparing gaseous hydrogen chloride from dilute aqueous hydrochloric acid | CHEMISCHE WERKE HULS AKTIENGESELLSCHAFT (DE) | 1981-06-09 | — | — | US | claimed |
| JP-4099748-A | — | — | None | — | — | JP | disclosed |
| JP-6009493-A | — | — | None | — | — | JP | disclosed |
| JP-61134364-A | — | — | None | — | — | JP | disclosed |
| EP-3512905-B1 | METHOD FOR PRODUCING A POLYBENZAZOL POLYMER (P) | BASF SE (DE) | 2022-08-24 | — | — | EP | disclosed |
| US-11306053-B2 | Ester compound and lubricating oil base oil | DAISAN KASEI CO., LTD (JP) | 2022-04-19 | — | — | US | disclosed |
| US-20210230096-A1 | ESTER COMPOUND AND LUBRICATING OIL BASE OIL | DAISAN KASEI CO., LTD (JP) | 2021-07-29 | — | — | US | disclosed |
| EP-3512905-A1 | METHOD FOR PRODUCING A POLYBENZAZOL POLYMER (P) | BASF SE (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-4284584-A | REACTING AN ANHYDRIDE WITH AN ALKALI METAL CYANIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1981-08-18 | — | — | US | disclosed |
| US-4272502-A | Process for preparing gaseous hydrogen chloride from dilute aqueous hydrochloric acid | CHEMISCHE WERKE HULS AKTIENGESELLSCHAFT (DE) | 1981-06-09 | — | — | US | disclosed |
| US-4265633-A | Process for the manufacture of vat dyes | CIBA-GEIGY AG (CH) | 1981-05-05 | — | — | US | disclosed |
| US-4209462-A | Method for preparing acyl cyanides | STAUFFER CHEMICAL COMPANY (US) | 1980-06-24 | — | — | US | disclosed |
| US-4143068-A | PROCESS FOR THE PREPARATION OF ACYL CYANIDE COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-03-06 | — | — | US | disclosed |
| US-4069252-A | Process for the preparation of certain acyl cyanide compounds | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4018767-A | 5-ENDO-(1-NAPHTHOYLOXY)-N-(AMINOALKYL) BICYCLO(2.2.1)HEPTANE-2,3-DI-ENDO-CARBOXYLIC ACID IMIDES | BRISTOL-MYERS COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-3980667-A | Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]oc | BRISTOL-MYERS COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306053-B2 | Ester compound and lubricating oil base oil | F12, ELOVL1, HRH1 | HDAC8 2456/4885HSP90AA1 685/4885NR4A1 1730/4885 |
| US-20210230096-A1 | ESTER COMPOUND AND LUBRICATING OIL BASE OIL | F12, ELOVL1, HRH1 | HDAC8 2456/4885HSP90AA1 685/4885NR4A1 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.