Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.44 |
| ▸ | TOP1 known ✓ | P11387 | 3/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.44 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.61 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3717866 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| Hydrochloric Acid SCHEMBL3717864 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| Hydrochloric Acid SCHEMBL8483185 | 1.00 | EP300 (0.61) | EP300FNTAFNTBTERTPTPN1 | |
| Hydrochloric Acid SCHEMBL27793446 | 0.98 | EP300 (0.59) | EP300FNTAFNTBTERTPTPN1 | |
| Hydrochloric Acid SCHEMBL5558998 | 0.98 | EP300 (0.64) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL1126330 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL21568 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL21570 | 0.98 | EP300 (0.63) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL811699 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 | |
| SCHEMBL22151487 | 0.96 | EP300 (0.67) | EP300FNTAFNTBTERTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101781319-B | Cephalosporin derivative containing substituted triazole | KBP BIOSCIENCES CO LTD | 2012-12-26 | — | — | CN | claimed |
| CN-101781319-A | Cephalosporin derivative containing substituted triazole | SHANDONG XUANZHU MEDICAL TECHN | 2010-07-21 | — | — | CN | claimed |
| CN-112986471-B | Detection method of cefotiam hydrochloride related substances for injection | 重庆圣华曦药业股份有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-112986471-A | Detection method of cefotiam hydrochloride related substance for injection | 重庆圣华曦药业股份有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107383063-B | Novel crystal form of cefotiam hydrochloride and preparation method | 浙江永宁药业股份有限公司 | 2020-07-31 | — | — | CN | disclosed |
| CN-108299469-B | Preparation method of cefotiam hydrochloride | 重庆常捷医药有限公司 | 2020-07-14 | — | — | CN | disclosed |
| CN-109517001-B | Preparation method of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-109384800-B | Preparation method of cefotiam hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-110563749-A | Preparation method of cefotiam hydrochloride compound | 山东罗欣药业集团恒欣药业有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-106336418-B | A kind of solid-phase synthesis of cefotaxime hydrochloride | 上海上药新亚药业有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-109160924-A | Two water cefotiam hydrochloride compounds of one kind and its drug combination preparation | 海南美大制药有限公司 | 2019-01-08 | — | — | CN | disclosed |
| CN-1347884-A | Vinyl-pyrrolidone cynnematin with alkali subtituent | BASILEA PHARMACEUTICA AG (CH) | 2002-05-08 | — | — | CN | disclosed |
| CN-1347883-A | Vinyl-pyrrolidone cynnematin with alkali subtituent | BASILEA PHARMACEUTICA AG (CH) | 2002-05-08 | — | — | CN | disclosed |
| CN-1347882-A | Vinyl-pyrrolidone cynnematin with alkali subtituent | BASLIR PHARMACEUTICALS AG (CH) | 2002-05-08 | — | — | CN | disclosed |
| CN-1325850-A | Acetyl pyrrolidone cephlosporins with basic substitutent group | BASILEA PHARMACEUTICA AG (CH) | 2001-12-12 | — | — | CN | disclosed |
| CN-1306536-A | Propenyl cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 2001-08-01 | — | — | CN | disclosed |
| EP-1090013-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067255-A1 | PROPENYL CEPHALOSPORIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | WO | disclosed |
| US-5935950-A | AN ANTIBIOTIC COMPRISING A PYRIDINIUM RING WHICH CAN HYDROLYZABLE IN VIVO | HOFFMANN-LA ROCHE INC. (US) | 1999-08-10 | — | — | US | disclosed |
| CN-1188112-A | Vinyl-pyrrolidone cephalosporins with basic substituents | HOFFMANN LA ROCHE (CH) | 1998-07-22 | — | — | CN | disclosed |