Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diaminopyrimidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diaminopyrimidine SCHEMBL793660 | 1.00 | HSP90AA1 (0.46) | — | |
| Diaminopyrimidine SCHEMBL6013998 | 0.97 | HSP90AA1 (0.48) | — | |
| Diaminopyrimidine SCHEMBL29389172 | 0.97 | — | — | |
| Diaminopyrimidine SCHEMBL53016 | 0.97 | — | — | |
| Diaminopyrimidine SCHEMBL2744765 | 0.94 | — | — | |
| Diaminopyrimidine SCHEMBL19297740 | 0.94 | — | — | |
| Diaminopyrimidine SCHEMBL15389244 | 0.94 | — | — | |
| Diaminopyrimidine SCHEMBL30978217 | 0.94 | — | — | |
| Diaminopyrimidine SCHEMBL29556978 | 0.94 | — | — | |
| Diaminopyrimidine SCHEMBL29280600 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115678152-B | Thermal aging resistant asphalt modifier and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-11-03 | — | — | CN | claimed |
| CN-116925490-A | Anti-falling-aging resistant agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116925557-A | Anti-falling aging-resistant flame-retardant asphalt and mixture thereof | 中国石油化工股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116925441-A | Anti-stripping and anti-aging agent, and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-116925442-A | Asphalt anti-stripping aging-resistant warm mix agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-24 | — | — | CN | claimed |
| CN-115678297-B | Asphalt stripping-resistant agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115678291-B | Anti-falling agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115678296-B | Asphalt stripping-resistant agent, and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115677267-B | Anti-falling agent, anti-falling bird repellent asphalt mixture and preparation method thereof | 中国石油化工股份有限公司 | 2023-10-10 | — | — | CN | claimed |
| CN-115678289-B | Anti-drop sulfur asphalt and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-114479365-B | Anti-shedding agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-01-10 | — | — | CN | claimed |
| CN-114477835-B | Anti-scattering agent, anti-scattering flame-retardant asphalt mixture and preparation method thereof | 中国石油化工股份有限公司 | 2023-01-10 | — | — | CN | claimed |
| CN-114477835-A | Anti-flying powder, anti-flying flame-retardant asphalt mixture and preparation method thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114479488-A | Anti-stripping agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114479489-A | Anti-stripping sulfur asphalt and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114479365-A | Anti-shedding agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114479487-A | Anti-shedding agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-107848987-A | Process for producing nitrogen-containing heterocyclic compound and intermediate therefor | 富士胶片株式会社 | 2018-03-27 | — | — | CN | claimed |
| CN-107050030-A | Selective histamine H 4 receptor antagonist for treating vestibular disorder | 国立健康与医学研究所 | 2017-08-18 | — | — | CN | claimed |
| CN-106459007-A | Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient | 韩国化学研究院 | 2017-02-22 | — | — | CN | claimed |