Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.40 |
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.34 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.34 |
| ▸ | ITGB3 known ✓ | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B known ✓ | P08514 | 1/20 | 0.34 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.34 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GGT1 | P19440 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL66178 | 0.85 | TDP1 (0.55) | TDP1ATMELANEBCHEALDH1A1 | |
| SCHEMBL31474595 | 0.85 | TDP1 (0.69) | TDP1ATMELANEBCHEALDH1A1 | |
| SCHEMBL29376230 | 0.85 | TDP1 (0.55) | TDP1ATMELANEBCHEALDH1A1 | |
| SCHEMBL33914 | 0.85 | TDP1 (0.69) | TDP1ATMELANEBCHEALDH1A1 | |
| Ethylene SCHEMBL11046108 | 0.83 | TDP1 (0.54) | TDP1ATMELANEBCHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL3806196 | 0.83 | ATM (0.39) | TDP1ATMELANEBCHEKMT2A | |
| SCHEMBL18421915 | 0.81 | ATM (0.40) | TDP1ATMELANEBCHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL10613194 | 0.81 | ATM (0.37) | TDP1ATMELANEPTGS2KMT2A | |
| SCHEMBL15836534 | 0.80 | ATM (0.50) | TDP1ATMELANEKMT2AGAA | |
| SCHEMBL10537603 | 0.79 | TDP1 (0.54) | TDP1ATMELANEBCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343338-B1 | NITRILE COPOLYMER LATEX COMPOSITION AND NITRILE COPOLYMER RUBBER COMPOSITION | ZEON CORP (JP) | 2018-07-11 | — | — | EP | disclosed |
| US-9926445-B2 | Nitrile copolymer rubber composition | ZEON CORPORATION (JP) | 2018-03-27 | — | — | US | disclosed |
| EP-2937382-B1 | NITRILE COPOLYMER RUBBER COMPOSITION | ZEON CORP (JP) | 2017-10-25 | — | — | EP | disclosed |
| EP-2671914-B1 | NITRILE RUBBER COMPOSITION, CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER PRODUCT | ZEON CORP (JP) | 2017-07-12 | — | — | EP | disclosed |
| US-20150322254-A1 | NITRILE COPOLYMER RUBBER COMPOSITION | ZEON CORPORATION (JP) | 2015-11-12 | — | — | US | disclosed |
| EP-2937382-A1 | NITRILE COPOLYMER RUBBER COMPOSITION | Zeon Corporation (JP) | 2015-10-28 | — | — | EP | disclosed |
| US-20150099841-A1 | METHOD OF PRODUCTION OF NITRILE COPOLYMER RUBBER COMPOSITION | ZEON CORPORATION (JP) | 2015-04-09 | — | — | US | disclosed |
| EP-2824140-A1 | METHOD FOR PRODUCING NITRILE COPOLYMER RUBBER COMPOSITION | Zeon Corporation (JP) | 2015-01-14 | — | — | EP | disclosed |
| EP-2671914-A1 | NITRILE RUBBER COMPOSITION, CROSSLINKING NITRILE RUBBER COMPOSITION, AND CROSSLINKED RUBBER PRODUCT | Zeon Corporation (JP) | 2013-12-11 | — | — | EP | disclosed |
| US-8563644-B2 | Nitrile copolymer rubber composition and nitrile copolymer latex composition | ZEON CORPORATION (JP) | 2013-10-22 | — | — | US | disclosed |
| EP-2548919-A1 | NITRILE COPOLYMER RUBBER COMPOSITION FOR HOSE AND CROSSLINKED MATERIAL | Zeon Corporation (JP) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011150920-A3 | HEAT EXCHANGER | TFC COOLING PRODUCTS E.K. (DE) | 2012-05-10 | — | — | WO | disclosed |
| EP-2130868-B1 | NITRILE COPOLYMER RUBBER COMPOSITION AND NITRILE COPOLYMER LATEX COMPOSITION | ZEON CORP (JP) | 2011-11-30 | — | — | EP | disclosed |
| EP-2343338-A1 | NITRILE COPOLYMER LATEX COMPOSITION AND NITRILE COPOLYMER RUBBER COMPOSITION | Zeon Corporation (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-20100104789-A1 | NITRILE COPOLYMER RUBBER COMPOSITION AND NITRILE COPOLYMER LATEX COMPOSITION | ZEON CORPORATION (JP) | 2010-04-29 | — | — | US | disclosed |
| EP-2130868-A1 | NITRILE COPOLYMER RUBBER COMPOSITION AND NITRILE COPOLYMER LATEX COMPOSITION | ZEON CORPORATION (JP) | 2009-12-09 | — | — | EP | disclosed |