Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6142567 | 0.99 | NPC1 (0.36) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL9247912 | 0.89 | NPC1 (0.38) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL7941393 | 0.89 | NPC1 (0.38) | HTR7HTR2BNPC1RAB9APNMT | |
| SCHEMBL9245113 | 0.88 | NPC1 (0.39) | HTR7HTR2BNPC1RAB9APNMT | |
| SCHEMBL9252131 | 0.88 | NPC1 (0.39) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL2114632 | 0.87 | NPC1 (0.32) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL2115081 | 0.86 | NPC1 (0.41) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL2117246 | 0.85 | PNMT (0.32) | NPC1RAB9APNMT | |
| SCHEMBL8366225 | 0.85 | NPC1 (0.42) | HTR7HTR2BNPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL822061 | 0.84 | PNMT (0.38) | HTR7HTR2BNPC1RAB9APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662895-B2 | comprising polypropylene which is produced in presence of a metallocene transition metal catalyst and an activator; peak melting point temperature below about 110 degrees C., a tensile set of 40% or less, and greater than or equal to about 60% [r]dyads | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-02-16 | — | — | US | claimed |
| US-6982236-B2 | Process to polymerize olefins | UNIVATION TECHNOLOGIES, LLC (US) | 2006-01-03 | — | — | US | claimed |
| US-6897273-B2 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC (US) | 2005-05-24 | — | — | US | claimed |
| EP-1392743-A2 | CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM | Univation Technologies LLC (US) | 2004-03-03 | — | — | EP | claimed |
| US-20040039138-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2004-02-26 | — | — | US | claimed |
| US-6656866-B2 | Metallocene and non-metallocene, homogeneous catalysts, particularly for use in the economical gas and slurry phase processes; spray dried olefin polymerization catalysts | UNIVATION TECHNOLOGIES, LLC | 2003-12-02 | — | — | US | claimed |
| US-20030207762-A9 | CATALYST PREPARATION METHOD | UNIVATION TECHNOLOGIES, LLC | 2003-11-06 | — | — | US | claimed |
| EP-1358216-A2 | START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS | Univation Technologies LLC (US) | 2003-11-05 | — | — | EP | claimed |
| US-6620894-B2 | Calibration; using coordination catalyst | UNIVATION TECHNOLOGIES, LLC | 2003-09-16 | — | — | US | claimed |
| US-20020132937-A1 | Start-up procedure for multiple catalyst polymerization systems | UNIVATION TECHNOLOGIES, LLC | 2002-09-19 | — | — | US | claimed |
| US-20020119890-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2002-08-29 | — | — | US | claimed |
| US-20020103310-A1 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC | 2002-08-01 | — | — | US | claimed |
| WO-2002050127-A2 | START-UP PROCEDURE FOR MULTIPLE CATALYST POLYMERIZATION SYSTEMS | UNIVATION TECHNOLOGIES, LLC (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002046250-A2 | CATALYST COMPOSITION, METHOD OF POLYMERIZATION AND POLYMER THEREFROM | UNIVATION TECHNOLOGIES, LLC (US) | 2002-06-13 | — | — | WO | claimed |
| US-RE36103-E | Process for the preparation of a syndiotactic polyolefin and catalyst therefor | TARGOR GMBH (DE) | 1999-02-16 | — | — | US | claimed |
| EP-0387691-B1 | Process for preparing a syndiotactic polyolefin | HOECHST AG (DE) | 1995-06-28 | — | — | EP | claimed |
| US-5132381-A | Aluminoxane, Hafnium Metallocene | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-07-21 | — | — | US | claimed |
| US-9919300-B2 | 1-hexene production process | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-03-20 | — | — | US | disclosed |
| EP-0708117-A1 | Process for producing copolymer rubber | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0648786-A1 | Process for producing alpha-olefin polymer | Tosoh Corporation (JP) | 1995-04-19 | — | — | EP | disclosed |