SCHEMBL824994

SCHEMBL824994

Cc1cc(F)c(-c2c(Cl)nc3ncnn3c2N2CCC(C)CC2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
LMNA P02545 3/20 0.43
TSHR P16473 4/20 0.41
GLA P06280 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PAX2 Q02962 1/20 0.37
MAPT P10636 1/20 0.37
EGLN2 Q96KS0 1/20 0.37
PDE2A O00408 9/20 0.36
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PKM P14618 1/20 0.36
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL81282 0.92 TSHR (0.41) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL3610355 0.90 TSHR (0.40) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL14044052 0.90 TSHR (0.40) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL3601556 0.88 TSHR (0.39) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL4820371 0.88 TSHR (0.48) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL25616299 0.87 PAX2 (0.39) ALDH1A1LMNATSHRNPSR1PAX2
SCHEMBL25616316 0.87 PAX2 (0.39) ALDH1A1LMNATSHRNPSR1PAX2
SCHEMBL5162613 0.87 EGLN2 (0.47) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL20439999 0.87 EGLN2 (0.42) ALDH1A1LMNATSHRGLANPSR1
SCHEMBL4707370 0.86 GAA (0.40) ALDH1A1LMNATSHRGLANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11647749-B2 Fungicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2023-05-16 US disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-9808007-B2 Fungicidal compositions SYNGENTA PARTICIPATIONS AG (CH) 2017-11-07 US disclosed
US-20170202220-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-07-20 US disclosed
US-20170156326-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2017-06-08 US disclosed
US-20170156325-A1 FUNGICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2017-06-08 US disclosed
US-9642365-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2017-05-09 US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 US disclosed
US-9538755-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2017-01-10 US disclosed
US-9462807-B2 Difenoconazole sterepospmeric composition with reduced phytotoxicity SYNGENTA PARTICIPATIONS AG (CH) 2016-10-11 US disclosed
US-7612018-B2 Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2009-11-03 US disclosed
US-20090030022-A1 Fungicidal Composition Comprising Cyprodinil SYNGENTA CROP PROTECTION, INC. (US) 2009-01-29 US disclosed
US-20090023687-A1 Method for Controlling Phytopathogenic Organisms SYNGENTA CROP PROTECTION, INC. (US) 2009-01-22 US disclosed
US-20080214393-A1 Novel Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-09-04 US disclosed
US-20080214397-A1 Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2008-09-04 US disclosed
US-20080076664-A1 Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. 2008-03-27 US disclosed
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic SYNGENTA CROP PROTECTION, INC. (US) 2008-03-20 US disclosed
US-20070265267-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, INC. (US) 2007-11-15 US disclosed
US-20070244121-A1 Synergistic Fungicidal Compositions SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070015770-A1 Automatic gearbox with infinitely-variable ratio BASF AKTIENGESELLSCHAFT (DE) 2007-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11647749-B2 Fungicidal compositions BROX, RER1, BLVRB ALDH1A1 2185/4885LMNA 2319/4885TSHR 2256/4885
US-20080214393-A1 Novel Insecticides DDT, CYP4F11, ACHE ALDH1A1 140/4885LMNA 2572/4885TSHR 1100/4885
US-20170156325-A1 FUNGICIDAL COMPOSITIONS CYP51A1, ERG28, DPM1 ALDH1A1 678/4885LMNA 2617/4885TSHR 4584/4885
US-20070015770-A1 Automatic gearbox with infinitely-variable ratio MLX, DDX5, DDX1 ALDH1A1 4396/4885LMNA 4790/4885TSHR 2399/4885
US-20170156326-A1 FUNGICIDAL COMPOSITIONS CYP51A1, ERG28, DPM1 ALDH1A1 678/4885LMNA 2617/4885TSHR 4584/4885
US-20170202220-A1 FUNGICIDAL COMPOSITIONS BROX, RER1, BLVRB ALDH1A1 2185/4885LMNA 2319/4885TSHR 2256/4885
US-20090023687-A1 Method for Controlling Phytopathogenic Organisms GRHPR, GUSB, GLO1 ALDH1A1 3155/4885LMNA 3309/4885TSHR 4471/4885
US-20070265267-A1 FUNGICIDAL COMPOSITIONS CRY1, ERG28, DDT ALDH1A1 2319/4885LMNA 945/4885TSHR 3630/4885
US-20070244121-A1 Synergistic Fungicidal Compositions DDT, CRY1, HCN1 ALDH1A1 2503/4885LMNA 1065/4885TSHR 3282/4885
US-20090030022-A1 Fungicidal Composition Comprising Cyprodinil ALOX5, CYP51A1, ALOX15B ALDH1A1 1445/4885LMNA 2752/4885TSHR 4166/4885
US-20080214397-A1 Fungicidal Compositions CYP51A1, CYP1B1, CYP1A1 ALDH1A1 2289/4885LMNA 3545/4885TSHR 4806/4885
US-20080070785-A1 For controlling phytopathogenic diseases; synergistic BROX, EPM2A, MANBA ALDH1A1 4291/4885LMNA 458/4885TSHR 4710/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 ALDH1A1 1601/4885LMNA 946/4885TSHR 4145/4885
US-20080076664-A1 Fungicidal Compositions AKR7A2, CYP51A1, TUBA3C ALDH1A1 1173/4885LMNA 416/4885TSHR 4021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.