Hydrochloric Acid

Hydrochloric Acid

SCHEMBL848632

Cl.OCCOC1CCNCC1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 2/20 0.35
SLC6A2 known ✓ P23975 1/20 0.35
HTR2A known ✓ P28223 1/20 0.35
HTR2C known ✓ P28335 1/20 0.35
HTR7 known ✓ P34969 1/20 0.35
HTR2B known ✓ P41595 1/20 0.35
HTR3A known ✓ P46098 1/20 0.35
SLC6A3 known ✓ Q01959 1/20 0.35
HTR4 known ✓ Q13639 1/20 0.35
HRH1 known ✓ P35367 3/20 0.32
GABRP known ✓ O00591 1/20 0.30
GABRD known ✓ O14764 1/20 0.30
GABRA1 known ✓ P14867 1/20 0.30
GABRB1 known ✓ P18505 1/20 0.30
GABRG2 known ✓ P18507 1/20 0.30
GABRB3 known ✓ P28472 1/20 0.30
GABRA5 known ✓ P31644 1/20 0.30
GABRA3 known ✓ P34903 1/20 0.30
GABRA2 known ✓ P47869 1/20 0.30
GABRB2 known ✓ P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2384781 0.98 SLC6A4 (0.36) SLC6A4SLC6A2HTR2AHTR2CHTR7
Bromide SCHEMBL11401473 0.95 SLC6A4 (0.35) SLC6A4SLC6A2HTR2AHTR2CHTR7
SCHEMBL27307776 0.90 NPC1 (0.34) SLC6A4SLC6A2HTR2AHTR2CHTR7
Hydrochloric Acid SCHEMBL23249955 0.88 MEN1 (0.42) SLC6A4SLC6A2HTR2AHTR2CHTR7
Hydrochloric Acid SCHEMBL848878 0.88 MEN1 (0.42) SLC6A4SLC6A2HTR2AHTR2CHTR7
Hydrochloric Acid SCHEMBL25375183 0.87 CHRM1 (0.39) SLC6A4SLC6A2SLC6A3GABRA1GABRA5
SCHEMBL23267863 0.85 MEN1 (0.44) SLC6A4SLC6A2HTR2AHTR2CHTR7
SCHEMBL21458667 0.85 MEN1 (0.44) SLC6A4SLC6A2HTR2AHTR2CHTR7
SCHEMBL880061 0.85 MEN1 (0.44) SLC6A4SLC6A2HTR2AHTR2CHTR7
SCHEMBL2146710 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636385-B2 Selective ligands for tau aggregates SENTONIX, INC. (US) 2026-05-26 US disclosed
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2025-05-27 US disclosed
US-11584757-B2 MK2 inhibitors and uses thereof CELGENE CAR LLC (BM) 2023-02-21 US disclosed
CN-115397821-A Bifunctional molecules containing an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety 阿尔维纳斯运营股份有限公司 2022-11-25 CN disclosed
US-20220323457-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2022-10-13 US disclosed
EP-4045496-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY Arvinas Operations, Inc. (US) 2022-08-24 EP disclosed
EP-3912981-A1 MK2 INHIBITORS AND USES THEREOF CELGENE CAR LLC (BM) 2021-11-24 EP disclosed
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES CBD SOLUTIONS AB (SE) 2021-05-13 US disclosed
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 WO disclosed
EP-3193611-B1 MK2 INHIBITORS AND USES THEREOF CELGENE CAR LLC (BM) 2021-03-24 EP disclosed
US-9487517-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-08 US disclosed
US-9458175-B2 MK2 inhibitors and uses thereof CELGENE AVILOMICS RESEARCH, INC. (US) 2016-10-04 US disclosed
WO-2016044463-A2 MK2 INHIBITORS AND USES THEREOF CELGENE AVILOMICS RESEARCH, INC. (US) 2016-03-24 WO disclosed
US-20160075720-A1 MK2 INHIBITORS AND USES THEREOF BRISTOL-MYERS SQUIBB COMPANY 2016-03-17 US disclosed
US-20160016956-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-01-21 US disclosed
EP-2433940-B9 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2015-10-28 EP disclosed
US-9169254-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-27 US disclosed
EP-2433940-B1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2014-09-24 EP disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US disclosed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210138092-A1 SELECTIVE LIGANDS FOR TAU AGGREGATES MAPT, PSEN1, PSEN2 SLC6A4 1738/4885SLC6A2 1124/4885HTR2A 3439/4885
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE WNK3, REN, SGK3 SLC6A4 165/4885SLC6A2 996/4885HTR2A 2283/4885
US-12636385-B2 Selective ligands for tau aggregates MAPT, PSEN2, PSEN1 SLC6A4 1421/4885SLC6A2 369/4885HTR2A 1551/4885
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use BCL6, BCL6B, BCL3 SLC6A4 4580/4885SLC6A2 4565/4885HTR2A 3287/4885
US-20220323457-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE BCL6, BCL6B, BCL3 SLC6A4 4580/4885SLC6A2 4565/4885HTR2A 3287/4885
US-20160075720-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, DUSP2, MKNK1 SLC6A4 4729/4885SLC6A2 4014/4885HTR2A 1870/4885
US-11584757-B2 MK2 inhibitors and uses thereof MKNK2, DUSP2, MKNK1 SLC6A4 4729/4885SLC6A2 4014/4885HTR2A 1870/4885
US-20160016956-A1 SPIROIMIDAZOLONE DERIVATIVE WNK3, REN, SGK3 SLC6A4 165/4885SLC6A2 996/4885HTR2A 2283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.