Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.44 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.34 |
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 0.32 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29405454 | 1.00 | FYN (0.48) | FYNCA1CA2CA12CA7 | |
| SCHEMBL29406232 | 0.98 | FYN (0.50) | FYNCA1CA2CA12CA7 | |
| SCHEMBL614525 | 0.98 | FYN (0.50) | FYNCA1CA2CA12CA7 | |
| SCHEMBL15630255 | 0.88 | FYN (0.42) | FYNCA1CA2CA12CA7 | |
| SCHEMBL22504662 | 0.84 | MAPT (0.58) | MAPTNFKB1THPOHIF1AHSD17B10 | |
| SCHEMBL13072957 | 0.79 | FYN (0.38) | FYNDRD3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL20443999 | 0.74 | FYN (0.33) | FYNDRD3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL17513822 | 0.74 | FYN (0.33) | FYNMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL17949696 | 0.74 | FYN (0.38) | FYNMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL29653964 | 0.74 | FYN (0.38) | FYNMAPTHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116239474-A | Preparation method of indacaterol intermediate 5, 6-diethyl-2, 3-dihydro-1H-indene-2-amine hydrochloride | 石家庄手性化学有限公司 | 2023-06-09 | — | — | CN | claimed |
| CN-115925623-A | Small molecule inhibitor and preparation method and application thereof | 中国药科大学 | 2023-04-07 | — | — | CN | claimed |
| CN-115636784-A | LYW-1 derivative and preparation method and application thereof | 中国药科大学 | 2023-01-24 | — | — | CN | claimed |
| CN-115251078-A | Faint scent type insecticide and preparation method thereof | 安徽朗宜百草生物工程有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-114698642-A | Fragrant insecticide and preparation method thereof | 安徽朗宜百草生物工程有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-110183330-B | Preparation method of 5, 6-diethyl-2, 3-dihydro-1H-indene-2-amine hydrochloride | 安徽华邦药业有限公司 | 2022-05-27 | — | — | CN | claimed |
| EP-1487781-B8 | PROCESS FOR PREPARING 2-AMINOINDAN DERIVATIVES | NOVARTIS AG (CH) | 2009-06-03 | — | — | EP | claimed |
| US-6933410-B2 | Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine | NOVARTIS AG (CH) | 2005-08-23 | — | — | US | claimed |
| EP-1487781-A2 | PROCESS FOR PREPARING 2-AMINOINDAN DERIVATIVES | Novartis AG (CH) | 2004-12-22 | — | — | EP | claimed |
| US-20030187301-A1 | Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine | NOVARTIS AG (CH) | 2003-10-02 | — | — | US | claimed |
| WO-2003076387-A2 | PROCESS FOR PREPARING 2-AMINOINDAN DERIVATIVES | NOVARTIS AG (CH) | 2003-09-18 | — | — | WO | claimed |
| CN-116239474-A | Preparation method of indacaterol intermediate 5, 6-diethyl-2, 3-dihydro-1H-indene-2-amine hydrochloride | 石家庄手性化学有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-116239474-A | Preparation method of indacaterol intermediate 5, 6-diethyl-2, 3-dihydro-1H-indene-2-amine hydrochloride | 石家庄手性化学有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-116239474-A | Preparation method of indacaterol intermediate 5, 6-diethyl-2, 3-dihydro-1H-indene-2-amine hydrochloride | 石家庄手性化学有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-115925623-A | Small molecule inhibitor and preparation method and application thereof | 中国药科大学 | 2023-04-07 | — | — | CN | disclosed |
| WO-2004096800-A2 | QUINUCLIDINE DERIVATIVES BINDING TO MUCARINIC M3 RECEPTORS | NOVARTIS AG (CH) | 2004-11-11 | — | — | WO | disclosed |
| US-6800643-B2 | CORTICOSTEROID AND AN INDANYL-QUINOLINONE COMPOUND | NOVARTIS AG (CH) | 2004-10-05 | — | — | US | disclosed |
| US-20040038951-A1 | Organic compounds | NOVARTIS AG (CH) | 2004-02-26 | — | — | US | disclosed |
| US-20030187301-A1 | Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine | NOVARTIS AG (CH) | 2003-10-02 | — | — | US | disclosed |
| WO-2003076387-A2 | PROCESS FOR PREPARING 2-AMINOINDAN DERIVATIVES | NOVARTIS AG (CH) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038951-A1 | Organic compounds | CYP11B2, NR3C2, CYP11B1 | CA2 618/4885DRD2 3211/4885DRD3 2591/4885 |
| US-20030187301-A1 | Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine | NAT1, AADAC, IDH3A | CA2 1591/4885DRD2 80/4885DRD3 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.