Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245633 | 0.98 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL2754173 | 0.81 | — | — | |
| SCHEMBL8215008 | 0.81 | ALDH1A1 (0.45) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| Guanidine SCHEMBL28281782 | 0.79 | TSHR (0.52) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL37468 | 0.79 | — | — | |
| SCHEMBL5969554 | 0.78 | TSHR (0.46) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL1506053 | 0.78 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL30688875 | 0.77 | ALDH1A1 (0.45) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL10658213 | 0.77 | ALDH1A1 (0.56) | TSHRALDH1A1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL7996738 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102241794-B | Preparation method of reversible agglomeration and re-dispersion latex based on amidine compound | UNIV ZHEJIANG | 2012-12-19 | — | — | CN | claimed |
| CN-102492106-A | Large molecular emulsifier with switchable surface activity and application thereof to preparation of rubber latex | UNIV ZHEJIANG | 2012-06-13 | — | — | CN | claimed |
| CN-102241794-A | Preparation method of reversible agglomeration and re-dispersion latex based on amidine compound | UNIV ZHEJIANG | 2011-11-16 | — | — | CN | claimed |
| CN-101941675-A | Nanoparticles and preparation method thereof | XU WANG | 2011-01-12 | — | — | CN | claimed |
| US-11572341-B2 | Biguanide compound and use thereof | IMMUNOMET THERAPEUTICS INC. (US) | 2023-02-07 | — | — | US | disclosed |
| US-20200277255-A1 | BIGUANIDE COMPOUND AND USE THEREOF | IMMUNOMET THERAPEUTICS INC. | 2020-09-03 | — | — | US | disclosed |
| US-9624317-B2 | Amphiphilic macromolecular emulsifier with switchable surface activity and use thereof in preparation of polymer latex | ZHEJIANG UNIVERSITY (CN) | 2017-04-18 | — | — | US | disclosed |
| US-20140316049-A1 | AMPHIPHILIC MACROMOLECULAR EMULSIFIER WITH SWITCHABLE SURFACE ACTIVITY AND USE THEREOF IN PREPARATION OF POLYMER LATEX | ZHEJIANG UNIVERSITY (CN) | 2014-10-23 | — | — | US | disclosed |
| CN-102241794-B | Preparation method of reversible agglomeration and re-dispersion latex based on amidine compound | UNIV ZHEJIANG | 2012-12-19 | — | — | CN | disclosed |
| CN-102492106-A | Large molecular emulsifier with switchable surface activity and application thereof to preparation of rubber latex | UNIV ZHEJIANG | 2012-06-13 | — | — | CN | disclosed |
| CN-102241794-A | Preparation method of reversible agglomeration and re-dispersion latex based on amidine compound | UNIV ZHEJIANG | 2011-11-16 | — | — | CN | disclosed |
| CN-101941675-A | Nanoparticles and preparation method thereof | XU WANG | 2011-01-12 | — | — | CN | disclosed |
| CN-1493601-A | Aqueous emulsion type fluorine containing water repellent oil repellent agent and its preparation method | 华东理工大学 | 2004-05-05 | — | — | CN | disclosed |
| US-5665843-A | Allylbiguanide polymer and method of producing same | DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 1997-09-09 | — | — | US | disclosed |
| EP-0411153-B1 | TRIAZINE DERIVATIVE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT | IDEMITSU KOSAN CO (JP) | 1996-09-11 | — | — | EP | disclosed |
| US-5403815-A | Combats weeds without casuing phytotoxicity to corn, barley, wheat or grains | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1995-04-04 | — | — | US | disclosed |
| EP-0620220-A2 | A triazine derivatives as herbicides | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-10-19 | — | — | EP | disclosed |
| US-5290754-A | Useful against weeds in rice crops | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0411153-A1 | TRIAZINE DERIVATIVE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1991-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572341-B2 | Biguanide compound and use thereof | MKI67, GCG, GCKR | GAA 788/4885TSHR 2521/4885ALDH1A1 1098/4885 |
| US-20200277255-A1 | BIGUANIDE COMPOUND AND USE THEREOF | MKI67, GCG, GCKR | GAA 788/4885TSHR 2521/4885ALDH1A1 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.