Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tyrosine Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.61 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.61 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.52 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.49 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 5/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine Methyl Ester SCHEMBL1255128 | 1.00 | ESR1 (0.61) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL945724 | 1.00 | ESR1 (0.61) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL9818526 | 0.98 | ESR1 (0.59) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL1255129 | 0.98 | ESR1 (0.63) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL314923 | 0.98 | ESR1 (0.63) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL313051 | 0.98 | ESR1 (0.63) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL10337296 | 0.97 | ESR1 (0.61) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL28872878 | 0.97 | ESR1 (0.61) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL7389911 | 0.95 | ESR1 (0.59) | ESR1ESR2SLC7A5ALDH1A1MIF | |
| Tyrosine Methyl Ester SCHEMBL22390809 | 0.93 | ESR1 (0.58) | ESR1ESR2SLC7A5ALDH1A1MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 632 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119970736-A | Synthesis method of histone deacetylase 4 small molecule inhibitor and application of inhibitor in vascular endothelial aging resistance | 澳门科技大学 | 2025-05-13 | — | — | CN | claimed |
| CN-119874660-A | Amino acid derivative-rhodamine B conjugate, preparation method thereof and application thereof as fluorescent tracer | 内蒙古农业大学 | 2025-04-25 | — | — | CN | claimed |
| CN-119409588-A | Caffeoyl amino acid methyl ester derivative and preparation method and application thereof | 西北大学 | 2025-02-11 | — | — | CN | claimed |
| WO-2025026273-A1 | DEGRADABLE VALVE STENT, VALVE STENT FOR PULMONARY ARTERIAL VALVE, PULMONARY ARTERIAL VALVE, AND HEART VALVE | 元心科技(深圳)有限公司 | 2025-02-06 | — | — | WO | claimed |
| CN-118290360-A | Synthetic method of organic light response probe HBT-CN based on ESIPT effect, obtained probe and application thereof | 临沂大学 | 2024-07-05 | — | — | CN | claimed |
| CN-118084735-A | Photo-delay synthesis method of O- [2- [ [ tert-butyloxycarbonyl ] amino ] ethyl ] -N- [ fluorenylmethoxycarbonyl ] -L-tyrosine | 吉尔多肽生物制药(大连市)有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-117903078-A | Amide derivative containing 3, 4-dichloro isothiazole, preparation method and application thereof | 南开大学 | 2024-04-19 | — | — | CN | claimed |
| US-11931329-B2 | Compositions and methods for treating anxiety-related disorders | YAMO PHARMACEUTICALS LLC (US) | 2024-03-19 | — | — | US | claimed |
| CN-113563219-B | L-tyrosine derivative and spherical mesoporous silica nanoparticle as well as preparation methods and applications thereof | 沈阳药科大学 | 2023-12-26 | — | — | CN | claimed |
| US-11786496-B2 | Composition and methods for treating intestinal hyperpermeability | YAMO PHARMACEUTICALS LLC (US) | 2023-10-17 | — | — | US | claimed |
| CN-100422147-C | Method of preparing compound of 0-substituted sulphonyl propylhomoserin class | TIANHENG ACADEMY OF MEDICATION (CN) | 2008-10-01 | — | — | CN | claimed |
| EP-1926466-A2 | STABLE EMULSION SYSTEMS WITH HIGH SALT TOLERANCE | COMBE INCORPORATED (US) | 2008-06-04 | — | — | EP | claimed |
| WO-2007040598-A2 | STABLE EMULSION SYSTEMS WITH HIGH SALT TOLERANCE | COMBE INCORPORATED (US) | 2007-04-12 | — | — | WO | claimed |
| CN-1943791-A | Liver target high molecule magnetic resonance image-forming contrast medium and its synthesizing method and application | UNIV HUADONG (CN) | 2007-04-11 | — | — | CN | claimed |
| US-20070065390-A1 | Stable emulsion systems with high salt tolerance | RECKITT BENCKISER LLC | 2007-03-22 | — | — | US | claimed |
| EP-1032262-A4 | METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS | NONOMURA ARTHUR M (US) | 2005-03-23 | — | — | EP | claimed |
| CN-1415606-A | Method of preparing compound of 0-substituted sulphonyl propylhomoserin class | TIANHENG ACADEMY OF MEDICATION (CN) | 2003-05-07 | — | — | CN | claimed |
| EP-1032262-A1 | METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS | NONOMURA, Arthur M. (US) | 2000-09-06 | — | — | EP | claimed |
| US-6020288-A | PLANT GROWTH AGENT | NONOMURA ARTHUR M (US) | 2000-02-01 | — | — | US | claimed |
| WO-1999012417-A1 | METHODS AND COMPOSITIONS FOR ENHANCING CYTOCHROME P450 IN PLANTS | NONOMURA ARTHUR M (US) | 1999-03-18 | — | — | WO | claimed |