Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.38 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178804 | 0.82 | IDO1 (0.53) | IDO1HSPA5AKR1B1KEAP1TSHR | |
| SCHEMBL5322380 | 0.81 | IDO1 (0.52) | IDO1HSPA5AKR1B1KEAP1TSHR | |
| SCHEMBL12732386 | 0.79 | IDO1 (0.50) | IDO1HSPA5AKR1B1KEAP1TSHR | |
| SCHEMBL5322384 | 0.79 | IDO1 (0.50) | IDO1HSPA5AKR1B1KEAP1TSHR | |
| SCHEMBL28208046 | 0.77 | TSHR (0.49) | IDO1HSPA5AKR1B1TSHR | |
| SCHEMBL21446960 | 0.77 | TSHR (0.55) | IDO1AKR1B1KEAP1TSHRMPO | |
| SCHEMBL30705776 | 0.77 | TSHR (0.55) | IDO1AKR1B1KEAP1TSHRMPO | |
| SCHEMBL9494548 | 0.77 | IDO1 (0.47) | IDO1HSPA5AKR1B1KEAP1TSHR | |
| SCHEMBL28727309 | 0.74 | ALDH1A1 (0.48) | IDO1HSPA5AKR1B1TSHR | |
| SCHEMBL8118478 | 0.74 | TSHR (0.48) | IDO1HSPA5AKR1B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120171156-A1 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LTD. (GB) | 2012-07-05 | — | — | US | claimed |
| EP-2442873-A2 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | Hds Limited (GB) | 2012-04-25 | — | — | EP | claimed |
| WO-2010146142-A9 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2011-06-16 | — | — | WO | claimed |
| WO-2010146142-A2 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| EP-2968157-B1 | FINE DRY PARTICULATE RETINOID ACTIVE AGENT COMPOSITIONS AND TOPICAL FORMULATIONS INCLUDING THE SAME | LABORATORY SKIN CARE INC (US) | 2023-11-08 | — | — | EP | disclosed |
| US-11753379-B2 | Process for forming 2-hydroxypyridine-1-oxide or derivatives thereof | CLARIANT INTERNATIONAL LTD (CH) | 2023-09-12 | — | — | US | disclosed |
| US-20220202687-A1 | Use Of A Bio-Based Polymer In A Cosmetic, Dermatological Or Pharmaceutical Composition | CLARIANT INTERNATIONAL LTD. (CH) | 2022-06-30 | — | — | US | disclosed |
| EP-4008406-A1 | COSMETIC COMPOSITION BASED ON ACROYL TAURATE TYPE POLYMERS | Clariant International Ltd (CH) | 2022-06-08 | — | — | EP | disclosed |
| US-11311473-B2 | Use of a bio-based polymer in a cosmetic, dermatological or pharmaceutical composition | CLARIANT INTERNATIONAL LTD (CH) | 2022-04-26 | — | — | US | disclosed |
| US-20210290514-A1 | An Antimicrobial Combination Composition Comprising Glycerol Derivatives and Bicyclic Compounds | SACHEM EUROPE B.V. (NL) | 2021-09-23 | — | — | US | disclosed |
| US-20210214307-A1 | PROCESS FOR FORMING 2-HYDROXYPYRIDINE-1-OXIDE OR DERIVATIVES THEREOF | CLARIANT INTERNATIONAL LTD. (CH) | 2021-07-15 | — | — | US | disclosed |
| EP-3817712-A1 | AN ANTIMICROBIAL COMBINATION COMPOSITION COMPRISING GLYCEROL DERIVATIVES AND BICYCLIC COMPOUNDS | Clariant International Ltd (CH) | 2021-05-12 | — | — | EP | disclosed |
| US-20110182826-A1 | Composition With A Color To Indicate Coverage | COLGATE-PALMOLIVE COMPANY (US) | 2011-07-28 | — | — | US | disclosed |
| EP-2346476-A1 | COMPOSITION WITH A COLOR MARKER | Colgate-Palmolive Company (US) | 2011-07-27 | — | — | EP | disclosed |
| EP-2346477-A1 | COMPOSITION WITH A COLOR TO INDICATE COVERAGE | Colgate-Palmolive Company (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010146142-A9 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |
| US-20110021397-A1 | Composition With A Color Marker | COLGATE-PALMOLIVE COMPANY | 2011-01-27 | — | — | US | disclosed |
| WO-2010146142-A2 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010056233-A1 | COMPOSITION WITH A COLOR TO INDICATE COVERAGE | COLGATE-PALMOLIVE COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056232-A1 | COMPOSITION WITH A COLOR MARKER | COLGATE PALMOLIVE COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11311473-B2 | Use of a bio-based polymer in a cosmetic, dermatological or pharmaceutical composition | CUTA, COL1A1, PGM2 | CA12 607/4885CA2 2979/4885IDO1 1778/4885 |
| US-20210290514-A1 | An Antimicrobial Combination Composition Comprising Glycerol Derivatives and Bicyclic Compounds | GK, MGLL, UGCG | CA12 4680/4885CA2 4452/4885IDO1 836/4885 |
| US-20210214307-A1 | PROCESS FOR FORMING 2-HYDROXYPYRIDINE-1-OXIDE OR DERIVATIVES THEREOF | HMOX2, HMOX1, HPD | CA12 2845/4885CA2 932/4885IDO1 73/4885 |
| US-11753379-B2 | Process for forming 2-hydroxypyridine-1-oxide or derivatives thereof | HMOX2, HMOX1, HPD | CA12 2845/4885CA2 932/4885IDO1 73/4885 |
| US-20220202687-A1 | Use Of A Bio-Based Polymer In A Cosmetic, Dermatological Or Pharmaceutical Composition | CUTA, COL1A1, PGM2 | CA12 607/4885CA2 2979/4885IDO1 1778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.