Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 known ✓ | P09884 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL351072 | 1.00 | TSHR (0.58) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL3613959 | 1.00 | TSHR (0.58) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL164305 | 1.00 | TSHR (0.58) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL120844 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL44285 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL43894 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL1266800 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL44179 | 0.96 | TSHR (0.64) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL328732 | 0.93 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL988664 | 0.86 | SPHK2 (0.35) | TSHRLMNAALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7871776-B2 | Compositions and methods for enhancing the identification of prior protein PrPSc | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-01-18 | — | — | US | disclosed |
| US-20100233763-A1 | DUAL-SIDED THERMAL CYCLER | APPLIED BIOSYSTEMS, LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-20090325277-A1 | Thermal Device, System, and Method, for Fluid Processing Device | APPLIED BIOSYSTEMS, LLC (US) | 2009-12-31 | — | — | US | disclosed |
| US-7585663-B2 | Thermal device, system, and method, for fluid processing device | APPLIED BIOSYSTEMS, LLC (US) | 2009-09-08 | — | — | US | disclosed |
| US-7491363-B2 | Fluid processing device | APPLIED BIOSYSTEMS, LLC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-20080261316-A1 | Compositions and Methods For Enhancing the Identification of Prior Protein Prpsc | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-10-23 | — | — | US | disclosed |
| US-7407760-B2 | Compositions and methods for enhancing the identification of prion protein PRPSc | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2008-08-05 | — | — | US | disclosed |
| WO-2007082173-A2 | COMPOSITIONS AND METHODS FOR ENHANCING THE IDENTIFICATION OF PRION PROTEIN PRPSC | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2007-07-19 | — | — | WO | disclosed |
| EP-1789781-A2 | THERMAL DEVICE, SYSTEM, AND METHOD, FOR FLUID PROCESSING DEVICE | Applera Corporation (US) | 2007-05-30 | — | — | EP | disclosed |
| US-20060127888-A1 | Compositions and methods for enhancing the identification of prion protein PRPsc | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-06-15 | — | — | US | disclosed |
| WO-2006025929-A2 | THERMAL DEVICE, SYSTEM, AND METHOD, FOR FLUID PROCESSING DEVICE | APPLERA CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
| US-20060046304-A1 | Thermal device, system, and method, for fluid processing device | APPLERA CORPORATION (US) | 2006-03-02 | — | — | US | disclosed |
| WO-2006019500-A2 | FLUID PROCESSING DEVICE | APPLERA CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060013741-A1 | Fluid processing device | APPLERA CORPORATION (US) | 2006-01-19 | — | — | US | disclosed |
| EP-1252172-A2 | COMPOUND COMPRISING A PEPTIDE MOIETY AND AN ORGANO-SILANE MOIETY | VBC-Genomics Bioscience Research GmbH (AT) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001046213-A2 | COMPOUND COMPRISING A PEPTIDE MOIETY AND AN ORGANO-SILANE MOIETY. | VBC-GENOMICS BIOSCIENCE RESEARCH GMBH (AT) | 2001-06-28 | — | — | WO | disclosed |
| US-6066319-A | Drug delivery using terminal complement components | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-05-23 | — | — | US | disclosed |
| US-5053388-A | Coating corneal incision with protein crosslinking compound, applying extra cellular matrix material, both with carriers | CHIRON OPHTHALMICS, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| WO-1989004172-A1 | WOUND HEALING COMPOSITION AND METHOD | CHIRON OPHTHALMICS INC. (US) | 1989-05-18 | — | — | WO | disclosed |