Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Buformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B known ✓ | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 known ✓ | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A known ✓ | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B known ✓ | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C known ✓ | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 2/20 | 0.34 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buformin SCHEMBL11130179 | 0.89 | GRIN2D (0.39) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL15669256 | 0.87 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL6018 | 0.87 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL3644254 | 0.87 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL749659 | 0.87 | GRIN2D (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL3455307 | 0.85 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL4235633 | 0.85 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL22436277 | 0.85 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL5483046 | 0.85 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Buformin SCHEMBL1048416 | 0.85 | GRIN2D (0.41) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2373 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853254-B1 | A composition for lightening skin and/or hair | SYMRISE AG (DE) | 2017-11-08 | — | — | EP | claimed |
| EP-2320869-A1 | SURFACTANT-FREE EMULSIONS WITH ANTI-AGING EFFECT, PRODUCTION THEREOF AND USE OF SAME | HC Berlin Pharma Ag (DE) | 2011-05-18 | — | — | EP | claimed |
| WO-2010012686-A1 | SURFACTANT-FREE EMULSIONS WITH ANTI-AGING EFFECT, PRODUCTION THEREOF AND USE OF SAME | HC BERLIN PHARMA AG (DE) | 2010-02-04 | — | — | WO | claimed |
| EP-1455744-A2 | COSMETIC AND/OR DERMATOLOGICAL ACTIVE INGREDIENT COMBINATION | Beiersdorf AG (DE) | 2004-09-15 | — | — | EP | claimed |
| WO-2003032941-A2 | COSMETIC AND/OR DERMATOLOGICAL ACTIVE INGREDIENT COMBINATION | BEIERSDORF AG (DE) | 2003-04-24 | — | — | WO | claimed |
| EP-3801448-B1 | WAX DISPERSIONS WITH CONDITIONING PROPERTIES | BASF SE (DE) | 2024-07-10 | — | — | EP | disclosed |
| EP-4282853-A1 | PROCESS FOR THE PREPARATION OF MESACONIC ACID ESTERS | Symrise AG (DE) | 2023-11-29 | — | — | EP | disclosed |
| EP-2958546-B1 | MEDICAMENT FOR TREATING THE SKIN AGEING CAUSED BY UV RADIATION | SYMRISE AG (DE) | 2023-11-22 | — | — | EP | disclosed |
| WO-2023186910-A1 | PHOTOPROTECTIVE COMPOSITION FOR PROTECTING THE SKIN FROM VISIBLE LIGHT | STADA ARZNEIMITTEL AG (DE) | 2023-10-05 | — | — | WO | disclosed |
| EP-4252737-A1 | SUNSCREEN COMPOSITION FOR PROTECTING THE SKIN FROM VISIBLE LIGHT | STADA ARZNEIMITTEL AG (DE) | 2023-10-04 | — | — | EP | disclosed |
| EP-4247791-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2023-09-27 | — | — | EP | disclosed |
| EP-3536383-B1 | CLEANING AND CARE PREPARATIONS COMPRISING A POLYOXYALKYLENE CARBOXYLATE | PERFECT IDEAS GMBH (CH) | 2023-09-27 | — | — | EP | disclosed |
| EP-0701814-A2 | Cosmetic or dermatologic composition containing hydrophobised inorganic pigment to maintain the amount of the skin urocanic acid | Beiersdorf Aktiengesellschaft (DE) | 1996-03-20 | — | — | EP | disclosed |
| WO-1996002223-A1 | EMULSIFIER-FREE, FINELY DISPERSED COSMETIC OR DERMATOLOGICAL OIL-IN-WATER TYPE PREPARATIONS | BEIERSDORF AG (DE) | 1996-02-01 | — | — | WO | disclosed |
| EP-0691126-A1 | Cosmetic or dermatological compositions containing alpha hydroxy carboxylic acids and/or keto carboxylic acids and inorganic pigments | Beiersdorf Aktiengesellschaft (DE) | 1996-01-10 | — | — | EP | disclosed |
| EP-0691127-A1 | Shower oil | Beiersdorf Aktiengesellschaft (DE) | 1996-01-10 | — | — | EP | disclosed |
| WO-1995017155-A1 | W/O/W EMULSIONS | BEIERSDORF AG (DE) | 1995-06-29 | — | — | WO | disclosed |
| WO-1995005852-A1 | AGENT AGAINST SENSITIVE, HYPERREACTIVE AND HYPOACTIVE STATES OF THE SKIN, FORMS OF ACNE, ATOPIC DERMATITIDES, PSORIASIS, PRURIGO, PHOTODERMATOSES, ICHTHYOSIS AND VIRAL INFECTIONS | BEIERSDORF AG (DE) | 1995-03-02 | — | — | WO | disclosed |
| EP-0120404-B1 | PROCESS FOR PREPARING BENZAL CHLORIDES | BAYER AG (DE) | 1986-02-19 | — | — | EP | disclosed |
| EP-0120404-A1 | Process for preparing benzal chlorides | BAYER AG (DE) | 1984-10-03 | — | — | EP | disclosed |