Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.30 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.30 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28350123 | 0.93 | ALDH1A1 (0.38) | ALDH1A1TSHRCA1CA2CA9 | |
| SCHEMBL376165 | 0.89 | ALDH1A1 (0.40) | ALDH1A1TSHRCA1CA2CA9 | |
| Water SCHEMBL8463966 | 0.86 | ALDH1A1 (0.38) | ALDH1A1TSHRCA1CA2CA9 | |
| SCHEMBL28124861 | 0.86 | ALDH1A1 (0.38) | ALDH1A1TSHRCA1CA2CA9 | |
| Boric Acid SCHEMBL29086148 | 0.78 | CA4 (0.43) | ALDH1A1TSHRCA1CA2CA9 | |
| SCHEMBL28774857 | 0.78 | TSHR (0.35) | ALDH1A1TSHRLMNA | |
| Toluene SCHEMBL28585408 | 0.75 | ACHE (0.65) | TSHRCA1CA2CA9TDP1 | |
| SCHEMBL9742323 | 0.73 | SLC6A2 (0.50) | ALDH1A1TSHRTDP1LMNA | |
| SCHEMBL31553488 | 0.73 | APP (0.37) | — | |
| SCHEMBL1030998 | 0.73 | ACHE (0.53) | ALDH1A1TSHRCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257765-A1 | Cold flow improver and method of use thereof | PETROLITE CORPORATION (US) | 1988-03-02 | — | — | EP | disclosed |
| US-4708993-A | OLIGOMERS OF ESTER-CONTAINING HALOPOLYALKYENES AS OIL OR FUEL ADDITIVES | PETROLITE CORPORATION (US) | 1987-11-24 | — | — | US | disclosed |
| US-4617025-A | POUR POINT DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1986-10-14 | — | — | US | disclosed |
| US-4568359-A | FUEL OIL POUR DEPRESSANTS | PETROLITE CORPORATION (US) | 1986-02-04 | — | — | US | disclosed |
| US-4568726-A | REACTING HALOGENATED POLYALKENE WITH CARBOXYLIC ACID OR SALT; POUR DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1986-02-04 | — | — | US | disclosed |
| US-4553980-A | POUR DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |
| US-4554327-A | ESTERIFIED HALOGENATED POLYOLEFIN | PETROLITE CORPORATION (US) | 1985-11-19 | — | — | US | disclosed |
| US-4544712-A | POUR DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1985-10-01 | — | — | US | disclosed |
| US-4541839-A | POUR POINT DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1985-09-17 | — | — | US | disclosed |
| US-4536551-A | FREE OF CROSSLINKING; POUR DEPRESSSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1985-08-20 | — | — | US | disclosed |
| US-4536191-A | FOUR POINT DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1985-08-20 | — | — | US | disclosed |
| US-4471098-A | REACTION OF HALOGENATED POLYALKENE WITH CARBOXY ACID SALT, REPLACES HALO GROUPS WITH ESTER GROUPS, POUR DEPRESSANTS FOR FUEL OILS | PETROLITE CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |