Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Y-27632. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 8/20 | 1.00 |
| ▸ | ROCK1 known ✓ | Q13464 | 8/20 | 1.00 |
| ▸ | PRKCE known ✓ | Q02156 | 1/20 | 1.00 |
| ▸ | PRKD3 known ✓ | O94806 | 2/20 | 0.97 |
| ▸ | PRKCQ known ✓ | Q04759 | 2/20 | 0.97 |
| ▸ | PRKCD known ✓ | Q05655 | 2/20 | 0.97 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.97 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.55 |
| ▸ | PRKCG known ✓ | P05129 | 1/20 | 0.54 |
| ▸ | PRKCI known ✓ | P41743 | 1/20 | 0.54 |
| ▸ | ACVR1 known ✓ | Q04771 | 1/20 | 0.54 |
| ▸ | ALK known ✓ | Q9UM73 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.97 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.97 |
| ▸ | CDK1 | P06493 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Y-27632 SCHEMBL819701 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL819702 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL1554110 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL29129858 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL30686996 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL2834049 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL364637 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL21954489 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL4296190 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL364638 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 351 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843845-B1 | INHIBITION OF PROTEIN KINASES TO TREAT FRIEDREICH ATAXIA | UNIV MASSACHUSETTS (US) | 2026-03-11 | — | — | EP | claimed |
| US-20250382575-A1 | PROCESS FOR OBTAINING FUNCTIONAL LYMPHOCYTES CELLS | NANTES UNIVERSITÉ (FR) | 2025-12-18 | — | — | US | claimed |
| EP-4540371-A1 | PROCESS FOR OBTAINING FUNCTIONAL LYMPHOCYTES CELLS | Nantes Université (FR) | 2025-04-23 | — | — | EP | claimed |
| WO-2023242398-A1 | PROCESS FOR OBTAINING FUNCTIONAL LYMPHOCYTES CELLS | NANTES UNIVERSITÉ (FR) | 2023-12-21 | — | — | WO | claimed |
| CN-116376696-A | 3D taste organoid device and method based on microfluidic chip culture | 西安交通大学 | 2023-07-04 | — | — | CN | claimed |
| US-11180733-B2 | Method of generating mesenchymal stem cells and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2021-11-23 | — | — | US | claimed |
| CN-105339489-B | Method for differentiating pluripotent stem cells into pluripotent kidney precursors | 豪夫迈·罗氏有限公司 | 2021-09-03 | — | — | CN | claimed |
| US-20190322987-A1 | METHOD OF GENERATING MESENCHYMAL STEM CELLS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-10-24 | — | — | US | claimed |
| US-10323229-B1 | Three-dimensional human stem cell-derived cortical spheroid model | The Florida State University Research Foundation, Inc. (US) | 2019-06-18 | — | — | US | claimed |
| US-10138468-B2 | Method for differentiation of pluripotent stem cells into multi-competent renal precursors | HOFFMANN-LA ROCHE INC. (US) | 2018-11-27 | — | — | US | claimed |
| US-9006394-B2 | Peptide-presenting surfaces for long-term culture of pluripotent cells | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-04-14 | — | — | US | claimed |
| US-20140315305-A1 | METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL | KEIO UNIVERSITY (JP) | 2014-10-23 | — | — | US | claimed |
| US-20140287505-A1 | PEPTIDE-PRESENTING SURFACES FOR LONG-TERM CULTURE OF PLURIPOTENT CELLS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2014-09-25 | — | — | US | claimed |
| EP-2765188-A1 | METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL | Keio University (JP) | 2014-08-13 | — | — | EP | claimed |
| US-8648170-B2 | Peptide-presenting surfaces for long-term culture of pluripotent cells | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-02-11 | — | — | US | claimed |
| US-20130210060-A1 | METHOD OF PRODUCING PANCREATIC HORMONE-PRODUCING CELLS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-08-15 | — | — | US | claimed |
| EP-2604685-A1 | METHOD OF PRODUCING PANCREATIC HORMONE-PRODUCING CELLS | Takeda Pharmaceutical Company Limited (JP) | 2013-06-19 | — | — | EP | claimed |
| EP-2342319-A2 | PEPTIDE-PRESENTING SURFACES FOR LONG-TERM CULTURE OF PLURIPOTENT CELLS | Wisconsin Alumni Research Foundation (US) | 2011-07-13 | — | — | EP | claimed |
| US-20100087004-A1 | PEPTIDE-PRESENTING SURFACES FOR LONG-TERM CULTURE OF PLURIPOTENT CELLS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-04-08 | — | — | US | claimed |
| WO-2010033925-A2 | PEPTIDE-PRESENTING SURFACES FOR LONG-TERM CULTURE OF PLURIPOTENT CELLS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-03-25 | — | — | WO | claimed |