Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Y-27632. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 8/20 | 1.00 |
| ▸ | ROCK1 known ✓ | Q13464 | 8/20 | 1.00 |
| ▸ | PRKCE known ✓ | Q02156 | 1/20 | 1.00 |
| ▸ | PRKD3 known ✓ | O94806 | 2/20 | 0.97 |
| ▸ | PRKCQ known ✓ | Q04759 | 2/20 | 0.97 |
| ▸ | PRKCD known ✓ | Q05655 | 2/20 | 0.97 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.97 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.55 |
| ▸ | PRKCG known ✓ | P05129 | 1/20 | 0.54 |
| ▸ | PRKCI known ✓ | P41743 | 1/20 | 0.54 |
| ▸ | ACVR1 known ✓ | Q04771 | 1/20 | 0.54 |
| ▸ | ALK known ✓ | Q9UM73 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.97 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.97 |
| ▸ | CDK1 | P06493 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Y-27632 SCHEMBL819701 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL1554110 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL29129858 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL30686996 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL1165652 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL2834049 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL364637 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL21954489 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL4296190 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 | |
| Y-27632 SCHEMBL364638 | 0.99 | ROCK2 (0.97) | ROCK2ROCK1PKN2TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 518 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025224460-A1 | METHODS FOR INDUCING NATURAL KILLER CELL DIFFERENTIATION | PLASTICELL LTD (GB) | 2025-10-30 | — | — | WO | claimed |
| EP-4580644-A1 | ADVANCED ALVEOLAR EPITHELIAL ORGANOIDS | Children's Hospital Medical Center (US) | 2025-07-09 | — | — | EP | claimed |
| US-20250206845-A1 | PHARMACEUTICAL COMPOSITION INCLUDING RHO-KINASE INHIBITOR FOR PREVENTION OR TREATMENT OF CUTANEOUS FIBROTIC DISORDERS SUCH AS KELOID, ETC. AND USE THEREOF | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2025-06-26 | — | — | US | claimed |
| WO-2025104248-A1 | METHOD OF PRODUCING AN IMMUNE CELL DEVOID OF ENDOGENOUS EFFECTOR FUNCTIONS FROM PLURIPOTENT STEM CELLS | REPAIRON IMMUNO GMBH (DE) | 2025-05-22 | — | — | WO | claimed |
| CN-119876000-A | Oocyte culturing method and application thereof | 青岛农业大学 | 2025-04-25 | — | — | CN | claimed |
| CN-119709402-A | Microfluidic chip for dynamic culture of nasal epithelial organoids and culture method thereof | 深圳逸芯生命科学有限公司 | 2025-03-28 | — | — | CN | claimed |
| US-20250090578-A1 | METHOD OF PRODUCING A POPULATION OF IMMUNE CELLS FROM PLURIPOTENT STEM CELLS | REPAIRON IMMUNO GMBH (DE) | 2025-03-20 | — | — | US | claimed |
| CN-119391643-B | Culture medium and method for culturing digestive tract tumor by using three-dimensional tumor tablet technology | 珠海澳大科技研究院 | 2025-03-14 | — | — | CN | claimed |
| CN-119391643-A | Culture medium and method for culturing digestive tract tumor by using three-dimensional tumor tablet technology | 珠海澳大科技研究院 | 2025-02-07 | — | — | CN | claimed |
| CN-118995571-A | Human nasal epithelial organoid expansion medium and extraction and culture method of human primary nasal epithelial cells | 广州逸芯生命科学有限公司 | 2024-11-22 | — | — | CN | claimed |
| CN-114540278-B | Microvascular in-vitro culture method and culture solution | 青岛大学 | 2023-11-21 | — | — | CN | claimed |
| EP-4251177-A2 | ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME | Geneius Biotechnology, Inc. (US) | 2023-10-04 | — | — | EP | claimed |
| WO-2023182856-A1 | PHARMACEUTICAL COMPOSITION INCLUDING RHO-KINASE INHIBITOR FOR PREVENTION OR TREATMENT OF CUTANEOUS FIBROTIC DISORDERS SUCH AS KELOID, ETC. AND USE THEREOF | 서울대학교산학협력단 | 2023-09-28 | — | — | WO | claimed |
| WO-2023096485-A1 | A METHOD FOR GENERATING A HUMAN CORTICAL SPHEROID FROM SELF-RENEWING STEM CELLS CAPABLE OF DIFFERENTIATION | NEURODRUG RESEARCH B.V. (NL) | 2023-06-01 | — | — | WO | claimed |
| WO-2023001833-A1 | METHOD OF PRODUCING A POPULATION OF IMMUNE CELLS FROM PLURIPOTENT STEM CELLS | REPAIRON IMMUNO GMBH (DE) | 2023-01-26 | — | — | WO | claimed |
| WO-2023274338-A1 | CULTURE MEDIUM, METHOD, AND REAGENT KIT FOR RAPIDLY CULTURING TUMOR ORGANOIDS | 丹望医疗科技(上海)有限公司 | 2023-01-05 | — | — | WO | claimed |
| WO-2022115641-A2 | ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME | GENEIUS BIOTECHNOLOGY, INC. (US) | 2022-06-02 | — | — | WO | claimed |
| US-20200140827-A1 | A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS | THE QUEEN'S UNIVERSITY OF BELFAST (GB) | 2020-05-07 | — | — | US | claimed |
| EP-2839831-A1 | Modulators of the unconventional secretory pathway for use in the treatment of Alexander disease | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2015-02-25 | — | — | EP | claimed |
| US-20120010196-A1 | METHODS OF TREATING NEURODEGENERATIVE DISORDERS AND DISEASES | WESTERN UNIVERSITY OF HEALTH SCIENCES | 2012-01-12 | — | — | US | claimed |