Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.31 |
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 known ✓ | P36544 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28176347 | 0.98 | ACHE (0.39) | ACHEAPEX1NPSR1KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL27571208 | 0.98 | ACHE (0.42) | ACHEAPEX1NPSR1KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL21827668 | 0.98 | ACHE (0.42) | ACHEAPEX1KDM4EMAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL61004 | 0.98 | ACHE (0.42) | ACHEAPEX1NPSR1KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL25439071 | 0.96 | ACHE (0.41) | ACHEAPEX1KDM4EMAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL28176346 | 0.96 | ACHE (0.41) | ACHEAPEX1KDM4EMAPK1HIF1A | |
| SCHEMBL25422694 | 0.96 | ACHE (0.43) | ACHEAPEX1NPSR1KDM4EMAPK1 | |
| SCHEMBL33607 | 0.96 | ACHE (0.43) | ACHEAPEX1NPSR1KDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL10531484 | 0.95 | ACHE (0.39) | ACHEAPEX1KDM4EMAPK1HIF1A | |
| Fluoride Ion SCHEMBL8578974 | 0.94 | ACHE (0.42) | ACHEAPEX1KDM4EMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9295648-B2 | Injectable microspheres for dermal augmentation and tissue bulking | BIOSPHERE MEDICAL, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9205053-B2 | Injectable microspheres for dermal augmentation and tissue bulking | BIOSPHERE MEDICAL, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| EP-1656957-B1 | Injectable microspheres for tissue construction | BIOSPHERE MEDICAL INC (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8778333-B2 | Injectable microspheres for tissue construction | BIOSPHERE MEDICAL, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20140065233-A1 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING | BIOSPHERE MEDICAL, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-8658215-B2 | Injectable microspheres for dermal augmentation and tissue bulking | Biospehere Medical, Inc. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130323316-A1 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING | BIOSPHERE MEDICAL, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| EP-2283880-A2 | Injectable microspheres for tissue construction | BIOSPHERE MEDICAL, INC. (US) | 2011-02-16 | — | — | EP | disclosed |
| US-20110033508-A1 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING | BIOSPHERE MEDICAL, INC. (US) | 2011-02-10 | — | — | US | disclosed |
| US-20080118569-A1 | Injectable microspheres for tissue construction | BIOSPHERE MEDICAL, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| US-6660301-B1 | Injectable microspheres for dermal augmentation and tissue bulking | BIOSPHERE MEDICAL, INC. | 2003-12-09 | — | — | US | disclosed |
| US-20030211083-A1 | Injectable microspheres for tissue construction | WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT | 2003-11-13 | — | — | US | disclosed |
| EP-1267955-A2 | INJECTABLE MICROSPHERES FOR TISSUE CONSTRUCTION | BIOSPHERE MEDICAL, INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1267956-A2 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING | BIOSPHERE MEDICAL, INC. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020068089-A1 | Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles | BIOSPHERE MEDICAL, INC. | 2002-06-06 | — | — | US | disclosed |
| US-6335028-B1 | Implantable particles for urinary incontinence | BIOSPHERE MEDICAL, INC. | 2002-01-01 | — | — | US | disclosed |
| WO-2001070291-A2 | INJECTABLE MICROSPHERES FOR DERMAL AUGMENTATION AND TISSUE BULKING | BIOSPHERE MEDICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| WO-2001070290-A2 | INJECTABLE MICROSPHERES FOR TISSUE CONSTRUCTION | BIOSPHERE MEDICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| EP-1059943-A1 | IMPLANTABLE PARTICLES FOR TISSUE BULKING AND THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE, URINARY INCONTINENCE, AND SKIN WRINKLES | Biosepra Medical Inc. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044643-A1 | IMPLANTABLE PARTICLES FOR TISSUE BULKING AND THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE, URINARY INCONTINENCE, AND SKIN WRINKLES | BIOSEPRA MEDICAL INC. (US) | 1999-09-10 | — | — | WO | disclosed |