Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.62 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.53 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.53 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.53 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.53 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.53 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.53 |
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.53 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.51 |
| ▸ | MAOB known ✓ | P27338 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30639583 | 1.00 | TAAR1 (0.62) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL29828865 | 0.98 | TAAR1 (0.65) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL3318610 | 0.98 | TAAR1 (0.65) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| Hydrochloric Acid SCHEMBL20767083 | 0.89 | TAAR1 (0.49) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL2425644 | 0.86 | TAAR1 (0.50) | TAAR1ADRA1AHTR2ACYP1A2HTR1A | |
| SCHEMBL30709158 | 0.85 | TAAR1 (0.68) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL506175 | 0.85 | TAAR1 (0.68) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL8621322 | 0.83 | POLB (0.63) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| Hydrochloric Acid SCHEMBL1437235 | 0.83 | TAAR1 (0.61) | TAAR1ADRA1ABLMPMP22NPSR1 | |
| SCHEMBL9921244 | 0.82 | TAAR1 (0.46) | TAAR1ADRA1ACYP1A2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981672-A | Macrocyclic compounds as CFTR modulators | 爱杜西亚药品有限公司 | 2023-10-31 | — | — | CN | disclosed |
| EP-2809658-B1 | FUNGICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2015-09-30 | — | — | EP | disclosed |
| US-9072301-B2 | Fungicidal pyrimidine compounds | BASF SE (DE) | 2015-07-07 | — | — | US | disclosed |
| US-9055750-B2 | Fungicidal pyrimidine compounds | BASF SE (DE) | 2015-06-16 | — | — | US | disclosed |
| US-9000162-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES LLC (US) | 2015-04-07 | — | — | US | disclosed |
| US-20150024936-A1 | Fungicidal Pyrimidine Compounds | BASF SE (DE) | 2015-01-22 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| US-20140371065-A1 | Fungicidal Pyrimidine Compounds | BASF SE (DE) | 2014-12-18 | — | — | US | disclosed |
| EP-2809658-A1 | FUNGICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2014-12-10 | — | — | EP | disclosed |
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2013-01-17 | — | — | US | disclosed |
| EP-2521452-A1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | Dow AgroSciences LLC (US) | 2012-11-14 | — | — | EP | disclosed |
| US-8268843-B2 | 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2012-09-18 | — | — | US | disclosed |
| EP-2473511-A1 | PTERIDINES AND THEIR USE AS AGROCHEMICALS | Dow AgroSciences LLC (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011085084-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2011-07-14 | — | — | WO | disclosed |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC | 2011-07-07 | — | — | US | disclosed |
| US-20110054173-A1 | PTERIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | US | disclosed |
| WO-2011025505-A1 | PTERIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | WO | disclosed |
| WO-2010025451-A2 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130017950-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | ADRA1A 2140/4885HTR2A 771/4885HTR1A 1158/4885 |
| US-20140371065-A1 | Fungicidal Pyrimidine Compounds | DPM1, DPYD, TYMP | ADRA1A 4411/4885HTR2A 4506/4885HTR1A 3829/4885 |
| US-20150024936-A1 | Fungicidal Pyrimidine Compounds | DPM1, DPYD, TYMP | ADRA1A 4411/4885HTR2A 4506/4885HTR1A 3829/4885 |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DPYD, TYMS, TYMP | ADRA1A 3390/4885HTR2A 1865/4885HTR1A 1715/4885 |
| US-20100056374-A1 | 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS | NQO2, DDT, RAB7A | ADRA1A 2140/4885HTR2A 771/4885HTR1A 1158/4885 |
| US-20110054173-A1 | PTERIDINES AND THEIR USE AS AGROCHEMICALS | PIR, PFAS, PNPO | ADRA1A 3434/4885HTR2A 1423/4885HTR1A 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.