Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oleamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.68 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.68 |
| ▸ | TOP1 known ✓ | P11387 | 1/20 | 0.68 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.68 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.68 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.68 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.68 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.68 |
| ▸ | FAAH | O00519 | 4/20 | 0.96 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.96 |
| ▸ | TP53 | P04637 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.85 |
| ▸ | CNR1 | P21554 | 1/20 | 0.75 |
| ▸ | TERT | O14746 | 3/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8632698 | 1.00 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL29585 | 1.00 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Hydrochloric Acid SCHEMBL7251090 | 1.00 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL3188670 | 1.00 | FAAH (0.96) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL27974384 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL28146913 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL27961302 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL29123821 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL20568155 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A | |
| Oleamide SCHEMBL28228680 | 0.98 | FAAH (0.92) | FAAHSOAT1CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303047-A1 | MEANS FOR LUNG SPECIFIC DELIVERY | SILENCE THERAPEUTICS GMBH (DE) | 2016-10-20 | — | — | US | claimed |
| EP-3625342-A1 | SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING | The Broad Institute, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |
| CN-110257379-A | For treating the oligonucleotides of muscular dystrophy patient | 马林生物科技有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-104603271-B | Oligonucleotides for treating patients with muscular dystrophy | 马林生物科技有限公司 | 2019-07-19 | — | — | CN | disclosed |
| WO-2018213726-A1 | SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING | THE BROAD INSTITUTE, INC. (US) | 2018-11-22 | — | — | WO | disclosed |
| WO-2013123996-A1 | NOVEL SIRNA INHIBITORS OF HUMAN ICAM-1 | ASTRAZENECA UK LIMITED (GB) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160303047-A1 | MEANS FOR LUNG SPECIFIC DELIVERY | SGMS1, SGMS2, DEGS1 | PPARG 1137/4885CHRM1 109/4885TOP1 3004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.